{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:25:37Z","timestamp":1772166337661,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fungal endocarditis is a rare but serious condition associated with high mortality rates. Various predisposing factors contribute to its occurrence, such as underlying cardiac abnormalities, cardiac surgeries, prosthetic cardiac devices, and central venous catheters. Diagnosing fungal endocarditis, particularly Aspergillus, poses challenges, often complicated by negative blood cultures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This report details a case of extensive ascending aorta involvement in Aspergillus endocarditis (AE) in a 24-year-old man with a history of bioprosthesis aortic valve replacement (AVR). Three months post-AVR, he presented with pericardial effusion and aortic rupture, leading to a redo biological valved conduit aortic root replacement (Bentall surgery). Despite the intervention, the tubular graft exhibited extensive Aspergillus involvement, resulting in graft disruption and significant peri-aortic infection. A second redo procedure involving aortic homograft root replacement was performed. Unfortunately, the patient succumbed two days after the surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A combined approach of medical and surgical therapies is recommended to manage fungal endocarditis. Despite efforts, the mortality rate associated with Aspergillus endocarditis remains unacceptably high, with no significant difference observed between combination therapy and antifungal treatment alone. Further research is essential to explore novel therapeutic strategies and improve outcomes for patients with this challenging condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-024-02733-8","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:02:43Z","timestamp":1712563363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Devastating fungal endocarditis involving ascending aorta in a patient with a history of aortic valve replacement: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Parisa","family":"Koohsari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Nakhaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrzad","family":"Rahmanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faeze","family":"Salahshour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roya","family":"Parkhideh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnoosh","family":"Larti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"issue":"1","key":"2733_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1378\/chest.122.1.302","volume":"122","author":"LC Pierrotti","year":"2002","unstructured":"Pierrotti LC, Baddour LM. Fungal endocarditis, 1995\u20132000. Chest. 2002;122(1):302\u201310.\u00a0Available from:\u00a0\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/12114375\/.\u00a0[Cited 2023 Aug 2].","journal-title":"Chest."},{"issue":"SUPPL. B","key":"2733_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/eurheartj\/16.suppl_B.84","volume":"16 Suppl B","author":"E Rubinstein","year":"1995","unstructured":"Rubinstein E, Lang R. Fungal endocarditis. Eur Heart J. 1995;16 Suppl B(SUPPL. B):84\u20139. Available from:\u00a0\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/7671932\/.\u00a0[Cited 2023 Aug 2].","journal-title":"Eur Heart J"},{"issue":"1","key":"2733_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1086\/317550","volume":"32","author":"ME Ellis","year":"2001","unstructured":"Ellis ME, Al-Abdely H, Sandridge A, Greer W, Ventura W. Fungal endocarditis: evidence in the world literature, 1965\u20131995. Clin Infect Dis. 2001;32(1):50\u201362. Available from:\u00a0\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/11118386\/.\u00a0[Cited 2023 Aug 2].","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2733_CR4","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.athoracsur.2010.06.103","volume":"90","author":"PG Malvindi","year":"2010","unstructured":"Malvindi PG, Van Putte BP, Heijmen RH, Schepens MAAM, Morshuis WJ. Reoperations for aortic false aneurysms after cardiac surgery. Ann Thorac Surg. 2010;90(5):1437\u201343. Available from:\u00a0\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/20971235\/.\u00a0[Cited 2023 Aug 2].","journal-title":"Ann Thorac Surg."},{"key":"2733_CR5","doi-asserted-by":"crossref","unstructured":"Meshaal MS, Labib D, Said K, Hosny M, Hassan M, Abd Al Aziz S, et al. Aspergillus endocarditis: Diagnostic criteria and predictors of outcome, A retrospective cohort study. PLoS One. 2018;13(8). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30092074\/. [Cited 2023 Aug 2].","DOI":"10.1371\/journal.pone.0201459"},{"issue":"44","key":"2733_CR6","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","volume":"36","author":"G Habib","year":"2015","unstructured":"Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075\u2013123.\u00a0Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/26320109\/. [Cited 2023 Aug 2].","journal-title":"Eur Heart J"},{"issue":"10","key":"2733_CR7","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1111\/echo.15430","volume":"39","author":"A Nakhaee","year":"2022","unstructured":"Nakhaee A, Parkhideh R, Rahmanian M, Pouraliakbar H, Sardari A, Larti F, et al. Re-emphasis on the role of echocardiography in the diagnosis of aortic root surgery complications. Echocardiography. 2022;39(10):1344\u20137.\u00a0Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/36198100\/.\u00a0[Cited 2023 Aug 2].","journal-title":"Echocardiography"},{"issue":"5","key":"2733_CR8","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jacc.2008.01.077","volume":"53","author":"GM Feuchtner","year":"2009","unstructured":"Feuchtner GM, Stolzmann P, Dichtl W, Schertler T, Bonatti J, Scheffel H, et al. Multislice computed tomography in infective endocarditis: comparison with transesophageal echocardiography and intraoperative findings. J Am Coll Cardiol. 2009;53(5):436\u201344.\u00a0Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/19179202\/.\u00a0[Cited 2023 Aug 2].","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2733_CR9","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00330-012-2491-5","volume":"22","author":"E Fagman","year":"2012","unstructured":"Fagman E, Perrotta S, Bech-Hanssen O, Flinck A, Lamm C, Olaison L, et al. ECG-gated computed tomography: a new role for patients with suspected aortic prosthetic valve endocarditis. Eur Radiol. 2012;22(11):2407\u201314.\u00a0Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/22622348\/. [Cited 2023 Aug 2].","journal-title":"Eur Radiol"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02733-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-02733-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02733-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:04:44Z","timestamp":1712563484000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-02733-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2733"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-02733-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3599676\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"12 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Medical Ethics Committee of Tehran University of Medical Sciences approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient and his legal executors. They were reassured that all information remains confidential.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"191"}}