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The use and rationale for using an alternate bone hemostat were also recorded in cases where alternate bone hemostats were used. Adverse events that started from the time of the index procedure until 30 days postoperatively were also recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Intraoperative bone bleeding was successfully controlled with the application of Ostene in 87 of 89 patients (97.8%) who were eligible for effectiveness analyses. Intraoperative rebleeds were observed in 23 of 90 patients (25.6%) 238.1\u2009\u00b1\u200961.7\u00a0min after hemostasis of the original bleed was achieved. Final hemostasis was achieved by reapplying Ostene in 21 patients and alternate bone hemostats in 2 of the 23 patients. None of the patients in the study had postoperative bone bleeding within 24\u00a0h of surgery. Few AEs occurred in the study cohort, all unrelated to Ostene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ostene proved to be effective bone hemostat for the control of intraoperative bone bleeding in cardiac surgical patients undergoing median sternotomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-026-04357-6","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:54:39Z","timestamp":1781070879000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a water-soluble alkylene oxide copolymer based bone hemostat in cardiac surgery: a prospective, multicenter, single-arm study"],"prefix":"10.1186","volume":"21","author":[{"given":"Kentaro","family":"Yamane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad F.","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Micallef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Parreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia C. 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Kentaro Yamane is a Principal Investigator of the study sponsored by Baxter.","order":1,"name":"Ethics","label":"Disclosure","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board (IRB) at Penn State Office for Research Protections approved IRB #65 on 25 February 2022, that at Washington University in St. Louis approved IRB #202204146 on 06 March 2022, and that at The Christ Hospital Health Network approved IRB #21\u2009\u2212\u200909 on 29 March 2021.","order":2,"name":"Ethics","label":"Institutional Review Boards","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The applicable informed consent form was obtained from each patient or the patient\u2019s legal representative before any study data was collected (outside routine data).","order":3,"name":"Ethics","label":"Consent statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Shengchun Wang, Lara Micallef, Rhea Parreno, and Flavia Morone Pinto are employees of Baxter Healthcare Corporation. Kentaro Yamane is a Principal Investigator of the study sponsored by Baxter. This study was funded by Baxter Healthcare Corporation, the manufacturer of Ostene Bone Hemostat (Water-Soluble Alkylene Oxide Copolymer).","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"588"}}