{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:08:01Z","timestamp":1790698081089,"version":"4.1.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Aortic pathologies often present with elevated inflammatory biomarkers due to the nature of the disease. Open aortic surgery causes significant trauma to the body due to often mandatory ischemic periods, long cardiopulmonary bypass times and polytransfusion. We aim to determine postoperative trends on inflammation biomarkers for different aortic pathologies and type of surgery in different segments of the aorta.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective review of prospectively collected data of 193 consecutive patients who underwent aortic surgery in our centre between 2017 and 2021, grouped according to the type of aortic intervention: (1) Type A aortic dissection (AD) repair with ascending aorta\/hemiarch replacement, (2) Aortic root replacement (ARR), (3) Aortic arch\u2009+\u2009Frozen elephant trunk (FET), (4) Descending thoracic aorta (DTA)\/Thoraco-Abdominal aortic repair (TAA). Primary outcomes were daily values of white blood cells (WBC) and C-Reactive Protein (CRP) during the first 15 postoperative days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All groups had a similar inflammatory peak in the first 2\u20134 days (WBC 12-15\u2009\u00d7\u2009109 c\/L). AD and FET groups show similar trends with WBC and CRP peaks on days 2 and 10. The ARR group didn\u2019t experience the 2nd peak as most patients were already discharged. DTA\/TAA patients experienced a more prolonged inflammatory response, reaching a plateau by day 5\u201310. AD group shows the highest WBC levels and the DTA\/TAAA group the highest CRP levels. CRP levels remain elevated (100\u2013200\u00a0mg\/L) in all groups after 15 postoperative days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Inflammatory biomarkers show different postoperative trends depending on the clinical presentation and complexity of the aortic procedure performed. Further understanding of the inflammatory response to different aortic pathologies and surgical procedures will permit reduction on the liberal use of antibiotics that this cohort of patients are usually exposed to. An earlier version of the data included in this manuscript was presented as Oral Abstract in the UK Society of Cardiothoracic Surgery Annual meeting in 2021<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02672-4","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:01:51Z","timestamp":1713348111000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammation in aortic surgery: postoperative evolution of biomarkers according pathologies and segments of the aorta"],"prefix":"10.1186","volume":"19","author":[{"given":"Martin T","family":"Yates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina A","family":"Mistirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola M","family":"Bigogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lopez-Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"issue":"2","key":"2672_CR1","first-page":"21","volume":"12","author":"GE Hill","year":"1998","unstructured":"Hill GE. Cardiopulmonary bypass \u2013 induced inflammation: is it important? J Cardiothorac Vasc Anesth. 1998;12(2):21\u20135.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"4","key":"2672_CR2","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/jocs.16300","volume":"37","author":"Y XuH, Li","year":"2022","unstructured":"XuH, Li Y, Wang H, Yuan Y, Chen D, Sun Y, Xu Z. Systemic immune-inflammation index predicted short-term outcomes in ATAD patients undergoing surgery. J Card Surg. 2022;37(4):969\u201375.","journal-title":"J Card Surg"},{"issue":"3","key":"2672_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10753-022-01626-z","volume":"45","author":"G Skotsimara","year":"2022","unstructured":"Skotsimara G, Antonopoulos A, Oikonomou E, Papastamos C, Siasos G, Tousoulis D. Aortic wall inflammation in the pathogenesis, diagnosis and treatment of aortic aneurysms. Inflammation. 2022;45(3):965\u201376.","journal-title":"Inflammation"},{"issue":"6","key":"2672_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2174\/1871528114666150529120801","volume":"13","author":"V Corral-Velez","year":"2015","unstructured":"Corral-Velez V, Lopez-Delgado JC, Betancur-Zambrano N, Lopez-Sune N, Rojas-Lora M, Torrado H, Ballus J. The inflammatory response in cardiac surgery: an overview of the pathophysiology and clinical implications. Inflamm Allergy Drug Targets. 2015;13(6):367\u201370.","journal-title":"Inflamm Allergy Drug Targets"},{"key":"2672_CR5","doi-asserted-by":"crossref","unstructured":"Muylle L, Wouters E, Peetermans ME. Febrle reactions to platelet transfusion: the effect of increased interleukin 6 levels in concentrates prepeareed by the platelet rich plasma method. 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Heart Lung Circ. 2022;31(1):49\u201358.","journal-title":"Heart Lung Circ"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02672-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-02672-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02672-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:03:35Z","timestamp":1713348215000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-02672-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2672"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-02672-4","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"assertion":[{"value":"3 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by our instutional ethical committee. Individual patient consent was waived due to the anonymised nature of the data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have no conflicts of interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}}],"article-number":"239"}}