{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:25:16Z","timestamp":1780565116157,"version":"3.54.1"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Although the number of patients who undergo extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation is increasing worldwide, there are few reports on lung transplantation after long-term ECMO (more than 1\u00a0month). We report a rare case of successful bilateral lung transplantation in a Japanese patient after 5\u00a0months of veno-venous (VV)-ECMO support.<\/jats:p>\n <\/jats:sec>\n Case presentation<\/jats:title>\n A 27-year-old man who underwent bone marrow transplantation (BMTx) with fully matched human leukocyte antigen typing was diagnosed with bronchiolitis obliterans caused by chronic graft-versus-host disease 3\u00a0years after the BMTx. One year later, his respiratory condition had exacerbated, with carbon dioxide retention that required conventional mechanical ventilation. He was then deemed a suitable candidate for lung transplantation by a multidisciplinary transplantation selection committee. While waiting for donor lungs, his hypercapnia and acidosis became barely manageable under care with mechanical ventilation and ultimately he was switched to VV-ECMO. He remained on VV-ECMO for the next 5\u00a0months, during which period the circuit was switched nine times. In addition, sophisticated intensive care was required to manage multiple episodes of sepsis and coagulopathy. A suitable donor was identified 5\u00a0months later, and bilateral lung transplantation was initiated with continuous VV-ECMO. The procedure itself was extremely challenging owing to severe adhesions resulting from previous thoracotomy, inflammation, infection, and intrapulmonary hemorrhage. The operative time for the transplantation was about 19\u00a0h. Currently, at 2\u00a0years 8\u00a0months postoperatively, the patient is alive and well.<\/jats:p>\n <\/jats:sec>\n Conclusion<\/jats:title>\n Transplant surgery in this patient was extremely challenging because of the presence of severe pleural adhesions and stiff native lungs secondary to hemorrhagic complications due to the prolonged ECMO support. Surgeons must recognize that lung transplantation after long-term ECMO bridging can be technically more complicated and challenging than shorter-term ECMO.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13019-021-01614-8","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T09:03:56Z","timestamp":1630314236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung transplant after long-term veno-venous extracorporeal membrane oxygenation: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Nobuyuki","family":"Yoshiyasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Anraku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Ichiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"1614_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1097\/MAT.0000000000000731","volume":"64","author":"A Tsiouris","year":"2018","unstructured":"Tsiouris A, Budev MM, Yun JJ. Extracorporeal membrane oxygenation as a bridge to lung transplantation in the United States: a multicenter survey. ASAIO J. 2018;64:689\u201393.","journal-title":"ASAIO J"},{"key":"1614_CR2","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.healun.2019.09.004","volume":"38","author":"EB Rosenzweig","year":"2019","unstructured":"Rosenzweig EB, Gannon WD, Madahar P, Agerstrand C, Abrams D, Liou P, et al. Extracorporeal life support bridge for pulmonary hypertension: a high-volume single-center experience. J Heart Lung Transplant. 2019;38:1275\u201385.","journal-title":"J Heart Lung Transplant"},{"key":"1614_CR3","doi-asserted-by":"publisher","first-page":"S631","DOI":"10.21037\/jtd.2016.06.38","volume":"8","author":"H Date","year":"2016","unstructured":"Date H. Current status and problems of lung transplantation in Japan. J Thorac Dis. 2016;8:S631\u20136.","journal-title":"J Thorac Dis"},{"key":"1614_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13019-020-1046-0","volume":"15","author":"E Skansebo","year":"2020","unstructured":"Skansebo E, Broom\u00e9 M, Magnusson J, Riise GC, Dellgren G. Extended use of extracorporeal membrane oxygenation as bridge to lung transplantation in two patients. J Cardiothorac Surg. 2020;15:16.","journal-title":"J Cardiothorac Surg"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01614-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-021-01614-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01614-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T09:11:00Z","timestamp":1630314660000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-021-01614-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1614"],"URL":"https:\/\/doi.org\/10.1186\/s13019-021-01614-8","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"7 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethics committee at The University of Tokyo Hospital granted approval for publishing this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We obtained consent for publication from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"246"}}