{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:09:21Z","timestamp":1789088961730,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"DOI":"10.1186\/s13019-026-04486-y","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:27:24Z","timestamp":1782466044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors and prognosis of postoperative hepatic dysfunction after Stanford type A aortic dissection repair: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"21","author":[{"given":"Hongtao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronecca","family":"Arjune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aini","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"17","key":"4486_CR1","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","volume":"137","author":"A Evangelista","year":"2018","unstructured":"Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, et al. Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research. Circulation. 2018;137(17):1846\u201360.","journal-title":"Circulation"},{"issue":"4","key":"4486_CR2","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.suc.2009.05.003","volume":"89","author":"MR Moon","year":"2009","unstructured":"Moon MR. Approach to the treatment of aortic dissection. Surg Clin North Am. 2009;89(4):869\u201393. ix.","journal-title":"Surg Clin North Am"},{"issue":"1","key":"4486_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.athoracsur.2024.01.021","volume":"118","author":"M Czerny","year":"2024","unstructured":"Czerny M, Grabenw\u00f6ger M, Berger T, Aboyans V, Della Corte A, Chen EP, Desai ND, Dumfarth J, Elefteriades JA, Etz CD, et al. EACTS\/STS Guidelines for Diagnosing and Treating Acute and Chronic Syndromes of the Aortic Organ. Ann Thorac Surg. 2024;118(1):5\u2013115.","journal-title":"Ann Thorac Surg"},{"key":"4486_CR4","doi-asserted-by":"publisher","first-page":"100131","DOI":"10.1016\/j.lanepe.2021.100131","volume":"7","author":"U Benedetto","year":"2021","unstructured":"Benedetto U, Sinha S, Dimagli A, Cooper G, Mariscalco G, Uppal R, Moorjani N, Krasopoulos G, Kaura A, Field M, et al. Decade-long trends in surgery for acute Type A aortic dissection in England: A retrospective cohort study. Lancet Reg Health Eur. 2021;7:100131.","journal-title":"Lancet Reg Health Eur"},{"issue":"4","key":"4486_CR5","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.athoracsur.2022.10.037","volume":"115","author":"GJ Arnaoutakis","year":"2023","unstructured":"Arnaoutakis GJ, Ogami T, Patel HJ, Pai CW, Woznicki EM, Brinster DR, Leshnower BG, Serna-Gallegos D, Bekeredjian R, Sundt TM, et al. Acute Kidney Injury in Patients Undergoing Surgery for Type A Acute Aortic Dissection. Ann Thorac Surg. 2023;115(4):879\u201385.","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"4486_CR6","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s00268-021-06375-y","volume":"46","author":"CY Lin","year":"2022","unstructured":"Lin CY, Lee CY, Lee HF, Wu MY, Tseng CN, Tsai FC, Lin YH. Postoperative Stroke After Type A Aortic Dissection Repair: Hemorrhage Versus Ischemia. World J Surg. 2022;46(3):690\u2013700.","journal-title":"World J Surg"},{"issue":"22","key":"4486_CR7","doi-asserted-by":"publisher","first-page":"e027178","DOI":"10.1161\/JAHA.122.027178","volume":"11","author":"JY Hsu","year":"2022","unstructured":"Hsu JY, Liu PP, Liu AB, Huang HK, Loh CH. Long-Term Risks of Stroke in Patients With Type A Aortic Dissection: A Nationwide Cohort Study. J Am Heart Assoc. 2022;11(22):e027178.","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"4486_CR8","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.athoracsur.2020.07.019","volume":"111","author":"D Helgason","year":"2021","unstructured":"Helgason D, Helgadottir S, Ahlsson A, Gunn J, Hjortdal V, Hansson EC, Jeppsson A, Mennander A, Nozohoor S, Zindovic I, et al. Acute Kidney Injury After Acute Repair of Type A Aortic Dissection. Ann Thorac Surg. 2021;111(4):1292\u20138.","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"4486_CR9","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/ejcts\/ezx465","volume":"53","author":"J Dumfarth","year":"2018","unstructured":"Dumfarth J, Kofler M, Stastny L, Plaikner M, Krapf C, Semsroth S, Grimm M. Stroke after emergent surgery for acute type A aortic dissection: predictors, outcome and neurological recovery. Eur J Cardiothorac Surg. 2018;53(5):1013\u201320.","journal-title":"Eur J Cardiothorac Surg"},{"key":"4486_CR10","doi-asserted-by":"crossref","unstructured":"Han X, Wang W, Gu T, Shi E: Development and validation of a predictive model for postoperative hepatic dysfunction in Stanford type A aortic dissection. Scientific Reports 2025, 15(1):22126.","DOI":"10.1038\/s41598-025-06024-7"},{"issue":"5","key":"4486_CR11","doi-asserted-by":"publisher","first-page":"E459","DOI":"10.59958\/hsf.7199","volume":"27","author":"W Yu","year":"2024","unstructured":"Yu W, Liang Y, Yu J, Gao J, Li W, Tian C, Zhong X, Li P, Liu Z, Xiong J. Risk Factors of Hyperbilirubinemia after Acute Type A Aortic Dissection. Heart Surg Forum. 2024;27(5):E459\u201364.","journal-title":"Heart Surg Forum"},{"key":"4486_CR12","doi-asserted-by":"crossref","unstructured":"Xu Y, Liu L-Z, Lu H-Q, Yang X-Q, Guo S-K, Tang Y-J, Gong K-M: Risk factors for postoperative hepatic dysfunction in overweight patients with acute type A aortic dissection. BMC Surgery 2024, 24(1):305.","DOI":"10.1186\/s12893-024-02621-x"},{"key":"4486_CR13","doi-asserted-by":"crossref","unstructured":"Sheng W, Qiao H, Wang Z, Niu Z, Lv X: Analysis of prognosis and risk factors for postoperative hepatic dysfunction in patients with acute type A aortic dissection. The Anatolian Journal of Cardiology 2023, 27(4):197-204.","DOI":"10.14744\/AnatolJCardiol.2022.2644"},{"key":"4486_CR14","doi-asserted-by":"crossref","unstructured":"Lin X, Xie L, Jiang D, Wu Q, He J, Chen L: Hepatic dysfunction and adverse outcomes after total arch repair of acute type A aortic dissection: application of the MELD-XI score. BMC Cardiovascular Disorders 2022, 22(1):491.","DOI":"10.1186\/s12872-022-02934-w"},{"key":"4486_CR15","doi-asserted-by":"crossref","unstructured":"Wang Z, Ge M, Chen C, Lu L, Zhang L, Wang D: Hepatic dysfunction in patients who received acute DeBakey type I aortic dissection repair surgery: incidence, risk factors, and long-term outcomes. Journal of Cardiothoracic Surgery 2021, 16(1):296.","DOI":"10.1186\/s13019-021-01676-8"},{"key":"4486_CR16","doi-asserted-by":"crossref","unstructured":"Liu M, Tan W, Yuan W, Wang T, Lu X, Liu N: Development and validation of a diagnostic model to predict the risk of ischemic liver injury after Stanford type A aortic dissection surgery. Frontiers in Cardiovascular Medicine 2021, 8:701537","DOI":"10.3389\/fcvm.2021.701537"},{"key":"4486_CR17","doi-asserted-by":"crossref","unstructured":"Liang S, Liu Y, Zhang B, Dun Y, Guo H, Qian X, Sun X: Postoperative hepatic dysfunction after frozen elephant trunk for type A aortic dissection. Frontiers in Cardiovascular Medicine 2021, 8:739606.","DOI":"10.3389\/fcvm.2021.739606"},{"issue":"8","key":"4486_CR18","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.21037\/jtd.2019.08.72","volume":"11","author":"W Zhou","year":"2019","unstructured":"Zhou W, Wang G, Liu Y, Tao Y, Du Z, Tang Y, Qiao F, Liu Y, Xu Z. Outcomes and risk factors of postoperative hepatic dysfunction in patients undergoing acute type A aortic dissection surgery. J Thorac Dis. 2019;11(8):3225\u201333.","journal-title":"J Thorac Dis"},{"key":"4486_CR19","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol. 2014;14:135.","journal-title":"BMC Med Res Methodol"},{"issue":"6","key":"4486_CR20","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1177\/0962280216669183","volume":"27","author":"D Luo","year":"2018","unstructured":"Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range. Stat Methods Med Res. 2018;27(6):1785\u2013805.","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"4486_CR21","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1053\/j.jvca.2018.02.037","volume":"32","author":"MM Chacon","year":"2018","unstructured":"Chacon MM, Schulte TE. Liver Dysfunction in Cardiac Surgery - What Causes It and Is There Anything We Can Do? J Cardiothorac Vasc Anesth. 2018;32(4):1719\u201321.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"2","key":"4486_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bpa.2015.04.001","volume":"29","author":"N Di Tomasso","year":"2015","unstructured":"Di Tomasso N, Monaco F, Landoni G. Hepatic and renal effects of cardiopulmonary bypass. Best Pract Res Clin Anaesthesiol. 2015;29(2):151\u201361.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"2 Suppl","key":"4486_CR23","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1097\/00003246-199302001-00013","volume":"21","author":"RT Mathie","year":"1993","unstructured":"Mathie RT. Hepatic blood flow during cardiopulmonary bypass. Crit Care Med. 1993;21(2 Suppl):S72\u201376.","journal-title":"Crit Care Med"},{"issue":"1","key":"4486_CR24","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/s12872-025-04775-9","volume":"25","author":"Y Xin","year":"2025","unstructured":"Xin Y, Lyu S, Wang J, Wang Y, Shu Y, Liang H, Yang Y. Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection. BMC Cardiovasc Disord. 2025;25(1):323.","journal-title":"BMC Cardiovasc Disord"},{"key":"4486_CR25","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.2147\/JIR.S382573","volume":"15","author":"Z Li","year":"2022","unstructured":"Li Z, Zhang H, Baraghtha S, Mu J, Matniyaz Y, Jiang X, Wang K, Wang D, Xue YX. Short- and Mid-Term Survival Prediction in Patients with Acute Type A Aortic Dissection Undergoing Surgical Repair: Based on the Systemic Immune-Inflammation Index. J Inflamm Res. 2022;15:5785\u201399.","journal-title":"J Inflamm Res"},{"issue":"2","key":"4486_CR26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3906\/sag-1301-136","volume":"44","author":"G Laf\u00e7i","year":"2014","unstructured":"Laf\u00e7i G, Ci\u00e7ek \u00d6F, Uzun HA, Yal\u00e7inkaya A, Diken A, Turak O, \u00c7a\u011fli K, Ta\u015fo\u011flu \u0130, Gedik HS, Korkmaz K, et al. Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection. Turk J Med Sci. 2014;44(2):186\u201392.","journal-title":"Turk J Med Sci"},{"issue":"1","key":"4486_CR27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.arr.2008.08.001","volume":"8","author":"F Luo","year":"2009","unstructured":"Luo F, Zhou XL, Li JJ, Hui RT. Inflammatory response is associated with aortic dissection. Ageing Res Rev. 2009;8(1):31\u20135.","journal-title":"Ageing Res Rev"},{"issue":"12","key":"4486_CR28","doi-asserted-by":"publisher","first-page":"101602","DOI":"10.1016\/j.jhepr.2025.101602","volume":"7","author":"H Zheng","year":"2025","unstructured":"Zheng H, Wu K, Zheng H, Chen G, Lan Y, Chen S, Casu G, Sechi LA, Wu S, Vidili G, et al. High systemic inflammation response index and increased cardiovascular risk and mortality in MASLD: A prospective cohort study. JHEP Rep. 2025;7(12):101602.","journal-title":"JHEP Rep"},{"key":"4486_CR29","doi-asserted-by":"publisher","first-page":"1623899","DOI":"10.3389\/fimmu.2025.1623899","volume":"16","author":"S Tan","year":"2025","unstructured":"Tan S, Yang X, Mu X, Liu S, Wang Y, Li Y, Bian Y, Xu C. The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn\u2019s disease: a systematic review and meta-analysis. Front Immunol. 2025;16:1623899.","journal-title":"Front Immunol"},{"key":"4486_CR30","doi-asserted-by":"publisher","unstructured":"Awad MKA, Ali AE, Mazroua MS, Ali K, Awad RK, Mohamed TR, Abdelmaksoud M, Hashim MA, Nikollari R, Vardas PN et al: Updated evidence on peri-operative neutrophil-to-lymphocyte ratio in cardiac surgery: a dual analysis of prognostic and diagnostic value for post-operative atrial fibrillation. Heart Rhythm 2025. https:\/\/doi.org\/10.1016\/j.hrthm.2025.09.036.","DOI":"10.1016\/j.hrthm.2025.09.036"},{"issue":"1","key":"4486_CR31","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12933-022-01701-7","volume":"21","author":"D Wu","year":"2022","unstructured":"Wu D, Lan Y, Xu Y, Xu S, Huang Y, Balmer L, Maharra G, Xu W, Wang W, Wu S. Association of cumulative monocyte to high-density lipoprotein ratio with the risk of type 2 diabetes: a prospective cohort study. Cardiovasc Diabetol. 2022;21(1):268.","journal-title":"Cardiovasc Diabetol"},{"key":"4486_CR32","doi-asserted-by":"publisher","first-page":"1224068","DOI":"10.3389\/fsurg.2024.1224068","volume":"11","author":"D Banerjee","year":"2024","unstructured":"Banerjee D, Feng J, Sellke FW. Strategies to attenuate maladaptive inflammatory response associated with cardiopulmonary bypass. Front Surg. 2024;11:1224068.","journal-title":"Front Surg"},{"issue":"6","key":"4486_CR33","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1213\/ANE.0000000000001807","volume":"124","author":"K Karkouti","year":"2017","unstructured":"Karkouti K, Callum JL, Acker JP, Yip P, Rao V. Red Cell Transfusion-Associated Hemolysis in Cardiac Surgery: An Observational Cohort Study. Anesth Analg. 2017;124(6):1986\u201391.","journal-title":"Anesth Analg"},{"issue":"Suppl 1","key":"4486_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/anae.12891","volume":"70","author":"D Orlov","year":"2015","unstructured":"Orlov D, Karkouti K. The pathophysiology and consequences of red blood cell storage. Anaesthesia. 2015;70(Suppl 1):29\u201337. e29-12.","journal-title":"Anaesthesia"},{"issue":"1","key":"4486_CR35","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1038\/s41598-024-51784-3","volume":"14","author":"J Xiang","year":"2024","unstructured":"Xiang J, He L, Pen T, Li D, Wei S. Outcomes of two-stage type II hybrid aortic arch repair in elderly patients with acute type A aortic dissection. Sci Rep. 2024;14(1):1522.","journal-title":"Sci Rep"},{"issue":"6","key":"4486_CR36","first-page":"7047","volume":"13","author":"Z Zheng","year":"2021","unstructured":"Zheng Z, Yang L, Zhang Z, Wang D, Zong J, Zhang L, Wang X. Early and late outcomes of non-total aortic arch replacement for repair of acute Stanford Type A aortic dissection. Am J Transl Res. 2021;13(6):7047\u201352.","journal-title":"Am J Transl Res"},{"issue":"4","key":"4486_CR37","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1093\/icvts\/ivaa121","volume":"31","author":"Y Liu","year":"2020","unstructured":"Liu Y, Liang S, Zhang B, Li Y, Wang L, Dun Y, Chen Z, Shi Y, Guo H, Sun X. Early outcomes of hybrid type II arch repair versus total arch replacement with frozen elephant trunk in acute DeBakey type I aortic dissection: a propensity score-matched analysis. Interact Cardiovasc Thorac Surg. 2020;31(4):565\u201372.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"4486_CR38","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s13019-021-01643-3","volume":"16","author":"L Wang","year":"2021","unstructured":"Wang L, Li Y, Dun Y, Sun X. Risk factor analysis of clinical outcomes of total aortic arch replacement and frozen elephant trunk with aortic balloon occlusion. J Cardiothorac Surg. 2021;16(1):256.","journal-title":"J Cardiothorac Surg"},{"issue":"1","key":"4486_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jtcvs.2019.08.074","volume":"161","author":"Y Liu","year":"2021","unstructured":"Liu Y, Shi Y, Guo H, Yu C, Qian X, Wang W, Sun X. Aortic balloon occlusion technique versus moderate hypothermic circulatory arrest with antegrade cerebral perfusion in total arch replacement and frozen elephant trunk for acute type A aortic dissection. J Thorac Cardiovasc Surg. 2021;161(1):25\u201333.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"4486_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12872-021-02002-9","volume":"21","author":"J Lin","year":"2021","unstructured":"Lin J, Qin Z, Liu X, Xiong J, Wu Z, Guo Y, Kang D, Du L. Retrograde inferior vena caval perfusion for total aortic arch replacement surgery: a randomized pilot study. BMC Cardiovasc Disord. 2021;21(1):193.","journal-title":"BMC Cardiovasc Disord"},{"issue":"8","key":"4486_CR41","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1053\/j.jvca.2021.02.046","volume":"35","author":"S Shi","year":"2021","unstructured":"Shi S, Lei G, Yang L, Zhang C, Fang Z, Li J, Wang G. Using Machine Learning to Predict Postoperative Liver Dysfunction After Aortic Arch Surgery. J Cardiothorac Vasc Anesth. 2021;35(8):2330\u20135.","journal-title":"J Cardiothorac Vasc Anesth"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-026-04486-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-026-04486-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-026-04486-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:36:23Z","timestamp":1789086983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13019-026-04486-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4486"],"URL":"https:\/\/doi.org\/10.1186\/s13019-026-04486-y","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. This study is a systematic review and meta-analysis based on previously published data and did not involve new recruitment of human participants, collection of identifiable personal data, or any clinical intervention.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"692"}}