{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:01:11Z","timestamp":1782475271736,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300385"],"award-info":[{"award-number":["82300385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ22H020005"],"award-info":[{"award-number":["LQ22H020005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly which can be congenital or acquired. Patients with SVA are commonly asymptomatic when the occupying effect of SVA is insignificant, while ruptured SVA usually causes severe symptoms including heart failure and myocardial ischemia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present an unusual case of a 64-year-old female manifesting with exertional dyspnea as well as angina pectoris for three months. Echocardiography and cardiac computed tomographic angiography confirmed unruptured left-coronary and non-coronary SVAs. The left anterior descending artery and left circumflex artery were stretched and compressed by the SVA which causing myocardial ischemia. The patient finally received aortic root replacement (Bentall procedure) and got symptom relieved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Giant unruptured SVA originating from left coronary sinus is extremely rare. Our case highlights that giant SVA should be considered in cases with angina pectoris. Echocardiography and coronary computed tomographic angiography are useful and important for diagnosis. Surgery is highly recommended in patients with SVA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02730-x","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T06:02:08Z","timestamp":1713592928000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Giant unruptured sinus of Valsalva aneurysms causing angina pectoris"],"prefix":"10.1186","volume":"19","author":[{"given":"Peng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhedong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"2730_CR1","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1001\/jama.1914.02560490024006","volume":"62","author":"W Smith","year":"1914","unstructured":"Smith W. Aneurysm of the sinus of Valsalva with report of two cases. JAMA. 1914;62:1878.","journal-title":"JAMA"},{"key":"2730_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/clc.22359","volume":"38","author":"M Weinreich","year":"2015","unstructured":"Weinreich M, Yu P-J, Trost B. Sinus of Valsalva aneurysms: review of the literature and an update on management. Clin Cardiol. 2015;38:185\u20139.","journal-title":"Clin Cardiol"},{"key":"2730_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.athoracsur.2007.03.022","volume":"84","author":"Z Wang","year":"2007","unstructured":"Wang Z, Zou C, Li D, Li H, Wang A, Yuan G, et al. Surgical repair of sinus of Valsalva aneurysm in Asian patients. 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Congenital heart surgery nomenclature and database project: aortic aneurysm, sinus of Valsalva aneurysm, and aortic dissection. Ann Thorac Surg. 2000;69:S147\u2013163.","journal-title":"Ann Thorac Surg"},{"key":"2730_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/echo.13423","volume":"34","author":"K Chigurupati","year":"2017","unstructured":"Chigurupati K, Kumaresan B, Gadhinglajkar S, Sreedhar R. Multiple unruptured aortic sinus of Valsalva aneurysms: a rare presentation. Echocardiography. 2017;34:317\u20139.","journal-title":"Echocardiography"},{"key":"2730_CR10","doi-asserted-by":"publisher","first-page":"1120633","DOI":"10.3389\/fcvm.2023.1120633","volume":"10","author":"C Zhou","year":"2023","unstructured":"Zhou C, Tao J, Li S. Case report: unruptured sinus of Valsalva aneurysms causing postural angina pectoris and false pulmonary hypertension. 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Written informed consent was obtained from the individuals for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"251"}}