{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:03:13Z","timestamp":1765486993705},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Key Research Project of Sichuan Province","award":["2023YFS0199"],"award-info":[{"award-number":["2023YFS0199"]}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Science and Technology Project","doi-asserted-by":"crossref","award":["2022-YF05-01833-SN"],"award-info":[{"award-number":["2022-YF05-01833-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sichuan Cadre Health Care Research Project","award":["GBKT23020"],"award-info":[{"award-number":["GBKT23020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Fibrous mediastinitis (FM) is a rare mediastinal lesion characterized by proliferation of fibrous tissue within the mediastinum. Previous reports have shown that this lesion can be caused by histoplasmosis and tuberculosis. In extremely rare cases, FM can also be caused by autoimmune diseases such as antineutrophil cytoplasmic antibody-associated vasculitis and large-vessel arteritis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In our case, we report unexpected fibrous mediastinitis found after robotic thymectomy in a patient with myasthenia gravis (MG). The preoperative imaging indicated no obvious lesion in the mediastinum and the patient denied histories of both histoplasmosis and tuberculosis. After the operation, both proliferation of fibrous tissue and ectopic germinal centres (GCs) could be found in the thymus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This rare case might enrich our knowledge of the relationship between FM and autoimmune diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-023-02417-9","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:02:36Z","timestamp":1699970556000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unexpected fibrous mediastinitis in a patient with myasthenia gravis - a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Xuyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"issue":"6","key":"2417_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/MD.0b013e318237c8e6","volume":"90","author":"T Peikert","year":"2011","unstructured":"Peikert T, Colby TV, Midthun DE, Pairolero PC, Edell ES, Schroeder DR, Specks U. Fibrosing mediastinitis: clinical presentation, therapeutic outcomes, and adaptive immune response. Med (Baltim). 2011;90(6):412\u201323. https:\/\/doi.org\/10.1097\/MD.0b013e318237c8e6.","journal-title":"Med (Baltim)"},{"issue":"3","key":"2417_CR2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/s12016-016-8584-1","volume":"52","author":"GM Rossi","year":"2017","unstructured":"Rossi GM, Emmi G, Corradi D, Urban ML, Maritati F, Landini F, Galli P, Palmisano A, Vaglio A. Idiopathic Mediastinal Fibrosis: a systemic Immune-mediated disorder. A Case Series and a review of the literature. Clin Rev Allergy Immunol. 2017;52(3):446\u201359. https:\/\/doi.org\/10.1007\/s12016-016-8584-1.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"10","key":"2417_CR3","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S1474-4422(15)00145-3","volume":"14","author":"NE Gilhus","year":"2015","unstructured":"Gilhus NE, Verschuuren JJ. Myasthenia gravis: subgroup classification and therapeutic strategies. Lancet Neurol. 2015;14(10):1023\u201336. https:\/\/doi.org\/10.1016\/S1474-4422(15)00145-3.","journal-title":"Lancet Neurol"},{"issue":"9","key":"2417_CR4","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.autrev.2013.03.007","volume":"12","author":"A Marx","year":"2013","unstructured":"Marx A, Pfister F, Schalke B, Saruhan-Direskeneli G, Melms A, Str\u00f6bel P. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev. 2013;12(9):875\u201384. https:\/\/doi.org\/10.1016\/j.autrev.2013.03.007.","journal-title":"Autoimmun Rev"},{"issue":"1","key":"2417_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1212\/wnl.55.1.16","volume":"55","author":"A Jaretzki III","year":"2000","unstructured":"Jaretzki A III, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, Sanders DB. Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology. 2000;55(1):16\u201323. https:\/\/doi.org\/10.1212\/wnl.55.1.16.","journal-title":"Neurology"},{"issue":"3","key":"2417_CR6","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1016\/j.athoracsur.2021.11.046","volume":"114","author":"H Zhang","year":"2022","unstructured":"Zhang H, Wang F, Qiu G, Li Z, Chen LQ, Wang Y. Surgical Tips to improve completeness of Transsubxiphoid Robotic Extended Thymectomy. Ann Thorac Surg. 2022;114(3):e223\u20135. https:\/\/doi.org\/10.1016\/j.athoracsur.2021.11.046.","journal-title":"Ann Thorac Surg"},{"key":"2417_CR7","doi-asserted-by":"publisher","unstructured":"Ramos-Vara JA. Principles and methods of immunohistochemistry. Drug Saf Evaluation: Methods Protocols 2011:83\u201396. https:\/\/doi.org\/10.1007\/978-1-60761-849-2_5.","DOI":"10.1007\/978-1-60761-849-2_5"},{"issue":"3","key":"2417_CR8","first-page":"257","volume":"12","author":"DB Flieder","year":"1999","unstructured":"Flieder DB, Suster S, Moran CA. Idiopathic fibroinflammatory (fibrosing\/sclerosing) lesions of the mediastinum: a study of 30 cases with emphasis on morphologic heterogeneity. Mod Pathol. 1999;12(3):257\u201364.","journal-title":"Mod Pathol"},{"issue":"4","key":"2417_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/PAP.0000000000000223","volume":"26","author":"KE Lindholm","year":"2019","unstructured":"Lindholm KE, de Groot P, Moran CA. Fibrosing\/Sclerosing lesions of the Mediastinum: a review. Adv Anat Pathol. 2019;26(4):235\u201340. https:\/\/doi.org\/10.1097\/PAP.0000000000000223.","journal-title":"Adv Anat Pathol"},{"issue":"3","key":"2417_CR10","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1148\/radiographics.21.3.g01ma17737","volume":"21","author":"SE Rossi","year":"2001","unstructured":"Rossi SE, McAdams HP, Rosado-de-Christenson ML, Franks TJ, Galvin JR. Fibrosing mediastinitis. Radiographics. 2001;21(3):737\u201357. https:\/\/doi.org\/10.1148\/radiographics.21.3.g01ma17737.","journal-title":"Radiographics"},{"issue":"9","key":"2417_CR11","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1164\/rccm.201407-1258LE","volume":"190","author":"BD Westerly","year":"2014","unstructured":"Westerly BD, Johnson GB, Maldonado F, Utz JP, Specks U, Peikert T. Targeting B lymphocytes in Progressive fibrosing mediastinitis. 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Written informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Informed written consent was obtained from the patient for publication of this report and any accompanying images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"322"}}