{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:25:37Z","timestamp":1772166337714,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a rare, self-limiting disease that predominantly affects children and young adults. Moreover, the disease is characterized by painless bilateral cervical lymphadenopathy in 95% of the patients. However, few reports are available on the Rosai-Dorfman disease of the thymus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a rare case of thymic Rosai-Dorfman disease detected using computed tomography. During a medical examination, a 50-year-old man underwent a chest computed tomography scan, which revealed an anterior mediastinal single mass with fat in the thymus. A thymectomy was performed to completely remove the tumor using a thoracoscopic technique due to a clinical suspicion of thymoma. Furthermore, Rosai-Dorfman disease was confirmed using histological and immunohistochemical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the sixth case of thymus-affecting solitary Rosai-Dorfman disease with histological and immunohistochemical evidence. Fat in the thymus, as was present in this case, has never been described in Rosai-Dorfman disease previously. Our results highlight the challenge of diagnosing this uncommon tumor before surgery, and more cases need to be reported to help with the preoperative diagnosis of such a rare tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-024-02714-x","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:02:13Z","timestamp":1712224933000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rosai-Dorfman disease manifesting as a solitary mass with fat in the thymus a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0515-7810","authenticated-orcid":false,"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"2714_CR1","unstructured":"Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol.1969; 87(1):63\u201370."},{"key":"2714_CR2","doi-asserted-by":"crossref","unstructured":"Cangelosi JJ, Prieto VG, Ivan D. Cutaneous Rosai\u2013Dorfman disease with increased number of eosinophils: coincidence or histologic variant? Arch Pathol Lab Med. 2011;135(12):1597\u2013600.","DOI":"10.5858\/arpa.2010-0554-CR"},{"key":"2714_CR3","doi-asserted-by":"crossref","unstructured":"Bi Y, Huo Z, Meng Y, et al. Extranodal Rosai-Dorfman disease involving the right atrium in a 60-year-old male.Diagnostic Pathology.2014;9(1):115.","DOI":"10.1186\/1746-1596-9-115"},{"key":"2714_CR4","doi-asserted-by":"crossref","unstructured":"Gaitonde S. Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy: an overview. Archives of Pathology& Laboratory Medicine. 2007;131(7): 1117\u201321.","DOI":"10.5858\/2007-131-1117-MESHWM"},{"key":"2714_CR5","doi-asserted-by":"crossref","unstructured":"Zhao Q, Bai Y, Dong A, et al. FDG PET\/CT in Isolated Thoracic Vertebral Rosai-Dorfman Disease. Clin. Nucl. Med. 2022; 47(2):e135\u2013e136.","DOI":"10.1097\/RLU.0000000000003911"},{"key":"2714_CR6","doi-asserted-by":"crossref","unstructured":"Mantilla JG, Goldberg-Stein S, Wang Y. Extranodal Rosai-Dorfman disease: clinicopathologic series of 10 patients with radiologic correlation and review of the literature. American Journal of Clinical Pathology. 2016;145(2):211\u2009\u2212\u200921.","DOI":"10.1093\/ajcp\/aqv029"},{"key":"2714_CR7","doi-asserted-by":"crossref","unstructured":"Ahuja J, Kanne JP, Meyer CA, et al. Histiocytic disorders of the chest: imaging findings. Radiographics.2015;35(2):357\u2009\u2212\u200970.","DOI":"10.1148\/rg.352140197"},{"key":"2714_CR8","doi-asserted-by":"crossref","unstructured":"Brito J, Sousa V, Teixeira L, et al. Rosai-Dorfman disease manifesting as a mediastinal mass with calcifications. J Thorac Imaging. 2010; 25(2):30\u2009\u2212\u20092.","DOI":"10.1097\/RTI.0b013e3181a6d0bb"},{"key":"2714_CR9","doi-asserted-by":"crossref","unstructured":"Juskevicius R, Finley JL. Rosai-Dorfman disease of the parotid gland: cytologic and histopathologic findings with immunohistochemical correlation. Archives of Pathology &Laboratory Medicine.2001;125(10):1348\u201350.","DOI":"10.5858\/2001-125-1348-RDDOTP"},{"key":"2714_CR10","doi-asserted-by":"crossref","unstructured":"Amiji I, Mohammed U, Salum H, et al. Rosai\u2013Dorfman disease\u2014a rare case of cervical lymphadenopathy. Clin Case Rep. 2020;8(12):2712\u20135.","DOI":"10.1002\/ccr3.3255"},{"key":"2714_CR11","unstructured":"Wang E, Anzai Y, Paulino A, et al. Rosai-Dorfman disease presenting with isolated bilateral orbital masses: report of two cases. AJNR Am J Neuroradiol. 2001;22(7):1386\u201388."},{"key":"2714_CR12","doi-asserted-by":"crossref","unstructured":"Shen C, Liao H. An extremely rare case of Rosai-Dorfman disease in the thymus. J Cardiothorac Surg. 2021;16(1):212.","DOI":"10.1186\/s13019-021-01595-8"},{"key":"2714_CR13","doi-asserted-by":"crossref","unstructured":"Oramas DM, Moran CA. Primary Rosai-Dorfman disease of the thymus and lung: a clinicopathological and immunohistochemical study of three cases. Pathol Res Pract. 2022;234: 153917.","DOI":"10.1016\/j.prp.2022.153917"},{"key":"2714_CR14","doi-asserted-by":"crossref","unstructured":"Pulsoni A, Anghel G, Falcucci P, et al. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol.2002;69(1):67\u201371.","DOI":"10.1002\/ajh.10008"},{"key":"2714_CR15","doi-asserted-by":"crossref","unstructured":"Karunanithi S, Singh H, Sharma P, et al. 18F-FDG PET\/CT imaging features of Rosai Dorfman disease: A rare cause of massive generalized lymphadenopathy. Clin Nucl Med. 2014; 39(3)268\u20139.","DOI":"10.1097\/RLU.0b013e31828731da"},{"key":"2714_CR16","doi-asserted-by":"crossref","unstructured":"Abla O, Jacobsen E, Picarsic J, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. 2018;131(26):2877\u201390.","DOI":"10.1182\/blood-2018-03-839753"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02714-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-02714-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02714-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:02:57Z","timestamp":1712224977000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-02714-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2714"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-02714-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3574837\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"7 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study involving human participants was reviewed and approved by the Ethics Committee of Sichuan Provincial People\u2019s Hospital. The patient provided his written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors contributed to the article and approved the submitted version.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}