{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:58:42Z","timestamp":1791550722504,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":52,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100022831","name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","doi-asserted-by":"publisher","award":["2022\/109"],"award-info":[{"award-number":["2022\/109"]}],"id":[{"id":"10.13039\/100022831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"DOI":"10.1186\/s13019-025-03751-w","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:49:05Z","timestamp":1764334145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vasculoprotective role of del Nido cardioplegia in open-heart surgery via modulation of E-Selectin, Endocan, and TNF-alpha coronary sinus blood samples"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-371X","authenticated-orcid":false,"given":"Fatih","family":"K\u0131z\u0131lyel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-7131","authenticated-orcid":false,"given":"Tamer","family":"Cebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-0082","authenticated-orcid":false,"given":"Mehmet","family":"Rum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-0773","authenticated-orcid":false,"given":"K\u00fcbra","family":"Bozali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-3083","authenticated-orcid":false,"given":"\u015eeydanur","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-6876","authenticated-orcid":false,"given":"Mehmet","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-7654","authenticated-orcid":false,"given":"Tamer","family":"Kehlibar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-0154","authenticated-orcid":false,"given":"B\u00fclend","family":"Ketenci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"3751_CR1","doi-asserted-by":"publisher","first-page":"1287724","DOI":"10.3389\/fcvm.2023.1287724","volume":"10","author":"C Bello","year":"2023","unstructured":"Bello C, Filipovic MG, Huber M, Flannery S, Kobel B, Fischer R, et al. Discovery of plasma proteome markers associated with clinical outcome and immunological stress after cardiac surgery. Front Cardiovasc Med. 2023;10:1287724. https:\/\/doi.org\/10.3389\/fcvm.2023.1287724.","journal-title":"Front Cardiovasc Med"},{"key":"3751_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1051\/ject\/201850083","volume":"50","author":"JM Ali","year":"2018","unstructured":"Ali JM, Miles LF, Abu-Omar Y, Galhardo C, Falter F. Global cardioplegia practices: results from the global cardiopulmonary bypass survey. J Extra Corpor Technol. 2018;50:83\u201393. https:\/\/doi.org\/10.1051\/ject\/201850083.","journal-title":"J Extra Corpor Technol"},{"key":"3751_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1051\/ject\/201244098","volume":"44","author":"GS Matte","year":"2012","unstructured":"Matte GS, del Nido PJ. History and use of Del Nido cardioplegia solution at Boston children\u2019s hospital. J Extra Corpor Technol. 2012;44:98\u2013103. https:\/\/doi.org\/10.1051\/ject\/201244098.","journal-title":"J Extra Corpor Technol"},{"key":"3751_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.jtcvs.2017.09.146","volume":"155","author":"N Ad","year":"2018","unstructured":"Ad N, Holmes SD, Massimiano PS, Rongione AJ, Fornaresio LM, Fitzgerald D. The use of Del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial. J Thorac Cardiovasc Surg. 2018;155:1011\u20138. https:\/\/doi.org\/10.1016\/j.jtcvs.2017.09.146.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3751_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.21037\/jtd-21-1965","volume":"14","author":"X Lin","year":"2022","unstructured":"Lin X, Jiang Y, Zhu P, Peng Q, Meng W, Zheng S. The application of Del Nido cardioplegia for myocardial protection in adult coronary artery bypass grafting: a cohort study. J Thorac Dis. 2022;14:177\u201384. https:\/\/doi.org\/10.21037\/jtd-21-1965.","journal-title":"J Thorac Dis"},{"key":"3751_CR6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1053\/j.jvca.2023.12.017","volume":"38","author":"E Viikinkoski","year":"2024","unstructured":"Viikinkoski E, Aittokallio J, Lehto J, Ollila H, Relander A, Vasankari T, et al. Prolonged systemic inflammatory response syndrome after cardiac surgery. J Cardiothorac Vasc Anesth. 2024;38:709\u201316. https:\/\/doi.org\/10.1053\/j.jvca.2023.12.017.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"3751_CR7","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.1016\/j.jtcvs.2021.06.029","volume":"164","author":"Y Song","year":"2022","unstructured":"Song Y, Xing H, He Y, Zhang Z, Shi G, Wu S, et al. Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia\/reoxygenation. J Thorac Cardiovasc Surg. 2022;164:e207\u201326. https:\/\/doi.org\/10.1016\/j.jtcvs.2021.06.029.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3751_CR8","doi-asserted-by":"publisher","first-page":"19249","DOI":"10.1038\/s41598-019-55863-8","volume":"9","author":"C Weber","year":"2019","unstructured":"Weber C, Jenke A, Chobanova V, Yazdanyar M, Chekhoeva A, Eghbalzadeh K, et al. Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass. Sci Rep. 2019;9:19249. https:\/\/doi.org\/10.1038\/s41598-019-55863-8.","journal-title":"Sci Rep"},{"key":"3751_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8295054","volume":"2019","author":"R Bauersachs","year":"2019","unstructured":"Bauersachs R, Zeymer U, Bri\u00e8re J-B, Marre C, Bowrin K, Huelsebeck M. Burden of coronary artery disease and peripheral artery disease: a literature review. Cardiovasc Ther. 2019;2019:8295054. https:\/\/doi.org\/10.1155\/2019\/8295054.","journal-title":"Cardiovasc Ther"},{"key":"3751_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.amjmed.2016.10.005","volume":"130","author":"J Joseph","year":"2017","unstructured":"Joseph J, Naqvi SY, Giri J, Goldberg S. Aortic stenosis: pathophysiology, diagnosis, and therapy. Am J Med. 2017;130:253\u201363. https:\/\/doi.org\/10.1016\/j.amjmed.2016.10.005.","journal-title":"Am J Med"},{"key":"3751_CR11","doi-asserted-by":"publisher","unstructured":"Tahmazli J, Turgut \u015e, Cebe T, K\u0131z\u0131lyel F, Atasever E, \u00dc\u011f\u00fcden A, et al. Importance of systemic redox homeostasis biomarkers and transcription factors in patients undergoing open-heart surgery with cardiopulmonary bypass. Surg Today. 2025;55(9):1320\u201334.  https:\/\/doi.org\/10.1007\/s00595-025-03026-w.","DOI":"10.1007\/s00595-025-03026-w"},{"key":"3751_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.798699","author":"J Chen","year":"2022","unstructured":"Chen J, Jiang L, Yu X-H, Hu M, Zhang Y-K, Liu X, et al. Endocan: a key player of cardiovascular disease. Front Cardiovasc Med. 2022. https:\/\/doi.org\/10.3389\/fcvm.2021.798699.","journal-title":"Front Cardiovasc Med"},{"key":"3751_CR13","doi-asserted-by":"publisher","first-page":"1401399","DOI":"10.3389\/fimmu.2024.1401399","volume":"15","author":"J Zhang","year":"2024","unstructured":"Zhang J, Huang S, Zhu Z, Gatt A, Liu J. E-selectin in vascular pathophysiology. Front Immunol. 2024;15:1401399. https:\/\/doi.org\/10.3389\/fimmu.2024.1401399.","journal-title":"Front Immunol"},{"key":"3751_CR14","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.4049\/jimmunol.2300043","volume":"211","author":"J Zhang","year":"2023","unstructured":"Zhang J, Zhang S, Xu S, Zhu Z, Li J, Wang Z, et al. Oxidative stress induces E-selectin expression through repression of endothelial transcription factor ERG. J Immunol. 2023;211:1835\u201343. https:\/\/doi.org\/10.4049\/jimmunol.2300043.","journal-title":"J Immunol"},{"key":"3751_CR15","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.hrthm.2014.07.007","volume":"11","author":"QA Truong","year":"2014","unstructured":"Truong QA, Januzzi JL, Szymonifka J, Thai W, Wai B, Lavender Z, et al. Coronary sinus biomarker sampling compared to peripheral venous blood for predicting outcomes in patients with severe heart failure undergoing cardiac resynchronization therapy: the BIOCRT study. Heart Rhythm. 2014;11:2167\u201375. https:\/\/doi.org\/10.1016\/j.hrthm.2014.07.007.","journal-title":"Heart Rhythm"},{"issue":"2","key":"3751_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/bf03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A. G*power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175\u201391. https:\/\/doi.org\/10.3758\/bf03193146.","journal-title":"Behav Res Methods"},{"key":"3751_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8742075","volume":"2019","author":"A Federico","year":"2019","unstructured":"Federico A, Dallio M, Masarone M, Gravina AG, Di Sarno R, Tuccillo C, et al. Evaluation of the effect derived from silybin with vitamin D and vitamin E administration on clinical, metabolic, endothelial dysfunction, oxidative stress parameters, and serological worsening markers in nonalcoholic fatty liver disease patients. Oxid Med Cell Longev. 2019;2019:8742075. https:\/\/doi.org\/10.1155\/2019\/8742075.","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"3751_CR18","doi-asserted-by":"publisher","first-page":"658","DOI":"10.4330\/wjc.v7.i10.658","volume":"7","author":"YD Durandy","year":"2015","unstructured":"Durandy YD. Is there a rationale for short cardioplegia re-dosing intervals? World J Cardiol. 2015;7(10):658\u201364. https:\/\/doi.org\/10.4330\/wjc.v7.i10.658.","journal-title":"World J Cardiol"},{"key":"3751_CR19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5114\/kitp.2018.76477","volume":"15","author":"K Sanetra","year":"2018","unstructured":"Sanetra K, Pawlak I, Cisowski M. Del Nido cardioplegia - what is the current evidence? Kardiochir Torakochirurgia Pol. 2018;15:114\u20138. https:\/\/doi.org\/10.5114\/kitp.2018.76477.","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"3751_CR20","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1177\/02676591231216315","volume":"39","author":"S Gunaydin","year":"2024","unstructured":"Gunaydin S, McCusker K, Nicotra W. Redosing of long acting cardioplegic solutions in adult cardiac surgery: a comparative study. Perfusion. 2024;39:1685\u201391. https:\/\/doi.org\/10.1177\/02676591231216315.","journal-title":"Perfusion"},{"key":"3751_CR21","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.jtcvs.2021.11.053","volume":"165","author":"SD Waterford","year":"2023","unstructured":"Waterford SD, Ad N. Del Nido cardioplegia: questions and (some) answers. J Thorac Cardiovasc Surg. 2023;165:1104\u20138. https:\/\/doi.org\/10.1016\/j.jtcvs.2021.11.053.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"3751_CR22","doi-asserted-by":"publisher","first-page":"e20240315","DOI":"10.21470\/1678-9741-2024-0315","volume":"40","author":"T Cebe","year":"2025","unstructured":"Cebe T, Turgut S, K\u0131z\u0131lyel F, et al. Redox signaling biomarker and transcription factor assessments are important to evaluate myocardial protection status through different cardioplegias. Braz J Cardiovasc Surg. 2025;40(5):e20240315. https:\/\/doi.org\/10.21470\/1678-9741-2024-0315. Published 2025 Aug 7.","journal-title":"Braz J Cardiovasc Surg"},{"key":"3751_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1021\/pr800545q","volume":"8","author":"MK Tuck","year":"2009","unstructured":"Tuck MK, Chan DW, Chia D, Godwin AK, Grizzle WE, Krueger KE, et al. Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group. J Proteome Res. 2009;8:113\u20137. https:\/\/doi.org\/10.1021\/pr800545q.","journal-title":"J Proteome Res"},{"key":"3751_CR24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1177\/1076029615618024","volume":"23","author":"H Kundi","year":"2017","unstructured":"Kundi H, Gok M, Kiziltunc E, Topcuoglu C, Cetin M, Cicekcioglu H, et al. The relationship between serum endocan levels with the presence of slow coronary flow: a cross-sectional study. Clin Appl Thromb Hemost. 2017;23:472\u20137. https:\/\/doi.org\/10.1177\/1076029615618024.","journal-title":"Clin Appl Thromb Hemost"},{"key":"3751_CR25","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120965752","volume":"8","author":"MN Amin","year":"2020","unstructured":"Amin MN, Siddiqui SA, Ibrahim M, Hakim ML, Ahammed MS, Kabir A, et al. Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer. SAGE Open Med. 2020;8:2050312120965752. https:\/\/doi.org\/10.1177\/2050312120965752.","journal-title":"SAGE Open Med"},{"key":"3751_CR26","doi-asserted-by":"publisher","first-page":"156261","DOI":"10.1016\/j.cyto.2023.156261","volume":"169","author":"H Haybar","year":"2023","unstructured":"Haybar H, Bandar B, Torfi E, Mohebbi A, Saki N. Cytokines and their role in cardiovascular diseases. Cytokine. 2023;169:156261. https:\/\/doi.org\/10.1016\/j.cyto.2023.156261.","journal-title":"Cytokine"},{"key":"3751_CR27","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1080\/10641963.2022.2036993","volume":"44","author":"A Belce","year":"2022","unstructured":"Belce A, Ozkan BN, Dumlu FS, Sisman BH, Guler EM. Evaluation of oxidative stress and inflammatory biomarkers pre and post-treatment in new diagnosed atherosclerotic patients. Clin Exp Hypertens. 2022;44:320\u20135. https:\/\/doi.org\/10.1080\/10641963.2022.2036993.","journal-title":"Clin Exp Hypertens"},{"key":"3751_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3315951","volume":"2021","author":"P Vukicevic","year":"2021","unstructured":"Vukicevic P, Klisic A, Neskovic V, Babic L, Mikic A, Bogavac-Stanojevic N, et al. Oxidative stress in patients before and after on-pump and off-pump coronary artery bypass grafting: relationship with Syntax score. Oxid Med Cell Longev. 2021;2021:3315951. https:\/\/doi.org\/10.1155\/2021\/3315951.","journal-title":"Oxid Med Cell Longev"},{"key":"3751_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mrgentox.2005.01.014","volume":"583","author":"M Harma","year":"2005","unstructured":"Harma M, Harma M, Kocyigit A, Erel O. Increased DNA damage in patients with complete hydatidiform mole. Mutat Res. 2005;583:49\u201354. https:\/\/doi.org\/10.1016\/j.mrgentox.2005.01.014.","journal-title":"Mutat Res"},{"key":"3751_CR30","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0140-6736(13)60108-7","volume":"381","author":"V Farooq","year":"2013","unstructured":"Farooq V, van Klaveren D, Steyerberg EW, Meliga E, Vergouwe Y, Chieffo A, et al. Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II. Lancet. 2013;381:639\u201350. https:\/\/doi.org\/10.1016\/S0140-6736(13)60108-7.","journal-title":"Lancet"},{"key":"3751_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.4103\/tjem.tjem_182_23","volume":"23","author":"\u015eK \u00c7orbac\u0131o\u011flu","year":"2023","unstructured":"\u00c7orbac\u0131o\u011flu \u015eK, Aksel G. Receiver operating characteristic curve analysis in diagnostic accuracy studies. Turk J Emerg Med. 2023;23:195\u20138. https:\/\/doi.org\/10.4103\/tjem.tjem_182_23.","journal-title":"Turk J Emerg Med"},{"key":"3751_CR32","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/02676591211031095","volume":"38","author":"K Zhai","year":"2023","unstructured":"Zhai K, Cheng X, Zhang P, Wei S, Huang J, Wu X, et al. Del nido cardioplegia for myocardial protection in adult cardiac surgery: a systematic review and update meta-analysis. Perfusion. 2023;38:6\u201317. https:\/\/doi.org\/10.1177\/02676591211031095.","journal-title":"Perfusion"},{"key":"3751_CR33","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.hlc.2020.10.016","volume":"30","author":"S Misra","year":"2021","unstructured":"Misra S, Srinivasan A, Jena SS, Bellapukonda S. Myocardial protection in adult cardiac surgery with Del nido versus blood cardioplegia: a systematic review and meta-analysis. Heart Lung Circ. 2021;30:642\u201355. https:\/\/doi.org\/10.1016\/j.hlc.2020.10.016.","journal-title":"Heart Lung Circ"},{"key":"3751_CR34","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/bs.apha.2025.02.011","volume":"104","author":"T Cebe","year":"2025","unstructured":"Cebe T, K\u0131z\u0131lyel F. Risk of senescence, polypharmacy, and their outcomes in elderly cardiovascular disease patients. Adv Pharmacol. 2025;104:351\u201392. https:\/\/doi.org\/10.1016\/bs.apha.2025.02.011.","journal-title":"Adv Pharmacol"},{"key":"3751_CR35","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/biom15010022","volume":"15","author":"M Rac","year":"2024","unstructured":"Rac M, Rac M, Krzystolik A, Safranow K, Chlubek D, Dziedziejko V. Evaluation of plasma E-selectin concentration as a risk marker for atherosclerotic vascular damage in patients with early CAD. Biomolecules. 2024;15:22. https:\/\/doi.org\/10.3390\/biom15010022.","journal-title":"Biomolecules"},{"key":"3751_CR36","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s13019-024-02846-0","volume":"19","author":"C Li","year":"2024","unstructured":"Li C, Xiang H, Yang H, Liu W, Lan W, Luo C, et al. Del nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials. J Cardiothorac Surg. 2024;19:356. https:\/\/doi.org\/10.1186\/s13019-024-02846-0.","journal-title":"J Cardiothorac Surg"},{"key":"3751_CR37","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13019-024-02683-1","volume":"19","author":"SK Garg","year":"2024","unstructured":"Garg SK, Rawat RS, Saad DA, Omar I. Del nido cardioplegia in adults: a retrospective observational study in comparison to modified St. Thomas cardioplegia in cardiac surgery. J Cardiothorac Surg. 2024;19:266. https:\/\/doi.org\/10.1186\/s13019-024-02683-1.","journal-title":"J Cardiothorac Surg"},{"key":"3751_CR38","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1177\/02676591241312380","volume":"40","author":"LN Consoli","year":"2025","unstructured":"Consoli LN, Koziakas IG, Kanakis M. Del nido versus conventional blood cardioplegia in tetralogy of fallot repair: a systematic review and meta-analysis of randomized controlled trials. Perfusion. 2025;40:1535\u201345. https:\/\/doi.org\/10.1177\/02676591241312380.","journal-title":"Perfusion"},{"key":"3751_CR39","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/metabo13050640","volume":"13","author":"A Klisic","year":"2023","unstructured":"Klisic A, Patoulias D. The role of endocan in cardiometabolic disorders. Metabolites. 2023;13:640. https:\/\/doi.org\/10.3390\/metabo13050640.","journal-title":"Metabolites"},{"key":"3751_CR40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3109\/08037051.2014.972816","volume":"24","author":"T Cel\u0131k","year":"2015","unstructured":"Cel\u0131k T, Balta S, Karaman M, Ahmet Ay S, Dem\u0131rkol S, Ozturk C, et al. Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: comparative effects of amlodipine and valsartan. Blood Press. 2015;24:55\u201360. https:\/\/doi.org\/10.3109\/08037051.2014.972816.","journal-title":"Blood Press"},{"key":"3751_CR41","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.arcmed.2019.08.012","volume":"50","author":"E Zolali","year":"2019","unstructured":"Zolali E, Rezabakhsh A, Nabat E, Jaberi H, Rahbarghazi R, Garjani A. Metformin effect on endocan biogenesis in human endothelial cells under diabetic condition. Arch Med Res. 2019;50:304\u201314. https:\/\/doi.org\/10.1016\/j.arcmed.2019.08.012.","journal-title":"Arch Med Res"},{"key":"3751_CR42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.34172\/PS.2020.2","volume":"26","author":"E Zolali","year":"2020","unstructured":"Zolali E, Shayesteh S, Rahbarghazi R, Vaez H, Heidari HR, Garjani A. Metformin had potential to increase endocan levels in STZ-induced diabetic mice. Pharm Sci. 2020;26:133\u201341. https:\/\/doi.org\/10.34172\/PS.2020.2.","journal-title":"Pharm Sci"},{"key":"3751_CR43","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.accpm.2018.02.013","volume":"37","author":"A Bougl\u00e9","year":"2018","unstructured":"Bougl\u00e9 A, Allain P-A, Favard S, Ait Hamou N, Carillion A, Leprince P, et al. Postoperative serum levels of Endocan are associated with the duration of norepinephrine support after coronary artery bypass surgery. Anaesthesia Critical Care & Pain Medicine. 2018;37:565\u201370. https:\/\/doi.org\/10.1016\/j.accpm.2018.02.013.","journal-title":"Anaesthesia Critical Care & Pain Medicine"},{"key":"3751_CR44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.niox.2021.09.006","volume":"117","author":"SK Kumar","year":"2021","unstructured":"Kumar SK, Mani KP. Endocan alters nitric oxide production in endothelial cells by targeting AKT\/eNOS and NFkB\/iNOS signaling. Nitric Oxide. 2021;117:26\u201333. https:\/\/doi.org\/10.1016\/j.niox.2021.09.006.","journal-title":"Nitric Oxide"},{"key":"3751_CR45","doi-asserted-by":"publisher","unstructured":"Cebe T, K\u0131z\u0131lyel F, Ketenci B. Redox signaling in age-related vascular disease and wound healing. In Advances in Biogerontology. 2025;3:153\u2013188). https:\/\/doi.org\/10.1016\/bs.abger.2024.05.011","DOI":"10.1016\/bs.abger.2024.05.011"},{"key":"3751_CR46","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1160\/TH02-09-0083","volume":"90","author":"V Rold\u00e1n","year":"2003","unstructured":"Rold\u00e1n V, Mar\u00edn F, Lip G, Blann A. Soluble E-selectin in cardiovascular disease and its risk factors. Thromb Haemost. 2003;90:1007\u201320. https:\/\/doi.org\/10.1160\/TH02-09-0083.","journal-title":"Thromb Haemost"},{"key":"3751_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/biology12030347","volume":"12","author":"A Kapelouzou","year":"2023","unstructured":"Kapelouzou A, Geronikolou S, Lidoriki I, Kontogiannis C, Kaklamanis L, Tsourelis L, et al. Tissue and serum biomarkers in degenerative aortic stenosis-insights into pathogenesis, prevention and therapy. Biology (Basel). 2023;12:347. https:\/\/doi.org\/10.3390\/biology12030347.","journal-title":"Biology (Basel)"},{"key":"3751_CR48","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1177\/02676591221144166","volume":"39","author":"K Sanetra","year":"2024","unstructured":"Sanetra K, Gerber W, Domaradzki W, Mazur M, Synak M, Kubaszewska M, et al. Use of del Nido cardioplegia in acute coronary syndrome cases with decreased ejection fraction. Perfusion. 2024;39:353\u201361. https:\/\/doi.org\/10.1177\/02676591221144166.","journal-title":"Perfusion"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-025-03751-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-025-03751-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-025-03751-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:17:01Z","timestamp":1768843021000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13019-025-03751-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3751"],"URL":"https:\/\/doi.org\/10.1186\/s13019-025-03751-w","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"19 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30"}}