{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:21:15Z","timestamp":1785799275584,"version":"3.56.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Top-level Clinical Discipline Project of Shanghai Pudong District","award":["PWYgf 2021-01"],"award-info":[{"award-number":["PWYgf 2021-01"]}]},{"name":"Top-level Clinical Discipline Project of Shanghai Pudong District","award":["PWYgf 2021-01"],"award-info":[{"award-number":["PWYgf 2021-01"]}]},{"name":"Shanghai Key clinical specialty Project","award":["shslczdzk06202"],"award-info":[{"award-number":["shslczdzk06202"]}]},{"name":"Shanghai Key clinical specialty Project","award":["shslczdzk06202"],"award-info":[{"award-number":["shslczdzk06202"]}]},{"name":"Science and Technology Plan of Jiangxi Provincial Health Commission","award":["SKJP220218066"],"award-info":[{"award-number":["SKJP220218066"]}]},{"name":"Science and Technology Plan of Jiangxi Provincial Health Commission","award":["SKJP220218066"],"award-info":[{"award-number":["SKJP220218066"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and OSA remains unclear. The purpose of this study was to clarify whether CPAP can improve arterial stiffness and inflammatory factor levels in CHD patients with OSA, and to further improve prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>59 patients with coronary heart disease complicated by moderate to severe sleep apnea were divided into a CPAP treatment group (CPAP\u2009+\u2009coronary heart disease standard treatment) and a control group (only coronary heart disease standard treatment). Peripheral blood test reports were collected and pulse wave velocity (PWV) measurements were performed for each patient at the beginning, 3 months, and 6 months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 6 months of treatment, the CPAP group showed more significant improvement in the levels of inflammatory factors such as white blood cell (WBC), neutrophil (N), C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), and PWV than the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After active treatment with CPAP, arterial stiffness and inflammatory cytokine levels in patients with coronary heart disease and OSA improved. This association should be given more attention in clinical practice, and sleep apnea should be actively treated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-024-03252-2","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:51:23Z","timestamp":1736556683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea"],"prefix":"10.1186","volume":"20","author":[{"given":"Liang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakibur Rahman","family":"Tapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"issue":"15","key":"3252_CR1","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1056\/NEJMcp1816152","volume":"380","author":"SC Veasey","year":"2019","unstructured":"Veasey SC, Rosen IM. Obstructive sleep apnea in adults[J]. N Engl J Med. 2019;380(15):1442\u20139.","journal-title":"N Engl J Med"},{"issue":"8","key":"3252_CR2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","volume":"7","author":"AV Benjafield","year":"2019","unstructured":"Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis[J]. Lancet Respir Med. 2019;7(8):687\u201398.","journal-title":"Lancet Respir Med"},{"issue":"6","key":"3252_CR3","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jacc.2021.05.048","volume":"78","author":"MR Cowie","year":"2021","unstructured":"Cowie MR, Linz D, Redline S, et al. Sleep disordered breathing and cardiovascular disease: JACC state-of-the-art review[J]. J Am Coll Cardiol. 2021;78(6):608\u201324.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"3252_CR4","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","volume":"144","author":"Y Yeghiazarians","year":"2021","unstructured":"Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association[J]. Circulation. 2021;144(3):e56\u201367.","journal-title":"Circulation"},{"issue":"3","key":"3252_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.5664\/jcsm.27497","volume":"5","author":"LJ Epstein","year":"2009","unstructured":"Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults[J]. J Clin Sleep Med. 2009;5(3):263\u201376.","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"3252_CR6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.5664\/jcsm.7638","volume":"15","author":"SP Patil","year":"2019","unstructured":"Patil SP, Ayappa IA, Caples SM, et al. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment[J]. J Clin Sleep Med. 2019;15(2):301\u201334.","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"3252_CR7","doi-asserted-by":"publisher","first-page":"597","DOI":"10.5664\/jcsm.2172","volume":"8","author":"RB Berry","year":"2012","unstructured":"Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated events. Deliberations of the Sleep Apnea definitions Task Force of the American Academy of Sleep Medicine[J]. J Clin Sleep Med. 2012;8(5):597\u2013619.","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"3252_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11325-009-0298-7","volume":"14","author":"NA Shah","year":"2010","unstructured":"Shah NA, Yaggi HK, Concato J, et al. Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death[J]. Sleep Breath. 2010;14(2):131\u20136.","journal-title":"Sleep Breath"},{"issue":"3","key":"3252_CR9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.resp.2011.03.015","volume":"178","author":"BD Kent","year":"2011","unstructured":"Kent BD, Ryan S, McNicholas WT. Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity[J]. Respir Physiol Neurobiol. 2011;178(3):475\u201381.","journal-title":"Respir Physiol Neurobiol"},{"issue":"17","key":"3252_CR10","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1161\/CIRCULATIONAHA.107.741512","volume":"117","author":"S Jelic","year":"2008","unstructured":"Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea[J]. Circulation. 2008;117(17):2270\u20138.","journal-title":"Circulation"},{"issue":"5","key":"3252_CR11","doi-asserted-by":"publisher","first-page":"e001241","DOI":"10.1161\/JAHA.114.001241","volume":"3","author":"Y Kwon","year":"2014","unstructured":"Kwon Y, Duprez DA, Jacobs DR, et al. Obstructive sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis study[J]. J Am Heart Assoc. 2014;3(5):e001241.","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"3252_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1378\/chest.10-2223","volume":"140","author":"LF Drager","year":"2011","unstructured":"Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: an emerging risk factor for atherosclerosis[J]. Chest. 2011;140(2):534\u201342.","journal-title":"Chest"},{"issue":"4","key":"3252_CR13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1161\/CIRCULATIONAHA.109.901801","volume":"122","author":"DJ Gottlieb","year":"2010","unstructured":"Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study[J]. Circulation. 2010;122(4):352\u201360.","journal-title":"Circulation"},{"issue":"4","key":"3252_CR14","first-page":"321","volume":"101","author":"R Schulz","year":"2006","unstructured":"Schulz R, Grebe M, Eisele HJ, et al. Obstructive sleep apnea-related cardiovascular disease[J]. Med Klin(Munich). 2006;101(4):321\u20137.","journal-title":"Med Klin(Munich)"},{"key":"3252_CR15","first-page":"299","volume":"53","author":"N Dursunoglu","year":"2005","unstructured":"Dursunoglu N, Dursunoglu D. Obstructive sleep apnea syndrome, endothelial dysfunction and coronary atherosclerosis. Tuberk Toraks. 2005;53:299\u2013306.","journal-title":"Tuberk Toraks"},{"issue":"5","key":"3252_CR16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1161\/01.ATV.0000160548.78317.29","volume":"25","author":"SJ Zieman","year":"2005","unstructured":"Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932\u201343.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"3252_CR17","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/HCO.0000000000000179","volume":"30","author":"I Ikonomidis","year":"2015","unstructured":"Ikonomidis I, Makavos G, Lekakis J. Arterial stiffness and coronary artery disease. Curr Opin Cardiol. 2015;30(4):422\u201331.","journal-title":"Curr Opin Cardiol"},{"issue":"5","key":"3252_CR18","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1161\/CIRCULATIONAHA.105.555235","volume":"113","author":"FU Mattace-Raso","year":"2006","unstructured":"Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113(5):657\u201363.","journal-title":"Circulation"},{"issue":"3","key":"3252_CR19","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1755-5922.2008.00051.x","volume":"26","author":"X Wang","year":"2008","unstructured":"Wang X, Keith JC Jr, Struthers AD, Feuerstein GZ. Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk. Cardiovasc Ther. 2008;26(3):214\u201323.","journal-title":"Cardiovasc Ther"},{"key":"3252_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature10146","volume":"473","author":"P Libby","year":"2011","unstructured":"Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis [J]. Nature. 2011;473:317\u201325.","journal-title":"Nature"},{"key":"3252_CR21","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1161\/01.CIR.101.15.1767","volume":"101","author":"PM Ridker","year":"2000","unstructured":"Ridker PM, Rifai N, Stampfer MJ, et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men [J]. Circulation. 2000;101:1767\u201372.","journal-title":"Circulation"},{"key":"3252_CR22","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/01.CIR.0000158479.58589.0A","volume":"111","author":"W Maier","year":"2005","unstructured":"Maier W, Altwegg LA, Corti R, et al. Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein [J]. Circulation. 2005;111:1355\u201361.","journal-title":"Circulation"},{"issue":"1","key":"3252_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.smrv.2012.01.002","volume":"17","author":"I-T Vlachantoni","year":"2013","unstructured":"Vlachantoni I-T, Dikaiakou E, Antonopoulos CN, et al. Effects of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea in arterial stiffness: a meta-analysis [J]. Sleep Med Rev. 2013;17(1):19\u201328.","journal-title":"Sleep Med Rev"},{"issue":"4","key":"3252_CR24","doi-asserted-by":"publisher","first-page":"e12990","DOI":"10.1111\/jsr.12990","volume":"29","author":"CRL Cardoso","year":"2020","unstructured":"Cardoso CRL, Roderjan CN, Cavalcanti AH, et al. Effects of continuous positive airway pressure treatment on aortic stiffness in patients with resistant hypertension and obstructive sleep apnea: a randomized controlled trial [J]. J Sleep Res. 2020;29(4):e12990.","journal-title":"J Sleep Res"},{"issue":"8","key":"3252_CR25","doi-asserted-by":"publisher","first-page":"e0236667","DOI":"10.1371\/journal.pone.0236667","volume":"15","author":"LM Galerneau","year":"2020","unstructured":"Galerneau LM, Bailly S, Borel JC, et al. Long-term variations of arterial stiffness in patients with obesity and obstructive sleep apnea treated with continuous positive airway pressure [J]. PLoS ONE. 2020;15(8):e0236667.","journal-title":"PLoS ONE"},{"key":"3252_CR26","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1001\/jama.290.14.1906","volume":"290","author":"AS Shamsuzzaman","year":"2003","unstructured":"Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003;290:1906\u201314.","journal-title":"JAMA"},{"key":"3252_CR27","first-page":"e40","volume":"107","author":"T Shinji","year":"2003","unstructured":"Shinji T. Increased C-reactive protein and increased plasma interleukin- 6 may synergistically affect the progression of coronary atherosclerosis in obstructive sleep apnea syndrome. Circulation. 2003;107:e40.","journal-title":"Circulation"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03252-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-03252-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03252-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T01:04:20Z","timestamp":1736557460000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-03252-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3252"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-03252-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5057303\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]},"assertion":[{"value":"9 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethical Committee of Shanghai east hospital affiliated to Tongji University. Written informed consent was obtained from all individual participants prior to data collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consents were obtained from the patients for publication of this study. The copy of the written consents was available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}