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The prognostic impact of uncorrected FMR prior to left ventricular assist device (LVAD) implantation remains controversial.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between 2016 and 2019 77 patients underwent continuous-flow LVAD implantation at our institution. 34 patients showed FMR\u2009\u2265\u20092 (<jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold>), whereas 43 patients showed FMR\u2009&lt;\u20092 (<jats:bold><jats:italic>Control-group<\/jats:italic><\/jats:bold>). Data was retrospectively analyzed. Primary composite endpoint comprised freedom from death, stroke, pump-thrombosis, major bleeding and right heart failure (RHF) after 1\u00a0year.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Baseline characteristics, including the severity of left and right ventricular dysfunction, and periprocedural results were comparable. The overall survival during a mean follow up of 24.9\u00a0months was 55.9% in the <jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold> versus 58.1% in the <jats:bold><jats:italic>Control-group<\/jats:italic><\/jats:bold> (<jats:italic>p<\/jats:italic>\u2009=\u20090.963), whereas 1-year event-free survival was 35.3% in the <jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold> compared to 44.2% in the <jats:bold><jats:italic>Control-group<\/jats:italic><\/jats:bold> (<jats:italic>p<\/jats:italic>\u2009=\u20090.404). RHF within the first postoperative year occurred more frequently in the <jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold> (35.3% vs. 11.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.017). Furthermore, RV function was significantly reduced in comparison to baseline values in the <jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold>. 12\u00a0months after surgery, 74% of patients in the <jats:bold><jats:italic>MR-group<\/jats:italic><\/jats:bold> were classified as NYHA III in comparison to 24% of patients in the <jats:bold><jats:italic>Control-group<\/jats:italic><\/jats:bold> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Preoperative uncorrected FMR prior to LVAD implantation did not affect overall survival, nevertheless it was associated with an impaired RV function and increased incidence of right heart failure during follow-up. Furthermore, preoperative FMR\u2009\u2265\u20092 was associated with persistent symptoms of heart failure.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-021-01748-9","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T10:03:12Z","timestamp":1645783392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic impact of functional mitral regurgitation prior to left ventricular assist device implantation"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-1815","authenticated-orcid":false,"given":"Jonas","family":"Pausch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Bhadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Mersmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Sill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Barten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"issue":"9","key":"1748_CR1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jchf.2017.06.015","volume":"5","author":"R Nasser","year":"2017","unstructured":"Nasser R, Van Assche L, Vorlat A, Vermeulen T, Van Craenenbroeck E, Conraads V, et al. 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