{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:09:42Z","timestamp":1727842182570},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Patients can develop de novo malignancies following orthotopic heart transplantation. However, vascular tumors are not commonly described in this population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a 69-year-old female with a history of orthotopic heart transplantation for chemotherapy-induced cardiomyopathy who developed an incidental pulmonary artery mass six years after her transplantation. Given concerns for malignancy, the patient underwent an operative excisional biopsy through a left anterior mini-thoracotomy with femoral artery and vein cannulation for cardiopulmonary bypass. The mass was determined to be a non-malignant vascular overgrowth with <jats:italic>PIK3CA<\/jats:italic> mutation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We present the case of an unusual pulmonary artery mass with <jats:italic>PIK3CA<\/jats:italic> mutation found in a post heart transplant patient. We were able to spare her the morbidity of a redo-sternotomy by excising the mass via a minimally invasive left anterior thoracotomy approach.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-03090-2","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T07:02:12Z","timestamp":1727766132000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary artery mass with PIK3CA mutation after orthotopic heart transplantation"],"prefix":"10.1186","volume":"19","author":[{"given":"Andre Y.","family":"Son","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav A.","family":"Alexiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Thinh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"issue":"1","key":"3090_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jacc.2017.10.077","volume":"71","author":"JC Youn","year":"2018","unstructured":"Youn JC, Stehlik J, Wilk AR, et al. Temporal trends of De Novo Malignancy Development after Heart Transplantation. J Am Coll Cardiol. 2018;71(1):40\u20139. https:\/\/doi.org\/10.1016\/j.jacc.2017.10.077.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"3090_CR2","doi-asserted-by":"publisher","first-page":"e008968","DOI":"10.1161\/CIRCHEARTFAILURE.121.008968","volume":"15","author":"J Batra","year":"2022","unstructured":"Batra J, DeFilippis EM, Golob S, et al. Impact of Pretransplant Malignancy on Heart Transplantation outcomes: Contemporary United Network for Organ Sharing Analysis amidst evolving Cancer therapies. Circulation: Heart Fail. 2022;15(4):e008968. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.121.008968.","journal-title":"Circulation: Heart Fail"},{"issue":"1","key":"3090_CR3","doi-asserted-by":"publisher","first-page":"17082","DOI":"10.1038\/s41598-020-74086-w","volume":"10","author":"I Keraite","year":"2020","unstructured":"Keraite I, Alvarez-Garcia V, Garcia-Murillas I, et al. PIK3CA mutation enrichment and quantitation from blood and tissue. Sci Rep. 2020;10(1):17082. https:\/\/doi.org\/10.1038\/s41598-020-74086-w.","journal-title":"Sci Rep"},{"issue":"4","key":"3090_CR4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/ajmg.c.31735","volume":"181","author":"KM Keppler-Noreuil","year":"2019","unstructured":"Keppler-Noreuil KM, Lozier J, Oden N, et al. Thrombosis risk factors in PIK3CA-related overgrowth spectrum and Proteus syndrome. Am J Med Genet C Semin Med Genet. 2019;181(4):571\u201381. https:\/\/doi.org\/10.1002\/ajmg.c.31735.","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"4","key":"3090_CR5","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.athoracsur.2020.02.028","volume":"110","author":"V Bianco","year":"2020","unstructured":"Bianco V, Kilic A, Gleason TG, et al. Reoperative cardiac surgery is a risk factor for long-term mortality. Ann Thorac Surg. 2020;110(4):1235\u201342. https:\/\/doi.org\/10.1016\/j.athoracsur.2020.02.028.","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"3090_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1111\/jocs.15382","volume":"36","author":"SM Said","year":"2021","unstructured":"Said SM, Marey G, Hiremath G, Aggarwal V, Kloesel B, Griselli M. Pulmonary valve replacement via left anterior minithoracotomy: lessons learned and early experience. J Card Surg. 2021;36(4):1305\u201312. https:\/\/doi.org\/10.1111\/jocs.15382.","journal-title":"J Card Surg"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03090-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-03090-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03090-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T07:04:57Z","timestamp":1727766297000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-03090-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3090"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-03090-2","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"10 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Yes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"558"}}