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PAUs occur at any point throughout the aorta, most commonly in the descending thoracic aorta and less frequently in the aortic arch. Open surgical repair and total\/hybrid endovascular repair are currently available to treat aortic arch PAUs. Herein, we present a patient with aortic arch PAU who underwent transthoracic minimally invasive closure, which is a novel method for the treatment of PAU. We describe a 52-year old Asian man who presented with sudden chest and back pain for 8\u00a0h. Computed tomography angiography  showed that the PAU occurred in the aortic arch and had a diameter of 16\u00a0mm and a depth of 6\u00a0mm. The opening was successfully closed via transthoracic minimally invasive closure with an atrial septal defect occluder.<\/jats:p>","DOI":"10.1186\/s13019-021-01659-9","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T18:07:47Z","timestamp":1633889267000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transthoracic minimally invasive closure for the treatment of arch penetrating aortic ulcer: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Shixiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingren","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"issue":"41","key":"1659_CR1","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"R Erbel","year":"2014","unstructured":"Erbel R, Aboyans V, Boileau C, et al. 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