{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:07:47Z","timestamp":1788599267575,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Complex cardiac surgery and prolonged cardiopulmonary bypass are associated with significant activation of the systemic inflammatory response system. Pro-inflammatory cytokines, oxygen free radicals and complement activation products contribute to postoperative complications and multiorgan injury. CytoSorb\u00ae hemoadsorption therapy has been suggested to alleviate the hyperinflammatory response triggered by cardiopulmonary bypass during cardiac surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We describe the use of CytoSorb\u00ae hemoadsorption therapy in a 61-year-old male presenting for aortic valve replacement, mitral valve replacement, tricuspid valve repair, coronary artery bypass grafting and left atrial appendage clip.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We were able to demonstrate that CytoSorb\u00ae use during cardiopulmonary bypass may be a safe and feasible adjunct therapy that may contribute to improved postoperative outcomes in a patient with complex cardiac disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-022-01922-7","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:02:51Z","timestamp":1657180971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of CytoSorb\u00ae hemoadsorption column during prolonged cardiopulmonary bypass in complex cardiac surgery patient"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-4989","authenticated-orcid":false,"given":"Marianne","family":"Alarie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Savelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danika","family":"Vautour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igo B.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"1922_CR1","doi-asserted-by":"crossref","unstructured":"Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardio-Thoracic Surg. [cited 2021 Dec 7]. Available from: https:\/\/academic.oup.com\/ejcts\/article\/21\/2\/232\/410356?login=true.","DOI":"10.1016\/S1010-7940(01)01099-5"},{"issue":"2","key":"1922_CR2","doi-asserted-by":"publisher","first-page":"S715","DOI":"10.1016\/S0003-4975(02)04701-X","volume":"75","author":"JH Levy","year":"2003","unstructured":"Levy JH, Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg. 2003;75(2):S715\u201320.","journal-title":"Ann Thorac Surg"},{"issue":"1\u20132","key":"1922_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000502540","volume":"49","author":"S Zuccari","year":"2020","unstructured":"Zuccari S, Damiani E, Domizi R, Scorcella C, D\u2019Arezzo M, Carsetti A, et al. Changes in cytokines, haemodynamics and microcirculation in patients with sepsis\/septic shock undergoing continuous renal replacement therapy and blood purification with CytoSorb. 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Available from: https:\/\/cytosorbents.com\/health-canada-authorizes-cytosorb-for-use-in-hospitalized-covid-19-patients\/."},{"issue":"1","key":"1922_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.athoracsur.2018.12.032","volume":"108","author":"K Hassan","year":"2019","unstructured":"Hassan K, Kannmacher J, Wohlmuth P, Budde U, Schmoeckel M, Geidel S. Cytosorb adsorption during emergency cardiac operations in patients at high risk of bleeding. Ann Thorac Surg. 2019;108(1):45\u201351.","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"1922_CR9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1159\/000492379","volume":"46","author":"A Bonavia","year":"2018","unstructured":"Bonavia A, Groff A, Karamchandani K, Singbartl K. Clinical utility of extracorporeal cytokine hemoadsorption therapy: a literature review. Blood Purif. 2018;46(4):337\u201349.","journal-title":"Blood Purif"},{"issue":"1","key":"1922_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13054-019-2399-4","volume":"23","author":"EC Poli","year":"2019","unstructured":"Poli EC, Alberio L, Bauer-Doerries A, Marcucci C, Roumy A, Kirsch M, et al. Cytokine clearance with CytoSorb\u00ae during cardiac surgery: a pilot randomized controlled trial. Crit Care. 2019;23(1):108.","journal-title":"Crit Care"},{"issue":"1","key":"1922_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13054-016-1270-0","volume":"20","author":"MH Bernardi","year":"2016","unstructured":"Bernardi MH, Rinoesl H, Dragosits K, Ristl R, Hoffelner F, Opfermann P, et al. Effect of hemoadsorption during cardiopulmonary bypass surgery\u2014a blinded, randomized, controlled pilot study using a novel adsorbent. 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