{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:38:46Z","timestamp":1788518326151,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Pulmonary primitive neuroectodermal tumor (PNET), a member of the Ewing sarcoma family of tumors, is a rare malignancy that is associated with a grim prognosis. To date, fewer than 30 cases of pulmonary PNET have been reported. In this case report, we present the clinical details of a 12-year-old girl with pulmonary PNET who underwent surgical treatment. We also conducted an analysis and summary of other relevant studies and the surgical outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In May 2018, a 12-year-old girl was admitted with symptoms of cough and blood-tinged phlegm. A computed tomography scan revealed a large mass, measuring 12.9\u00a0cm \u00d7 8.1\u00a0cm, in the right middle and lower lungs. A percutaneous lung biopsy confirmed poorly differentiated tumor cells with a nested growth pattern. Immunohistochemical staining demonstrated positive expression of CD99, CD56, Vimentin, and Synaptophysin. The patient was diagnosed with pulmonary PNET. Following three cycles of neoadjuvant chemotherapy, a substantial reduction in tumor volume was observed. Subsequently, the patient underwent a surgical procedure involving pneumonectomy and partial resection of the left atrium with the assistance of cardiopulmonary bypass. The patient was discharged 37 days after surgery. During a three-year follow-up period, she exhibited no signs of tumor recurrence and has successfully returned to school.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case highlights the successful management of an advanced PNET with neoadjuvant chemotherapy, pneumonectomy, and partial resection of the left atrium employing cardiopulmonary bypass. The patient remained disease-free after three years. Our analysis of surgically treated cases indicates that neoadjuvant chemotherapy can contribute to improved prognoses for PNET patients. It is crucial to emphasize that complete surgical excision remains the cornerstone of treatment, underscoring the importance of surgeons considering radical surgical approaches whenever feasible for patients with pulmonary PNETs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02563-8","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T07:01:58Z","timestamp":1709622118000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review"],"prefix":"10.1186","volume":"19","author":[{"given":"Yiyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2563_CR1","unstructured":"Durer S, Shaikh H. Ewing Sarcoma. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2021. StatPearls Publishing LLC.; 2021."},{"key":"2563_CR2","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1002\/1097-0142(19910401)67:7<1825::AID-CNCR2820670702>3.0.CO;2-3","volume":"67","author":"BH Kushner","year":"1991","unstructured":"Kushner BH, Hajdu SI, Gulati SC, Erlandson RA, Exelby PR, Lieberman PH. Extracranial primitive neuroectodermal tumors. The Memorial Sloan-Kettering Cancer Center experience. Cancer. 1991;67:1825\u20139.","journal-title":"Cancer"},{"key":"2563_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2147\/OTT.S283967","volume":"14","author":"N Wang","year":"2021","unstructured":"Wang N, Dong SS, Wu CL, Wang Y, Meng L, Ren Y, et al. Rare primary pulmonary primitive neuroectodermal tumor: a Case Report and Literature Review. Onco Targets Ther. 2021;14:139\u201344.","journal-title":"Onco Targets Ther"},{"key":"2563_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1746-1596-8-51","volume":"8","author":"L Shi","year":"2013","unstructured":"Shi L, Guo Z, Wu X. Primary pulmonary primitive neuroectodermal tumor metastasis to the pancreas: a rare case with seven-year follow-up. Diagn Pathol. 2013;8:51.","journal-title":"Diagn Pathol"},{"key":"2563_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00408-012-9405-9","volume":"190","author":"A Weissferdt","year":"2012","unstructured":"Weissferdt A, Moran CA. Primary pulmonary primitive neuroectodermal tumor (PNET): a clinicopathological and immunohistochemical study of six cases. Lung. 2012;190:677\u201383.","journal-title":"Lung"},{"key":"2563_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1046\/j.1365-2559.1998.00485.x","volume":"33","author":"S Tsuji","year":"1998","unstructured":"Tsuji S, Hisaoka M, Morimitsu Y, Hashimoto H, Jimi A, Watanabe J, et al. Peripheral primitive neuroectodermal tumour of the lung: report of two cases. Histopathology. 1998;33:369\u201374.","journal-title":"Histopathology"},{"key":"2563_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/1097-0142(19880115)61:2<349::AID-CNCR2820610226>3.0.CO;2-0","volume":"61","author":"H J\u00fcrgens","year":"1988","unstructured":"J\u00fcrgens H, Bier V, Harms D, Beck J, Brandeis W, Etsp\u00fcler G, et al. Malignant peripheral neuroectodermal tumors. A retrospective analysis of 42 patients. 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A case report. Pathol Res Pract. 2001;197:113\u20139. discussion 21\u2009\u2013\u20092.","journal-title":"Pathol Res Pract"},{"issue":"Suppl","key":"2563_CR17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3346\/jkms.2007.22.S.S159","volume":"22","author":"YY Lee","year":"2007","unstructured":"Lee YY, Kim DH, Lee JH, Choi JS, In KH, Oh YW, et al. Primary pulmonary Ewing\u2019s sarcoma\/primitive neuroectodermal tumor in a 67-year-old man. J Korean Med Sci. 2007;22(Suppl):159\u201363.","journal-title":"J Korean Med Sci"},{"key":"2563_CR18","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/00015458.2009.11680443","volume":"109","author":"G Verfaillie","year":"2009","unstructured":"Verfaillie G, Hoorens A, Lamote J. Primary primitive neuro-ectodermal tumour of the lung. 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All methods were carried out in accordance with relevant guidelines and regulations. Written informed consent was obtained from the patient\u2019s parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s parents for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"109"}}