{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:47:46Z","timestamp":1769017666431,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"DOI":"10.1186\/s13019-024-03032-y","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T03:39:55Z","timestamp":1726285195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical significance of postoperative thrombocytosis after vats lobectomy for NSCLC"],"prefix":"10.1186","volume":"19","author":[{"given":"Beatrice","family":"Leonardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Natale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Ferraioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Leone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Grande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Puca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rainone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetana","family":"Messina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Sica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Fiorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"issue":"1","key":"3032_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12890-020-1139-5","volume":"20","author":"Y Yuan","year":"2020","unstructured":"Yuan Y, Zhong H, Ye L, Li Q, Fang S, Gu W, Qian Y. Prognostic value of pretreatment platelet counts in lung cancer: a systematic review and meta-analysis. BMC Pulm Med. 2020;20(1):96.","journal-title":"BMC Pulm Med"},{"issue":"7","key":"3032_CR2","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1111\/1759-7714.14287","volume":"13","author":"C Andreetti","year":"2022","unstructured":"Andreetti C, Ibrahim M, Gagliardi A, et al. Adjuvant chemotherapy, extent of resection, and immunoistochemical neuroendocrine markers as prognostic factors of early-stage large-cell neuroendocrine carcinoma. Thorac Cancer. 2022;13(7):900\u201312.","journal-title":"Thorac Cancer"},{"issue":"9","key":"3032_CR3","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1111\/1759-7714.13949","volume":"12","author":"A Fiorelli","year":"2021","unstructured":"Fiorelli A, Forte S, Natale G, Santini M, Fang W. Handling benign interlobar lymphadenopathy during thoracoscopic lobectomy. Thorac Cancer. 2021;12(9):1489\u201392.","journal-title":"Thorac Cancer"},{"issue":"35","key":"3032_CR4","doi-asserted-by":"publisher","first-page":"e30275","DOI":"10.1097\/MD.0000000000030275","volume":"101","author":"S Xia","year":"2022","unstructured":"Xia S, Wu W, Yu L, Ma L, Chen S, Wang H. Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: a systematic review and meta-analysis. Med (Baltim). 2022;101(35):e30275.","journal-title":"Med (Baltim)"},{"issue":"2","key":"3032_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cllc.2022.12.012","volume":"24","author":"B Sandfeld-Paulsen","year":"2023","unstructured":"Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A. Pretreatment Platelet Count is a prognostic marker in Lung Cancer: a Danish Registry-based Cohort Study. Clin Lung Cancer. 2023;24(2):175\u201383.","journal-title":"Clin Lung Cancer"},{"issue":"22","key":"3032_CR6","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.2169\/internalmedicine.9282-21","volume":"61","author":"Y Edahiro","year":"2022","unstructured":"Edahiro Y, Kurokawa Y, Morishita S, Yamamoto T, Araki M, Komatsu N. Causes of thrombocytosis: a single-center Retrospective Study of 1,202 patients. Intern Med. 2022;61(22):3323\u20138. https:\/\/doi.org\/10.2169\/internalmedicine.9282-21. Epub 2022 Nov 15.","journal-title":"Intern Med"},{"issue":"3","key":"3032_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3892\/mco.2017.1342","volume":"7","author":"Y Yu","year":"2017","unstructured":"Yu Y, Qian L, Cui J. Value of neutrophil-to-lymphocyte ratio for predicting lung cancer prognosis: a meta-analysis of 7,219 patients. Mol Clin Oncol. 2017;7(3):498\u2013506.","journal-title":"Mol Clin Oncol"},{"issue":"7","key":"3032_CR8","doi-asserted-by":"publisher","first-page":"e0200341","DOI":"10.1371\/journal.pone.0200341","volume":"13","author":"JU Lim","year":"2018","unstructured":"Lim JU, Yeo CD, Kang HS, Park CK, Kim JS, Kim JW, Kim SJ, Lee SH. Prognostic value of platelet count and lymphocyte to monocyte ratio combination in stage IV non-small cell lung cancer with malignant pleural effusion. PLoS ONE. 2018;13(7):e0200341.","journal-title":"PLoS ONE"},{"key":"3032_CR9","doi-asserted-by":"publisher","first-page":"962173","DOI":"10.3389\/fonc.2022.962173","volume":"12","author":"K Zhou","year":"2022","unstructured":"Zhou K, Cao J, Lin H, Liang L, Shen Z, Wang L, Peng Z, Mei J. Prognostic role of the platelet to lymphocyte ratio (PLR) in the clinical outcomes of patients with advanced lung cancer receiving immunotherapy: a systematic review and meta-analysis. Front Oncol. 2022;12:962173.","journal-title":"Front Oncol"},{"issue":"3","key":"3032_CR10","doi-asserted-by":"publisher","first-page":"227","DOI":"10.21037\/atm-20-6710","volume":"9","author":"E Keit","year":"2021","unstructured":"Keit E, Coutu B, Zhen W, Zhang C, Lin C, Bennion N, Ganti AK, Ernani V, Baine M. Systemic inflammation is associated with inferior disease control and survival in stage III non-small cell lung cancer. Ann Transl Med. 2021;9(3):227.","journal-title":"Ann Transl Med"},{"issue":"7","key":"3032_CR11","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1080\/09537104.2020.1810653","volume":"32","author":"Y Ma","year":"2021","unstructured":"Ma Y, Li G, Yu M, Sun X, Nian J, Gao Y, Li X, Ding T, Wang X. Prognostic significance of thrombocytosis in lung cancer: a systematic review and meta-analysis. Platelets. 2021;32(7):919\u201327.","journal-title":"Platelets"},{"issue":"5","key":"3032_CR12","doi-asserted-by":"publisher","first-page":"e1702","DOI":"10.1002\/wnan.1702","volume":"13","author":"M Geranpayehvaghei","year":"2021","unstructured":"Geranpayehvaghei M, Dabirmanesh B, Khaledi M, et al. Cancer-associated-platelet-inspired nanomedicines for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021;13(5):e1702.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"2","key":"3032_CR13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10555-017-9673-1","volume":"36","author":"MZ Wojtukiewicz","year":"2017","unstructured":"Wojtukiewicz MZ, Sierko E, Hempel D, Tucker SC, Honn KV. Platelets and cancer angiogenesis nexus. Cancer Metastasis Rev. 2017;36(2):249\u201362.","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"3032_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13019-022-01844-4","volume":"17","author":"G Messina","year":"2022","unstructured":"Messina G, Bove M, Noro A, Opromolla G, Natale G, Leone F, Di Filippo V, Leonardi B, Martone M, Pirozzi M, Caterino M, Facchini S, Zotta A, Vicidomini G, Santini M, Fiorelli A, Corte Carminia D, Ciardiello F, Fasano M. Prediction of preoperative intrathoracic adhesions for ipsilateral reoperations: sliding lung sign. J Cardiothorac Surg. 2022;17(1):103.","journal-title":"J Cardiothorac Surg"},{"key":"3032_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijsu.2015.03.005","volume":"18","author":"V Josa","year":"2015","unstructured":"Josa V, Krzystanek M, Eklund AC, Salamon F, Zarand A, Szallasi Z, Baranyai Z. Relationship of postoperative thrombocytosis and survival of patients with colorectal cancer. Int J Surg. 2015;18:1\u20136.","journal-title":"Int J Surg"},{"issue":"4","key":"3032_CR16","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1245\/s10434-023-14844-y","volume":"31","author":"B Milojevic","year":"2024","unstructured":"Milojevic B, Janicic A, Grozdic Milojevic I, et al. Prognostic impact of preoperative thrombocytosis on recurrence-free survival in patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol. 2024;31(4):2538\u201344.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"3032_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1055\/s-0042-1748025","volume":"71","author":"TJ Holleran","year":"2023","unstructured":"Holleran TJ, Napolitano MA, Duggan JP, Peters AS, Amdur RL, Antevil JL, Trachiotis GD. Predictors of 30-Day Pulmonary complications after Video-assisted thoracoscopic surgery lobectomy. Thorac Cardiovasc Surg. 2023;71(4):327\u201335.","journal-title":"Thorac Cardiovasc Surg"},{"issue":"1","key":"3032_CR18","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1038\/s41598-022-11045-7","volume":"12","author":"A Rashid","year":"2022","unstructured":"Rashid A, Zeng C, Motta-Ribeiro G, Dillon ST, Libermann TA, Lessa MA, Bagchi A, Hutchinson J, Vidal Melo MF. Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions. Sci Rep. 2022;12(1):7065.","journal-title":"Sci Rep"},{"issue":"3","key":"3032_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/0218492320974184","volume":"29","author":"A Fiorelli","year":"2021","unstructured":"Fiorelli A, Cascone R, Carlucci A, Natale G, Freda C, Bove M, Messina G, Liguori G, Santini M. Uniportal thoracoscopic surgical management using a suture traction for primary pneumothorax. Asian Cardiovasc Thorac Ann. 2021;29(3):195\u2013202.","journal-title":"Asian Cardiovasc Thorac Ann"},{"issue":"6","key":"3032_CR20","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.21037\/jtd.2017.05.78","volume":"9","author":"M De Waele","year":"2017","unstructured":"De Waele M, Agzarian J, Hanna WC, Schieman C, Finley CJ, Macri J, Schneider L, Schnurr T, Farrokhyar F, Radford K, Nair P, Shargall Y. Does the usage of digital chest drainage systems reduce pleural inflammation and volume of pleural effusion following oncologic pulmonary resection? - a prospective randomized trial. J Thorac Dis. 2017;9(6):1598\u2013606.","journal-title":"J Thorac Dis"},{"issue":"1","key":"3032_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/crj.13098","volume":"14","author":"A Fiorelli","year":"2020","unstructured":"Fiorelli A, Natale G, Freda C, Cascone R, Carlucci A, Costanzo S, Ferrara V, Santini M. Montgomery T-tube for management of tracheomalacia: impact on voice-related quality of life. Clin Respir J. 2020;14(1):40\u20136.","journal-title":"Clin Respir J"},{"issue":"4","key":"3032_CR22","first-page":"5379","volume":"8","author":"X Zhang","year":"2015","unstructured":"Zhang X, Ran Y. Prognostic role of elevated platelet count in patients with lung cancer: a systematic review and meta-analysis. Int J Clin Exp Med. 2015;8(4):5379\u201387.","journal-title":"Int J Clin Exp Med"},{"issue":"15","key":"3032_CR23","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.7150\/jca.20866","volume":"8","author":"S Lee","year":"2017","unstructured":"Lee S, Eo W, Jeon H, Park S, Chae J. Prognostic significance of host-related biomarkers for survival in patients with Advanced Non-small Cell Lung Cancer. J Cancer. 2017;8(15):2974\u201383.","journal-title":"J Cancer"},{"issue":"4","key":"3032_CR24","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/1759-7714.13340","volume":"11","author":"C Liu","year":"2020","unstructured":"Liu C, Zhang H, Qi Q, Zhang B, Yue D, Wang C. The preoperative platelet distribution width: a predictive factor of the prognosis in patients with non-small cell lung cancer. Thorac Cancer. 2020;11(4):918\u201327.","journal-title":"Thorac Cancer"},{"issue":"9","key":"3032_CR25","first-page":"512","volume":"128","author":"P Skorek","year":"2018","unstructured":"Skorek P, St\u0119pie\u0144 K, Fila M, Hauer J, Ku\u017cd\u017ca\u0142 J. Preoperative thrombocytosis in surgically treated patients with non-small cell lung cancer. Pol Arch Intern Med. 2018;128(9):512\u20137.","journal-title":"Pol Arch Intern Med"},{"issue":"7","key":"3032_CR26","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1007\/s00262-023-03392-9","volume":"72","author":"M Li","year":"2023","unstructured":"Li M, Zhao S, Lopez G, Secor A, Das P, Surya N, Grogan M, Patel S, Chakravarthy K, Miah A, Spakowicz D, Tinoco G, Li Z, Wei L, He K, Bertino E, Alahmadi A, Memmott R, Kaufman J, Shields PG, Carbone DP, Presley CJ, Otterson GA, Owen DH. Mean platelet volume, thrombocytosis, and survival in non-small cell lung cancer patients treated with first-line pembrolizumab alone or with chemotherapy. Cancer Immunol Immunother. 2023;72(7):2067\u201374.","journal-title":"Cancer Immunol Immunother"},{"issue":"4","key":"3032_CR27","first-page":"937","volume":"31","author":"B Saha","year":"2022","unstructured":"Saha B, Khatun N, Azim N, Islam SA, Proteek MF, Islam MR, Begum FA, Biddut MA, Khan MK, Islam MR. Platelet count as a prognostic factor in Stage IV Non-small Cell Lung Cancer. Mymensingh Med J. 2022;31(4):937\u201346.","journal-title":"Mymensingh Med J"},{"issue":"4","key":"3032_CR28","first-page":"1725","volume":"33","author":"A Mar\u00e1z","year":"2013","unstructured":"Mar\u00e1z A, Fur\u00e1k J, Varga Z, Kah\u00e1n Z, Tiszlavicz L, Hidegh\u00e9ty K. Thrombocytosis has a negative prognostic value in lung cancer. Anticancer Res. 2013;33(4):1725\u20139.","journal-title":"Anticancer Res"},{"issue":"4","key":"3032_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.5482\/HAMO-16-06-0016","volume":"36","author":"RE Scharf","year":"2016","unstructured":"Scharf RE. Do we need antiplatelet therapy in thrombocytosis? Contra. Proposal for an individualized risk-adapted treatment. Hamostaseologie. 2016;36(4):241\u201360.","journal-title":"Hamostaseologie"},{"key":"3032_CR30","doi-asserted-by":"crossref","unstructured":"Madaan GB, Jairajpuri ZS, Hajini FF, Jetley S. Postoperative thrombocytosis: an unusual case report. Int J Appl Basic Med Res. 2015 Sep-Dec;5(3):225\u20137.","DOI":"10.4103\/2229-516X.165372"},{"key":"3032_CR31","doi-asserted-by":"publisher","first-page":"1978639","DOI":"10.1155\/2018\/1978639","volume":"2018","author":"M Mohamud","year":"2018","unstructured":"Mohamud M, Osborne L, Jones HG, Ahmed A, Beynon J, Harris DA, Evans M, Davies M, Khot U, Chandrasekaran TV. Thrombocytosis as a marker for postoperative complications in colorectal surgery. Gastroenterol Res Pract. 2018;2018:1978639.","journal-title":"Gastroenterol Res Pract"},{"issue":"3","key":"3032_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/1759-7714.14735","volume":"14","author":"G Messina","year":"2023","unstructured":"Messina G, Bove M, Natale G, Di Filippo V, Opromolla G, Rainone A, Leonardi B, Martone M, Fiorelli A, Vicidomini G, Santini M, Ronchi A, Massimilla E, Della Corte CM, Pirozzi M, Caterino M, Ciardiello F, Fasano M. Diagnosis of malignant pleural disease: Ultrasound as a detective probe. Thorac Cancer. 2023;14(3):223\u201330.","journal-title":"Thorac Cancer"},{"key":"3032_CR33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40364-020-00207-2","volume":"8","author":"Y Chen","year":"2020","unstructured":"Chen Y, Zhong H, Zhao Y, Luo X, Gao W. Role of platelet biomarkers in inflammatory response. Biomark Res. 2020;8:28.","journal-title":"Biomark Res"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03032-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-03032-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03032-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:48:57Z","timestamp":1748591337000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-03032-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3032"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-03032-y","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]},"assertion":[{"value":"1 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: the statement in the Funding information section was incorrect and it has been updated.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Boards of the University of Campania \u201cLuigi Vanvitelli\u201d waived the need for ethical approval due to the retrospective nature of the study since there was no modification to the standard of care for the patients. In all cases, informed written consent was obtained from the patients for the treatment and for the anonymous use and publication of their data for scientific purposes. All procedures were performed in accordance with international guidelines; with the Helsinki Declaration of 1975, revised in 1983; and the rules of the Italian laws of privacy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients signed an informed consent for the anonymous publications of their data for scientific purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"529"}}