{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:43:10Z","timestamp":1786617790956,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The management for pneumothorax patients involves surgical intervention, nevertheless postoperative recurrences are often encountered. To reduce the rates of recurrence, thoracic surgeons have experimented with various novel techniques, such as pleural abrasion, chemical pleurodesis, and staple line coverage with absorbable sheets, in addition to bullectomy. And in recent years, there have been reports of the effectiveness of the use of intraoperative glucose intrapleural spray (GIS) containing 50\u00a0ml of 50% glucose solution in addition to bullectomy. However, information on the effects and adverse events of GIS is limited. Current study was aimed to assess the efficacy and safety of GIS in preventing recurrence of pneumothorax.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients and methods<\/jats:title>\n                <jats:p>We conducted a retrospective study with 74 cases of bullectomy with or without GIS between 2018 and 2021 at Okazaki City Hospital. Of these cases, 50 received GIS (GIS group) while 24 were treated conservatively (C group).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>The GIS group consisted of 46 males and 4 females, whereas the C group consisted of 23 males and 1 female, with mean ages of 38.5\u2009\u00b1\u20095.7\u00a0years and 30.5\u2009\u00b1\u20096.7\u00a0years, respectively. The GIS group exhibited a mean increase in blood glucose of 23.8\u00a0mg\/dL postoperatively, and postoperative infections were observed in 2 cases in the GIS group (4.0%) and 2 cases in the C group (8.3%). The NRS scores of the patients in the GIS group and the C group three hours postoperatively were 4.0 and 3.1, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.28). No prolongation of postoperative drainage period by GIS was observed (1.2\u00a0days and 1.4\u00a0days in the GIS and C groups, respectively). Postoperative recurrence occurred in two patients from the C group. The postoperative total drainage volumes were 341.8\u2009\u00b1\u200925.2\u00a0ml and 74.2\u2009\u00b1\u200925.5\u00a0ml in the GIS and C groups, respectively, showing a significant increase in drainage volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). None of them presented dehydration-related symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The use of intraoperative glucose intrapleural spray is effective and safe in terms of preventing recurrences and postoperative complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02486-4","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T09:02:18Z","timestamp":1705741338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of intraoperative partial spray of 50% glucose for patients with spontaneous pneumothorax"],"prefix":"10.1186","volume":"19","author":[{"given":"Ryota","family":"Kiriyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Oyamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seijiro","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Okagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyofumi Fengshi","family":"Chen-Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"issue":"Suppl 2","key":"2486_CR1","doi-asserted-by":"publisher","first-page":"ii18","DOI":"10.1136\/thx.2010.136986","volume":"65","author":"A MacDuff","year":"2010","unstructured":"MacDuff A, Arnold A, Harvey J, BTS Pleural Disease Guideline Group. Management of spontaneous pneumothorax: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010;65(Suppl 2):ii18\u201331.","journal-title":"Thorax."},{"key":"2486_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1183\/09031936.00219214","volume":"46","author":"JM Tschopp","year":"2015","unstructured":"Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, et al. ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax. Eur Respir J. 2015;46:321\u201335.","journal-title":"Eur Respir J"},{"key":"2486_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1183\/09059180.00005310","volume":"19","author":"M Noppen","year":"2010","unstructured":"Noppen M. Spontaneous pneumothorax: epidemiology, pathophysiology and cause. Eur Respir Rev. 2010;19:217\u20139.","journal-title":"Eur Respir Rev"},{"key":"2486_CR4","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1378\/chest.119.2.590","volume":"119","author":"MH Baumann","year":"2001","unstructured":"Baumann MH, Strange C, Heffner JE, Light R, Kirby TJ, Klein J, et al. Management of spontaneous pneumothorax: an American College of Chest Physicians Delphi consensus statement. Chest. 2001;119:590\u2013602.","journal-title":"Chest"},{"key":"2486_CR5","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/B0-12-370879-6\/00318-5","volume-title":"Encyclopedia of respiratory medicine","author":"C Strange","year":"2006","unstructured":"Strange C, Huggins JT. PNEUMOTHORAX. In: Laurent GJ, Shapiro SD, editors. Encyclopedia of respiratory medicine. Oxford: Academic Press; 2006. p. 474\u20139."},{"key":"2486_CR6","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1016\/j.athoracsur.2014.06.047","volume":"98","author":"S Lee","year":"2014","unstructured":"Lee S, Kim HR, Cho S, Huh DM, Lee EB, Ryu KM, et al. Staple line coverage after bullectomy for primary spontaneous pneumothorax: a randomized trial. Ann Thorac Surg. 2014;98:2005\u201311.","journal-title":"Ann Thorac Surg"},{"key":"2486_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.athoracsur.2018.02.040","volume":"106","author":"K Tsuboshima","year":"2018","unstructured":"Tsuboshima K, Wakahara T, Matoba Y, Maniwa Y. Pleural coating by 50% glucose solution reduces postoperative recurrence of spontaneous pneumothorax. Ann Thorac Surg. 2018;106:184\u201391.","journal-title":"Ann Thorac Surg"},{"key":"2486_CR8","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s004649900805","volume":"12","author":"H Horio","year":"1998","unstructured":"Horio H, Nomori H, Fuyuno G, Kobayashi R, Suemasu K. Limited axillary thoracotomy vs video-assisted thoracoscopic surgery for spontaneous pneumothorax. Surg Endosc. 1998;12:1155\u20138.","journal-title":"Surg Endosc"},{"key":"2486_CR9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.5761\/atcs.oa.12.01986","volume":"19","author":"T Tsukioka","year":"2013","unstructured":"Tsukioka T, Inoue K, Oka H, Mizuguchi S, Morita R, Nishiyama N. Pleurodesis with a 50% glucose solution in patients with spontaneous pneumothorax in whom an operation is contraindicated. Ann Thorac Cardiovasc Surg. 2013;19:358\u201363.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2486_CR10","doi-asserted-by":"publisher","first-page":"398","DOI":"10.4172\/2161-105X.1000398","volume":"7","author":"S Kajikawa","year":"2017","unstructured":"Kajikawa S. Experience of pleurodesis with a 50% glucose solution in patients with secondary pneumothorax: a case series. J Pulm Respir Med. 2017;7:398.","journal-title":"J Pulm Respir Med"},{"key":"2486_CR11","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00595-015-1223-2","volume":"46","author":"K Fujino","year":"2016","unstructured":"Fujino K, Motooka Y, Koga T, Osumi H, Matsubara E, Shibata H, et al. Novel approach to pleurodesis with 50 % glucose for air leakage after lung resection or pneumothorax. Surg Today. 2016;46:599\u2013602.","journal-title":"Surg Today"},{"key":"2486_CR12","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s00595-015-1236-x","volume":"46","author":"H Katayama","year":"2016","unstructured":"Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N, et al. Extended Clavien\u2013Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today. 2016;46:668\u201385.","journal-title":"Surg Today"},{"key":"2486_CR13","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.jpainsymman.2010.08.016","volume":"41","author":"MJ Hjermstad","year":"2011","unstructured":"Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manag. 2011;41:1073\u201393.","journal-title":"J Pain Symptom Manag"},{"key":"2486_CR14","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s00464-003-8918-y","volume":"18","author":"K Sakamoto","year":"2004","unstructured":"Sakamoto K, Takei H, Nishii T, Maehara T, Omori T, Tajiri M, et al. Staple line coverage with absorbable mesh after thoracoscopic bullectomy for spontaneous pneumothorax. Surg Endosc. 2004;18:478\u201381.","journal-title":"Surg Endosc"},{"key":"2486_CR15","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/BF03218248","volume":"48","author":"K Ohno","year":"2000","unstructured":"Ohno K, Miyoshi S, Minami M, Akashi A, Maeda H, Nakagawa K, et al. Ipsilateral recurrence frequency after video-assisted thoracoscopic surgery for primary spontaneous pneumothorax. Jpn J Thorac Cardiovasc Surg. 2000;48:757\u201360.","journal-title":"Jpn J Thorac Cardiovasc Surg"},{"key":"2486_CR16","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.jtcvs.2005.10.025","volume":"131","author":"G Cardillo","year":"2006","unstructured":"Cardillo G, Carleo F, Giunti R, Carbone L, Mariotta S, Salvadori L, et al. Videothoracoscopic talc poudrage in primary spontaneous pneumothorax: a single-institution experience in 861 cases. J Thorac Cardiovasc Surg. 2006;131:322\u20138.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2486_CR17","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.arbres.2016.08.018","volume":"53","author":"S Hamada","year":"2017","unstructured":"Hamada S, Okamoto N, Watanabe I, Tsukino M. Is pleurodesis with 50% glucose solution in patients with spontaneous pneumothorax safe? A case series. Arch Bronconeumol. 2017;53:210\u20131.","journal-title":"Arch Bronconeumol"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02486-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-02486-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02486-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T09:04:01Z","timestamp":1705741441000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-02486-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,20]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2486"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-02486-4","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,20]]},"assertion":[{"value":"11 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of Okazaki City Hospital in Japan (No. 2021-43).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}