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This study's objective was to determine which inflammatory biomarkers could be used to make a better formula for identifying postoperative hyper-inflammation, and which risk factors were associated with hyper-inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 405 patients were enrolled in this study from October 1, 2020 to April 1, 2023. Of these patients, 124 exhibited poor outcomes. In order to investigate the optimal cut-off values for poor outcomes, logistic and receiver operating characteristic analyses were performed on the following parameters on the first postoperative day: procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), and systemic immune-inflammation index (SII). These cut-off points were used to separate the patients into hyper-inflammatory (n\u2009=\u200952) and control (n\u2009=\u2009353) groups. Finally, the logistic were used to find the risk factors of hyper-inflammatory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCT, CRP, IL-6, and SII were independent risk factors of poor outcomes in the multivariate logistic model. Cut-off points of these biomarkers were 2.18\u00a0ng\/ml, 49.76\u00a0mg\/L, 301.88\u00a0pg\/ml, 2509.96\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L respectively. These points were used to define postoperative hyper-inflammation (OR 2.97, 95% CI 1.35\u20136.53,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Cardiopulmonary bypass (CPB)\u2009&gt;\u2009180\u00a0min, and deep hypothermia circulatory arrest (DHCA)\u2009&gt;\u200940\u00a0min were the independent risk factors for hyper-inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PCT\u2009&gt;\u20092.18, CRP\u2009&gt;\u200949.76, IL-6\u2009&gt;\u2009301.88, and SII\u2009&lt;\u20092509.96 could be used to define postoperative hyper-inflammation which increased mortality and morbidity in patients after ATAAD surgery. Based on these findings, we found that CPB\u2009&gt;\u2009180\u00a0min and DHCA\u2009&gt;\u200940\u00a0min were separate risk factors for postoperative hyper-inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-024-02637-7","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:51:21Z","timestamp":1710816681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postoperative hyper-inflammation as a predictor of poor outcomes in patients with acute type A aortic dissection (ATAAD) undergoing surgical repair"],"prefix":"10.1186","volume":"19","author":[{"given":"Yuan-Xi","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusanjan","family":"Matniyaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Xing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Dong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"17","key":"2637_CR1","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","volume":"137","author":"A Evangelista","year":"2018","unstructured":"Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, et al. 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The study adhered to the ethical principles stated in the \u201cDeclaration of Helsinki\u201d, the International Conference on Harmonisation-Good Clinical Practice (ICH-GCP) guideline, as well as the \u201cQuality Management Standards for Drug Clinical Trials\u201d and \u201cMedical Devices Clinical Trial Quality Management Standards\u201d established by the Chinese Food and Drug Administration (CFDA). Additionally, it complied with the \u201cEthical Review Measures for Biomedical Research Involving Humans\u201d issued by the National Health Commission of China, along with other pertinent national laws and regulations. Prior to their inclusion in the study, the study participant or a legally authorized representative provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"138"}}