{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:49:15Z","timestamp":1790214555094,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neurofibromatosis type 1 is a genetic disease that affects multiple organs and systems, leading to various clinical manifestations. In Neurofibromatosis type 1, rare intrathoracic meningoceles often occur alongside bone dysplasia. These meningoceles contain cerebrospinal fluid and can be mistakenly diagnosed as \u2018pleural effusion\u2019.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this case report, we mistakenly identified \u2018cerebrospinal fluid\u2019 as \u2018pleural effusion\u2019 and proceeded with drainage. This error posed significant risks to the patient and holds valuable implications for the future diagnosis and treatment of similar patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In patients with Neurofibromatosis type 1 complicated by spinal deformity, there is a high incidence of intrathoracic meningoceles. Treatment strategies may differ based on the specific features of the lesions, and collaboration among multiple disciplines can significantly improve patient outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02819-3","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:07:37Z","timestamp":1717042057000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurofibromatosis type 1 with huge intrathoracic meningoceles misdiagnosed as pleural effusion: A case report and literature review"],"prefix":"10.1186","volume":"19","author":[{"given":"Ningyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"2819_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/S1474-4422(14)70063-8","volume":"13","author":"AC Hirbe","year":"2014","unstructured":"Hirbe AC, Gutmann DH. Neurofibromatosis type 1: a multidisciplinary approach to care. Lancet Neurol. 2014;13:834\u201343.","journal-title":"Lancet Neurol"},{"key":"2819_CR2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/S1474-4422(07)70075-3","volume":"6","author":"RE Ferner","year":"2007","unstructured":"Ferner RE. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol. 2007;6:340\u201351.","journal-title":"Lancet Neurol"},{"key":"2819_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3390\/metabo13020255","volume":"13","author":"R Modica","year":"2023","unstructured":"Modica R, Altieri B, D\u2019Aniello F, Benevento E, Cannavale G, Minotta R, et al. Vitamin D and bone metabolism in adult patients with neurofibromatosis type 1. Metabolites. 2023;13:255.","journal-title":"Metabolites"},{"key":"2819_CR4","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/S0140-6736(03)13166-2","volume":"361","author":"RM Reynolds","year":"2003","unstructured":"Reynolds RM, Browning GGP, Nawroz I, Campbell IW. Von Recklinghausen\u2019s neurofibromatosis: neurofibromatosis type 1. Lancet. 2003;361:1552\u20134.","journal-title":"Lancet"},{"key":"2819_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0218492312475293","volume":"22","author":"T Zuo","year":"2014","unstructured":"Zuo T, Ni Z, Zhou M, Huang C, Tang Z, Yang Z. Large intrathoracic meningocele in a patient with neurofibromatosis type 1. Asian Cardiovasc Thorac Ann. 2014;22:219\u201321.","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2819_CR6","first-page":"CASE21404","volume":"2","author":"CHF Sum","year":"2021","unstructured":"Sum CHF, Li L-F, Taw BBT, Lui W-M, Sit K-Y, Chow VLY, et al. Surgical repair of a large intrathoracic meningocele associated with neurofibromatosis type 1 after failed cystoperitoneal shunts: illustrative case. J Neurosurgery: Case Lessons. 2021;2:CASE21404.","journal-title":"J Neurosurgery: Case Lessons"},{"key":"2819_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40981-024-00697-1","volume":"10","author":"R Nakazawa","year":"2024","unstructured":"Nakazawa R, Masui K, Goto T. Anesthesia management for thoracoscopic resection of a huge intrathoracic meningocele: a case report. JA Clin Rep. 2024;10:14.","journal-title":"JA Clin Rep"},{"key":"2819_CR8","doi-asserted-by":"publisher","first-page":"e31718","DOI":"10.1097\/MD.0000000000031718","volume":"101","author":"Y-R Kang","year":"2022","unstructured":"Kang Y-R, Hong S-M, Choi J-H, Lee S-J, Kim J-M, Wook Kang K, et al. Sensory neuronopathy in a patient with neurofibromatosis type 1. Medicine. 2022;101:e31718.","journal-title":"Medicine"},{"key":"2819_CR9","doi-asserted-by":"publisher","first-page":"106996","DOI":"10.1016\/j.clineuro.2021.106996","volume":"210","author":"K Lehner","year":"2021","unstructured":"Lehner K, Lubelski D, Witham T, Luciano M, Tuffaha S, Yang R, et al. Multidisciplinary approach for repair of a large ventral thoracic meningocele in neurofibromatosis-1; a systematic review of the literature and case report. Clin Neurol Neurosurg. 2021;210:106996.","journal-title":"Clin Neurol Neurosurg"},{"key":"2819_CR10","doi-asserted-by":"publisher","first-page":"e19631","DOI":"10.1097\/MD.0000000000019631","volume":"99","author":"Y Wang","year":"2020","unstructured":"Wang Y, He B, Yang J, Xu J, Liu J, Huang S. Individualized management of giant anterior meningoceles-case series. Medicine. 2020;99:e19631.","journal-title":"Medicine"},{"key":"2819_CR11","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.wneu.2019.05.204","volume":"129","author":"LN Close","year":"2019","unstructured":"Close LN, Park B, Woodroffe RW, Hitchon PW. Thoracic meningocele and cervical Syringomyelia treated with Ventriculoperitoneal Shunt. World Neurosurg. 2019;129:322\u20136.","journal-title":"World Neurosurg"},{"key":"2819_CR12","first-page":"291","volume":"27","author":"P Das","year":"2017","unstructured":"Das P, Goyal T, Hunt MA. Intrathoracic meningocele associated with neurofibromatosis type 1 and a novel technique for surgical repair: case report. J Neurosurgery: Spine. 2017;27:291\u20134.","journal-title":"J Neurosurgery: Spine"},{"key":"2819_CR13","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3340\/jkns.2016.59.6.650","volume":"59","author":"HP Malla","year":"2016","unstructured":"Malla HP, Park BJ, Koh JS, Jo DJ. Giant intrathoracic meningocele and breast Cancer in a neurofibromatosis type I patient. J Korean Neurosurg Soc. 2016;59:650.","journal-title":"J Korean Neurosurg Soc"},{"key":"2819_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13019-015-0374-y","volume":"10","author":"DG Cho","year":"2015","unstructured":"Cho DG, Chang YJ, Cho KD, Hong JT. Collaborative treatment of huge intrathoracic meningoceles associated with neurofibromatosis type 1: a case report. J Cardiothorac Surg. 2015;10:161.","journal-title":"J Cardiothorac Surg"},{"key":"2819_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1749-8090-9-85","volume":"9","author":"H-C Chen","year":"2014","unstructured":"Chen H-C, Chang P-H, Jhang S-W, Wang B-Y. Thoracoscopic plication for a huge thoracic meningocele in a patient with neurofibromatosis. J Cardiothorac Surg. 2014;9:85.","journal-title":"J Cardiothorac Surg"},{"key":"2819_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4103\/2006-8808.135151","volume":"6","author":"A Yusuf","year":"2014","unstructured":"Yusuf A, Pillai A, Menon S, Panikar D. Massive spontaneous Hemothorax, Giant Intrathoracic Meningocele, and Kyphoscoliosis in neurofibromatosis type 1. J Surg Tech Case Rep. 2014;6:33.","journal-title":"J Surg Tech Case Rep"},{"key":"2819_CR17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.5090\/kjtcs.2011.44.5.383","volume":"44","author":"Y-J Kim","year":"2011","unstructured":"Kim Y-J, Cho H-M, Yoon C-S, Lee C-K, Lee T-Y, Seok J-P. Surgical Treatment of Thoracic Menigocele Associated with neurofibromatosis and Kyphoscoliosis. Korean J Thorac Cardiovasc Surg. 2011;44:383\u20136.","journal-title":"Korean J Thorac Cardiovasc Surg"},{"key":"2819_CR18","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1212\/WNL.0b013e31821d7667","volume":"76","author":"BP Walcott","year":"2011","unstructured":"Walcott BP, Kahle KT, Wain JC, Borges LF. Giant thoracic meningocele associated with neurofibromatosis 1. Neurology. 2011;76:1943\u20131943.","journal-title":"Neurology"},{"key":"2819_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1510\/icvts.2010.252676","volume":"12","author":"H Kaneda","year":"2011","unstructured":"Kaneda H, Saito T, Konobu T, Saito Y. Chest wall bleeding with giant intrathoracic meningocele in neurofibromatosis type 1. Interact Cardiovasc Thorac Surg. 2011;12:328\u201330.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2819_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.athoracsur.2010.01.071","volume":"91","author":"K Tanaka","year":"2011","unstructured":"Tanaka K, Shimizu K, Kakegawa S, Oshima K, Takeyoshi I. Cystoperitoneal Shunt for a giant Intrathoracic Meningocele under Local Anesthesia. Ann Thorac Surg. 2011;91:317\u20139.","journal-title":"Ann Thorac Surg"},{"key":"2819_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.surneu.2007.02.058","volume":"69","author":"DJ Vanhauwaert","year":"2008","unstructured":"Vanhauwaert DJ, Deruytter MJ. Cystoperitoneal shunt as alternative treatment for a giant thoracic meningocele in a patient with neurofibromatosis. Surg Neurol. 2008;69:535\u20137.","journal-title":"Surg Neurol"},{"key":"2819_CR22","unstructured":"de Andrade GC, Braga OP, Hisatugo MK-I. GIANT INTRATHORACIC MENINGOCELES ASSOCIATED WITH CUTANEOUS NEUROFIBROMATOSIS TYPE I. Arq Neuropsiquiatr."},{"key":"2819_CR23","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/S0967-5868(03)00003-1","volume":"10","author":"S Ebara","year":"2003","unstructured":"Ebara S, Yuzawa Y, Kinoshita T, Takahashi J, Nakamura I, Hirabayashi H, et al. A neurofibromatosis type 1 patient with severe kyphoscoliosis and intrathoracic meningocele. J Clin Neurosci. 2003;10:268\u201372.","journal-title":"J Clin Neurosci"},{"key":"2819_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/00024720-200212000-00018","volume":"15","author":"J Mizuno","year":"2002","unstructured":"Mizuno J, Nakagawa H, Yamada T, Watabe T. Intrathoracic Giant Meningocele developing Hydrothorax: a Case Report. J Spin Disord Tech. 2002;15:529\u201332.","journal-title":"J Spin Disord Tech"},{"key":"2819_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s776-002-8436-5","volume":"7","author":"S Nakai","year":"2002","unstructured":"Nakai S, Ibe S, Otani K. Paraparesis after excision of intrathoracic meningoceles in a patient with neurofibromatosis. J Orthop Sci. 2002;7:143\u20136.","journal-title":"J Orthop Sci"},{"key":"2819_CR26","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s00132-021-04130-8","volume":"50","author":"C-E Heyde","year":"2021","unstructured":"Heyde C-E, V\u00f6lker A, von der H\u00f6h NH, Glasmacher S, Koller H. Wirbels\u00e4ulendeformit\u00e4ten Bei Neurofibromatose Typ 1. Orthop\u00e4de. 2021;50:650\u20136.","journal-title":"Orthop\u00e4de"},{"key":"2819_CR27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3233\/CBM-130319","volume":"13","author":"J Li","year":"2013","unstructured":"Li J, Bao Q-L, Wang Y, Hu Y-M, Chen P. Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion. Cancer Biomarkers. 2013;13:49\u201358.","journal-title":"Cancer Biomarkers"},{"key":"2819_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1093\/ejcts\/ezt522","volume":"46","author":"JC Trujillo-Reyes","year":"2014","unstructured":"Trujillo-Reyes JC, Rami-Porta R, Navarro AK, Belda-Sanchis J. Tension pneumocephalus: a rare complication after resection of a neurogenic tumour by thoracoscopic surgery. Eur J Cardiothorac Surg. 2014;46:145.","journal-title":"Eur J Cardiothorac Surg"},{"key":"2819_CR29","doi-asserted-by":"crossref","unstructured":"Alves J\u00fanior SF, Irion KL, de Melo ASA, Meirelles G, de Rodrigues SP, Souza RS Jr. et al. AS,. Neurofibromatosis type 1: evaluation by chest computed tomography. Radiol Bras. 2021;54:375\u201380.","DOI":"10.1590\/0100-3984.2020.0150"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02819-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-02819-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-02819-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:11:16Z","timestamp":1717042276000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-02819-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2819"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-02819-3","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"20 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Human Research Ethics Committee of Northern Jiangsu Province Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of data was obtained from the patient. A copy of the consent form is available for review by the Editor of thejournal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"303"}}