{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:24:56Z","timestamp":1772166296449,"version":"3.50.1"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The indications for surgical resection concerning multiple bilateral neurofibromas in the superior mediastinum remain controversial, because vascular injury or development of postoperative Horne syndrome are concerned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 60-year-old woman presented with multiple nodules in her right neck and bilateral chest cavity tops which indicated neurofibromatosis. The thoracic masses grew slowly over 9\u00a0years, and she then underwent a 2-stage resection starting with the left to right side. Bilateral tumors were completely removed via video-assisted thoracic surgery. The patient\u2019s postoperative course was uneventful, without postoperative Horner syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first case of multiple bilateral superior mediastinal neurofibromas resected from the pulmonary apices via thoracoscopy. We selected a minimally invasive pure video-assisted thoracoscopic surgery approach and enucleated some tumors to avoid nerve injury. This approach may be safe and useful for multiple neurofibromas in patients with neurofibromatosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-021-01690-w","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T07:31:08Z","timestamp":1634715068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thoracoscopic resection of bilateral multiple superior mediastinal neurofibromas"],"prefix":"10.1186","volume":"16","author":[{"given":"Yoko","family":"Azuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naobumi","family":"Tochigi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-4840","authenticated-orcid":false,"given":"Akira","family":"Iyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"1690_CR1","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1378\/chest.112.5.1344","volume":"112","author":"DC Strollo","year":"1997","unstructured":"Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344\u201357.","journal-title":"Chest"},{"key":"1690_CR2","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/S0140-6736(09)60259-2","volume":"373","author":"AR Asthagiri","year":"2009","unstructured":"Asthagiri AR, Parry DM, Butman JA, Kim HJ, Tsilou ET, Zhuang Z, et al. Neurofibromatosis type 2. Lancet. 2009;373:1974\u201386.","journal-title":"Lancet"},{"key":"1690_CR3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/S0003-4975(10)60477-8","volume":"36","author":"HC Grillo","year":"1983","unstructured":"Grillo HC, Ojemann RG, Scannell JG, Zervas NT. Combined approach to \u201cdumbbell\u201d intrathoracic and intraspinal neurogenic tumors. Ann Thorac Surg. 1983;36:402\u20137.","journal-title":"Ann Thorac Surg"},{"key":"1690_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.5761\/atcs.cr.12.01937","volume":"19","author":"R Kanzaki","year":"2013","unstructured":"Kanzaki R, Inoue M, Minami M, Sawabata N, Shintani Y, Nakagiri T, et al. Bilateral mediastinal neurofibroma of the vagus nerves in a patient with neurofibromatosis type 1. Ann Thorac Cardiovasc Surg. 2013;19:293\u20136.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"1690_CR5","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1007\/s005950200215","volume":"32","author":"Y Shintani","year":"2002","unstructured":"Shintani Y, Ohta M, Hazama K, Minami M, Okumura M, Hirabayashi H, et al. Bilateral cervicomediastinal neurofibroma originating from the vagal nerve in a patient with von Recklinghausen\u2019s disease: report of a case. Surg Today. 2002;32:1068\u201371.","journal-title":"Surg Today"},{"key":"1690_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2214\/ajr.112.2.389","volume":"112","author":"A Newman","year":"1971","unstructured":"Newman A, So SK. Bilateral neurofibroma of the intrathoracic vagus associated with Von Recklinghausen\u2019s disease. Am J Roentgenol Radium Ther Nucl Med. 1971;112:389\u201392.","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"1690_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.athoracsur.2005.02.012","volume":"80","author":"S Endo","year":"2005","unstructured":"Endo S, Murayama F, Otani S, Tetsuka K, Hasegawa T, Sato Y, et al. Alternative surgical approaches for apical neurinomas: a thoracoscopic approach. Ann Thorac Surg. 2005;80:295\u20138.","journal-title":"Ann Thorac Surg"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01690-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-021-01690-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01690-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T04:22:40Z","timestamp":1635222160000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-021-01690-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1690"],"URL":"https:\/\/doi.org\/10.1186\/s13019-021-01690-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-76657\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"assertion":[{"value":"11 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of the <i>Journal of Cardiothoracic Surgery<\/i>.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"310"}}