{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:40:38Z","timestamp":1793479238126,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory myofibroblastic tumor (IMT), also known as an inflammatory pseudotumor, is a unique type of intermediate soft tissue tumor that commonly occurred in the lung. Its unclear etiology and cellular activity brought about the confusion not only in naming of it, but also in diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We reported the case of an 18-year-old male student who suffered from shortness of breath, chest tightness and chest pain. Chest computed tomography scan showed a spherical neoplasm blocking left main stem bronchus. After fiberoptic bronchoscopy procedure, the results of histopathological and immunohistochemical analysis indicated an IMT. The targeted next generation sequencing based genomic profiling of the tumor using formalin-fixed and paraffin embedded tissue was performed and a\n                      <jats:italic>EML4-ALK<\/jats:italic>\n                      fusion was detected. The patient began to receive Crizotinib, a\n                      <jats:italic>ALK<\/jats:italic>\n                      tyrosine kinase inhibitor, at a dose of 250\u00a0mg twice daily orally. The patient has recovered well after the operation, and no recurrence or metastasis has been found after 12 months\u2019 follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By means of the diagnosis and treatment of this case, the characteristics and therapies of IMT are illustrated. In addition, it also provides a reference for the therapeutic strategy of IMT in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-023-02427-7","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T12:02:24Z","timestamp":1699617744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Crizotinib combined with bronchoscopic interventional treatment in ALK-positive inflammatory myofibroblastic tumor of left main stem bronchus: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"2427_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12032-018-1161-0","volume":"35","author":"AES Sagar","year":"2018","unstructured":"Sagar AES, Jimenez CA, Shannon VR. Clinical and histopathologic correlates and management strategies for inflammatory myofibroblastic Tumor of the lung. A case series and review of the literature. Med Oncol. 2018;35:102. https:\/\/doi.org\/10.1007\/s12032-018-1161-0.","journal-title":"Med Oncol"},{"key":"2427_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4103\/0973-1482.163872","volume":"11","author":"C Zhang","year":"2015","unstructured":"Zhang C, Li CJ, Zong WK, Xu ML, Fan GW. One case of inflammatory myofibroblastic Tumor - a case report. J Can Res Ther. 2015;11:131\u20133. https:\/\/doi.org\/10.4103\/0973-1482.163872.","journal-title":"J Can Res Ther"},{"key":"2427_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12032-018-1161-0","volume":"35","author":"AES Sagar","year":"2018","unstructured":"Sagar AES, Jimenez CA, Shannon VR. Clinical and histopathologic correlates and management strategies for inflammatory myofibroblastic Tumor of the lung. 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