{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:25:07Z","timestamp":1772166307589,"version":"3.50.1"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tianjin Medical Key Specialty Construction Project","award":["TJYXZDXK-018A"],"award-info":[{"award-number":["TJYXZDXK-018A"]}]},{"name":"Tianjin Metrology Science and Technology Project","award":["2024TJMT001"],"award-info":[{"award-number":["2024TJMT001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paragangliomas are rare neuroendocrine tumors predominantly located within the adrenal gland. Extra-adrenal paragangliomas, particularly those in the anterosuperior mediastinum, are exceedingly rare and pose significant diagnostic and therapeutic challenges due to their complex anatomical location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 42-year-old woman was found to have an anterosuperior mediastinal mass during a routine health screening. Enhanced chest computed tomography (CT) revealed an ovoid, low-density mass intricately associated with major vascular structures including the superior vena cava, brachiocephalic trunk, left common carotid artery, aortic arch, right anonymous vein, and right subclavian artery. Despite significant intraoperative blood loss of 2000\u00a0ml, the mass was successfully excised with meticulous surgical technique and effective hemostasis. Histopathological examination showed a classic Zellballen pattern with chief cells and sustentacular cells embedded in a vascular-rich stroma. Immunohistochemistry confirmed the tumor\u2019s chromaffin nature, with chief cells testing positive for CD56, Synaptophysin, and Chromogranin A, and sustentacular cells positive for S100 protein, consistent with a diagnosis of paraganglioma. The patient\u2019s postoperative recovery was uneventful, and she was discharged one week after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the essential role of comprehensive preoperative imaging and the necessity for interdisciplinary surgical expertise in managing complex mediastinal paragangliomas. Advanced surgical techniques and careful intraoperative management are paramount to achieving successful outcomes. Appropriate imaging modalities and auxiliary laboratory tests are crucial for early detection of recurrences in these rare tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-024-03283-9","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:31:15Z","timestamp":1744007475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anterosuperior mediastinal paraganglioma in a 42-Year-old woman: a diagnostic and therapeutic challenge\u2014a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenkang","family":"Zong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xike","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"3283_CR1","doi-asserted-by":"publisher","first-page":"107296","DOI":"10.1016\/j.rmed.2023.107296","volume":"216","author":"AN Kanj","year":"2023","unstructured":"Kanj AN, Young WF, Ryu JH. Mediastinal Paraganglioma: a retrospective analysis of 51 cases. Respir Med. 2023;216:107296. https:\/\/doi.org\/10.1016\/j.rmed.2023.107296.","journal-title":"Respir Med"},{"issue":"3","key":"3283_CR2","doi-asserted-by":"publisher","first-page":"S375","DOI":"10.1016\/j.jtho.2021.01.605","volume":"16","author":"M Shibata","year":"2021","unstructured":"Shibata M, Saito M, Kobayashi J. P22.08 paraganglioma of the Anterior Mediastinum. J Thorac Oncol. 2021;16(3):S375. https:\/\/doi.org\/10.1016\/j.jtho.2021.01.605.","journal-title":"J Thorac Oncol"},{"issue":"3","key":"3283_CR3","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.athoracsur.2008.04.105","volume":"86","author":"ML Brown","year":"2008","unstructured":"Brown ML, Zayas GE, Abel MD, Young WF, Schaff HV. Mediastinal paragangliomas: the Mayo Clinic Experience. Ann Thorac Surg. 2008;86(3):946\u201351. https:\/\/doi.org\/10.1016\/j.athoracsur.2008.04.105.","journal-title":"Ann Thorac Surg"},{"issue":"12","key":"3283_CR4","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","volume":"31","author":"G Rindi","year":"2018","unstructured":"Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathology: Official J United States Can Acad Pathol Inc. 2018;31(12):1770\u201386. https:\/\/doi.org\/10.1038\/s41379-018-0110-y.","journal-title":"Mod Pathology: Official J United States Can Acad Pathol Inc"},{"issue":"3","key":"3283_CR5","doi-asserted-by":"publisher","first-page":"e210063","DOI":"10.1148\/ryct.2021210063","volume":"3","author":"S Landreth","year":"2021","unstructured":"Landreth S, Bhamidipati C, Muralidaran A, Sauer D, Goldner B, Fuss C. Mediastinal Mass: an unusual location for a Paraganglioma. Radiology: Cardiothorac Imaging. 2021;3(3):e210063. https:\/\/doi.org\/10.1148\/ryct.2021210063.","journal-title":"Radiology: Cardiothorac Imaging"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-024-03283-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-024-03283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:31:18Z","timestamp":1744007478000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-024-03283-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3283"],"URL":"https:\/\/doi.org\/10.1186\/s13019-024-03283-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5216731\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"7 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in this study were in accordance with the ethical standards of the institutional and national research committee(s) and with the Declaration of Helsinki (as revised in 2013). Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"182"}}