{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:53:49Z","timestamp":1792313629562,"version":"4.4.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Thymic carcinomas are rare and aggressive tumours. They constitute a heterogeneous group of tumours with various histological patterns and subtypes resembling epithelial tumours arising from other organs.<\/jats:p>\n                <jats:p>Case presentation.<\/jats:p>\n                <jats:p>We hereby represent a case of primary thymic carcinoma with adenoid cystic carcinoma-like features (TCACC) which is an extremely rare variant of thymic adenocarcinoma. To date and to the best of our knowledge, there are nine reported cases in literature and ours is the tenth. Our case was treated surgically but the implementation of adjuvant chemoradiotherapy has been reported in few of the published cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TCACC constitutes a rare entity of thymic adenocarcinoma with limited available literature. The current data is derived from few case reports and case series. The histological overlap of these tumours and primary ACC of salivary glands poses a diagnostic challenge. Radiological investigations, immunohistochemical phenotyping and genetic analysis are crucial in establishing the diagnosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-023-02432-w","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:27:40Z","timestamp":1699518460000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adenoid cystic carcinoma of the thymus gland"],"prefix":"10.1186","volume":"18","author":[{"given":"Mohamed","family":"Shatila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Hemead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Murukesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Taniere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvini","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"2432_CR1","unstructured":"Board WW. classification of tumours. Thoracic Tumours (M): Lyon: IARC Press; 2021."},{"issue":"8","key":"2432_CR2","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1097\/PAS.0b013e3180555ba8","volume":"31","author":"L Di Tommaso","year":"2007","unstructured":"Di Tommaso L, Kuhn E, Kurrer M, et al. Thymic tumor with adenoid cystic carcinoma like features: a clinicopathologic study of 4 cases. Am J Surg Pathol. 2007;31(8):1161\u20137.","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"2432_CR3","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","volume":"51","author":"A Coca-Pelaz","year":"2015","unstructured":"Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck\u2013An update. Oral Oncol. 2015;51(7):652\u201361.","journal-title":"Oral Oncol"},{"issue":"1","key":"2432_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/PAS.0b013e3182002777","volume":"35","author":"RB West","year":"2011","unstructured":"West RB, Kong C, Clarke N, et al. MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol. 2011;35(1):92.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2432_CR5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.5761\/atcs.cr.11.01836","volume":"18","author":"R Kanzaki","year":"2012","unstructured":"Kanzaki R, Ikeda N, Okura E, et al. Thymic carcinoma with adenoid cystic carcinomalike features with distant metastases. Ann Thorac Cardiovasc Surg. 2012;18(6):544\u20137.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2432_CR6","unstructured":"Coulibaly B, Marcy M, Fernandez C, Thomas P, Giudicelli R, Tas\u00e9i A-M. Primary thymic adenoid cystic carcinoma mimicking a teratoma: a case report. 2008."},{"issue":"4","key":"2432_CR7","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1016\/j.athoracsur.2010.07.044","volume":"90","author":"F Banki","year":"2010","unstructured":"Banki F, Khalil K, Kott MM, Cota AL. Adenoid Cystic Carcinoma of the thymus gland: a rare tumor. Ann Thorac Surg. 2010;90(4):e56\u20138.","journal-title":"Ann Thorac Surg"},{"issue":"31","key":"2432_CR8","doi-asserted-by":"publisher","first-page":"e21531","DOI":"10.1097\/MD.0000000000021531","volume":"99","author":"M-Q Yang","year":"2020","unstructured":"Yang M-Q, Bai L-L, Wang Z, Huang W-J, Jiang G-Y, Xu H-T. Primary thymic carcinoma with adenoid cystic carcinoma-like features. Medicine. 2020;99(31):e21531.","journal-title":"Medicine"},{"issue":"7","key":"2432_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1177\/1066896915585348","volume":"23","author":"D Rampisela","year":"2015","unstructured":"Rampisela D, Zreik R, Donner LR. Thymic tumor with adenoid cystic carcinoma-like features: a study of a clinically favorable case followed for 9 years. Int J Surg Pathol. 2015;23(7):557\u201360.","journal-title":"Int J Surg Pathol"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-023-02432-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-023-02432-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-023-02432-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T18:04:05Z","timestamp":1699553045000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-023-02432-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2432"],"URL":"https:\/\/doi.org\/10.1186\/s13019-023-02432-w","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"10 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There was no ethical approval needed as this did not directly involve patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent was sought from the patient in question.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}