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This study aimed to investigate the impact of minimal invasive extracorporeal circulation (MiECC) on the systemic inflammatory response compared with conventional extracorporeal circulation (CECC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients undergoing coronary artery bypass grafting were randomized to MiECC (<jats:italic>n<\/jats:italic>\u2009=\u200930) and CECC (<jats:italic>n<\/jats:italic>\u2009=\u200930). Primary endpoint was tumor necrosis factor-\u03b1. Secondary endpoints were other biochemical markers of inflammation (IL1\u03b2, IL6 and IL8, C-reactive protein, leukocytes), and markers of inadequate tissue perfusion and tissue damage (lactate dehydrogenase, lactate and creatine kinase-MB). In addition, we registered signs of systemic inflammatory response syndrome, haemodynamic instability, atrial fibrillation, respiratory dysfunction, and infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients treated with MiECC showed significantly lower levels of tumor necrosis factor-\u03b1 than CECC during and early after extracorporeal circulation (median: MiECC 3.4 pg\/mL; CI 2.2\u20134.5 vs. CECC 4.6 pg\/mL; CI 3.4\u20135.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Lower levels of creatine kinase-MB and lactate dehydrogenase suggested less tissue damage. However, we detected no other significant differences in any other markers of inflammation, tissue damage or in any of the clinical outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Lower levels of TNF-\u03b1 after MiECC compared with CECC may reflect reduced inflammatory response, although other biochemical markers of inflammation were comparable. Our results suggest better end-organ protection with MiECC compared with CECC. Clinical parameters related to systemic inflammatory response were comparable in this study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical registration number<\/jats:title>\n                <jats:p>NCT03216720.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-02903-8","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:03:44Z","timestamp":1719986624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of minimal invasive extracorporeal circulation on systemic inflammatory response \u2013 a randomized trial"],"prefix":"10.1186","volume":"19","author":[{"given":"Deborah Richards","family":"Halle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-0299","authenticated-orcid":false,"given":"Leila Louise","family":"Benhassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten Lund","family":"S\u00f8berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Fast","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Henrik","family":"Kimose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Michael","family":"Hasenkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy Susanne","family":"Modrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"issue":"4","key":"2903_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S1010-7940(02)00372-X","volume":"22","author":"Y Fromes","year":"2002","unstructured":"Fromes Y, Gaillard D, Ponzio O, Chauffert M, Gerhardt M-F, Deleuze P, et al. 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