{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:29:25Z","timestamp":1774067365883,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"DOI":"10.1186\/s13019-024-03018-w","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:04:11Z","timestamp":1726045451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A retrospective study on safety and efficacy of recombinant human soluble thrombomodulin to acute aortic dissection with disseminated intravascular coagulation"],"prefix":"10.1186","volume":"19","author":[{"given":"Tsukasa","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masateru","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Imazuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"3018_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1136\/bmj.1.6052.24","volume":"1","author":"J Scott","year":"1977","unstructured":"Scott J, Humphreys DR. Dissecting aortic aneurysm and disseminated intravascular coagulation. Br Med J. 1977;1:24.","journal-title":"Br Med J"},{"key":"3018_CR2","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.jacc.2004.04.053","volume":"44","author":"H Eggebrecht","year":"2004","unstructured":"Eggebrecht H, Naber CK, Bruch C, Kr\u00f6ger K, von Birgelen C, Schmermund A, et al. Value of plasma fibrin D-dimers for detection of acute aortic dissection. J Am Coll Cardiol. 2004;44:804\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"3018_CR3","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1136\/hrt.2005.072959","volume":"92","author":"T Weber","year":"2006","unstructured":"Weber T, Rammer M, Auer J, Maurer E, Asp\u00f6ck G, Eber B. Plasma concentrations of D-dimer predict mortality in acute type A aortic dissection. Heart. 2006;92:836\u20137.","journal-title":"Heart"},{"key":"3018_CR4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"GR Bernard","year":"2001","unstructured":"Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699\u2013709.","journal-title":"N Engl J Med"},{"key":"3018_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1538-7836.2006.02267.x","volume":"5","author":"H Saito","year":"2007","unstructured":"Saito H, Maruyama I, Shimazaki S, Yamamoto Y, Aikawa N, Ohno R, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost. 2007;5:31\u201341.","journal-title":"J Thromb Haemost"},{"key":"3018_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1055\/s-0038-1676345","volume":"119","author":"K Yamakawa","year":"2019","unstructured":"Yamakawa K, Murao S, Aihara M. Recombinant human soluble thrombomodulin in sepsis-induced coagulopathy: an updated systematic review and meta-analysis. Thromb Haemost. 2019;119:56\u201365.","journal-title":"Thromb Haemost"},{"key":"3018_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.thromres.2016.09.011","volume":"147","author":"S Tawara","year":"2016","unstructured":"Tawara S, Sakai T, Matsuzaki O. Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin. Thromb Res. 2016;147:72\u20139.","journal-title":"Thromb Res"},{"key":"3018_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12959-016-0117-x","volume":"14","author":"H Asakura","year":"2016","unstructured":"Asakura H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, et al. Proposal for new diagnostic criteria for DIC from the Japanese society on thrombosis and Hemostasis. Thromb J. 2016;14:42.","journal-title":"Thromb J"},{"key":"3018_CR9","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1001\/archsurg.1983.01390110010002","volume":"118","author":"DF Fisher Jr","year":"1983","unstructured":"Fisher DF Jr, Yawn DH, Crawford ES. Preoperative disseminated intravascular coagulation associated with aortic aneurysms. A prospective study of 76 cases. Arch Surg. 1983;118:1252\u20135.","journal-title":"Arch Surg"},{"key":"3018_CR10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4326\/jjcvs.42.267","volume":"42","author":"H Koike","year":"2013","unstructured":"Koike H, Iguchi A, Nakajima H, Uebe K, Asakura T, Morita K, et al. Clinical experience with recombinant thrombomodulin in patients undergoing cardiovascular surgery complicated by disseminated intravascular coagulopathy. Jpn J Cardiovasc Surg. 2013;42:267\u201373.","journal-title":"Jpn J Cardiovasc Surg"},{"key":"3018_CR11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13019-022-01785-y","volume":"17","author":"JX Wang","year":"2022","unstructured":"Wang JX, Xue YX, Zhu XY, Chong HS, Chen Z, Zhou Q, et al. The impact of age in acute type A aortic dissection: a retrospective study. J Cardiothorac Surg. 2022;17:40.","journal-title":"J Cardiothorac Surg"},{"key":"3018_CR12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S1010-7940(99)00170-0","volume":"16","author":"Y Okita","year":"1999","unstructured":"Okita Y, Ando M, Minatoya K, Tagusari O, Kitamura S, Nakajjma N, et al. Early and long-term results of surgery for aneurysms of the thoracic aorta in septuagenarians and octogenarians. Eur J Cardiothorac Surg. 1999;16:317\u201323.","journal-title":"Eur J Cardiothorac Surg"},{"key":"3018_CR13","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1172\/JCI22782","volume":"115","author":"K Abeyama","year":"2005","unstructured":"Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, Tanaka M, et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest. 2005;115:1267\u201374.","journal-title":"J Clin Invest"},{"key":"3018_CR14","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13019-018-0731-8","volume":"13","author":"E Yin","year":"2018","unstructured":"Yin E, Matsuyama S, Uchiyama M, Kawai K, Niimi M. Graft protective effect and induction of CD4+Foxp3+ cell by Thrombomodulin on allograft arteriosclerosis in mice. J Cardiothorac Surg. 2018;13:48.","journal-title":"J Cardiothorac Surg"},{"key":"3018_CR15","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.transproceed.2021.12.024","volume":"5","author":"Y Yamamoto","year":"2022","unstructured":"Yamamoto Y, Ikeda T, Uchiyama M, Iguchi K, Imazuru T, Shimokawa T. Effects of each domain in recombinant human soluble thrombomodulin on prolongation of murine cardiac allograft survival. Transplant Proc. 2022;5:487\u201391.","journal-title":"Transplant Proc"},{"key":"3018_CR16","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/01.CCM.0000202209.42491.38","volume":"34","author":"S Gando","year":"2006","unstructured":"Gando S, Iba T, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006;34:625\u201331.","journal-title":"Crit Care Med"},{"key":"3018_CR17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s13019-021-01623-7","volume":"16","author":"G Liu","year":"2021","unstructured":"Liu G, Wang H, Luo Q, Cao L, Yang L, Yu C, et al. Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection. J Cardiothorac Surg. 2021;16:274.","journal-title":"J Cardiothorac Surg"},{"key":"3018_CR18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13019-022-01818-6","volume":"17","author":"Z Tang","year":"2022","unstructured":"Tang Z, Liu H, Shao Y. Efficacy of CRP in combination with D-dimer in predicting adverse postoperative outcomes of patients with acute Stanford type A aortic dissection. J Cardiothorac Surg. 2022;17:71.","journal-title":"J Cardiothorac Surg"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03018-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-03018-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03018-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:09:17Z","timestamp":1726045757000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-03018-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3018"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-03018-w","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"30 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients provided informed consent, and the study protocol was approved by the Ethics Committee of Teikyo University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Written consent was obtained from all patients for writing this study and accompanying data. Identifying details have been omitted.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"523"}}