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We aim to compare both systems for MR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Five databases were searched until October 2024. Original studies were only included and critically appraised using an adapted version of the Newcastle\u2013Ottawa scale for observational cohort studies and the Cochrane risk of bias tool for randomized controlled trials. The risk ratio (RR) and mean difference (MD) with their corresponding 95% confidence interval (95% CI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>From the database search, we identified 197 studies, of which eight studies comprising 1,612 patients who underwent transcatheter edge-to-edge repair with either MitraClip or PASCAL were included in this meta-analysis. The statistical analysis revealed no significant difference between the two devices in achieving a two-grade reduction in MR severity (RR\u2009=\u20090.95; 95% CI: [0.86, 1.04]; p\u2009=\u20090.28), one-grade reduction (RR\u2009=\u20091.17; 95% CI: [0.92, 1.49]; p\u2009=\u20090.19), or in cases with no improvement (RR\u2009=\u20091.23; 95% CI: [0.79, 1.90]; p\u2009=\u20090.36). Additionally, there were no significant differences between PASCAL and MitraClip regarding procedure time, procedural success, reinterventions, or all-cause mortality. However, PASCAL trended towards better residual MR reduction, although this was accompanied by moderate heterogeneity. Both devices demonstrated comparable safety profiles and were effective in reducing MR and improving cardiac function.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MitraClip and PASCAL devices showed comparable safety profiles and procedural success rates. However, the analysis did not reveal a statistically significant difference between the two devices in reducing the severity of MR.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-024-03218-4","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:47:50Z","timestamp":1735897670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair"],"prefix":"10.1186","volume":"20","author":[{"given":"Mahmoud","family":"Balata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ibrahim","family":"Gbreel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Hamouda","family":"Elkasaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Ulrich","family":"Becher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"3218_CR1","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/S0140-6736(18)30473-2","volume":"391","author":"V Dziadzko","year":"2018","unstructured":"Dziadzko V, Clavel M-A, Dziadzko M, Medina-Inojosa JR, Michelena H, Maalouf J, et al. 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