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This study evaluated whether intraoperative hemoadsorption can reduce bleeding in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing CABG within 24\u00a0h of clopidogrel discontinuation were randomized 1:1 to intraoperative hemoadsorption (Group 1) or control (Group 2). In the intervention group, the device was incorporated into the cardiopulmonary bypass (CPB) circuit. Efficacy was assessed by 24-hour chest tube drainage (CTD), blood product transfusions and surgical revisions for bleeding control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 50 patients were randomized (mean age 64\u2009\u00b1\u20098.6 years, 82% male). There were no differences in baseline characteristics between groups. Group 1 showed significantly reduced median 24-hr CTD of 300mL [250\u2013400] vs. 500mL [400\u2013700],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003, transfusions of packed red blood cells 0 [0\u20131] vs. 1 [0\u20132] units,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), fresh frozen plasma 0 [0\u20130] vs. 2 [2\u20133] units,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and platelets 0 [0\u20130] vs. 2 [1\u20133] units,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 compared with Group 2. One revision for bleeding control occurred in Group 2 (4.0%). No device-related serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort of clopidogrel-treated patients undergoing CABG within 24\u00a0h of discontinuation, intraoperative hemoadsorption was associated with lower postoperative bleeding and transfusion requirements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-026-04607-7","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:05:48Z","timestamp":1785161148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized pilot trial of intraoperative hemoadsorption in clopidogrel treated patients undergoing urgent coronary artery bypass grafting"],"prefix":"10.1186","volume":"21","author":[{"given":"Alireza","family":"Jahangirifard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Bashir","family":"Mirtajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Is\u00b4haq","family":"Al-Aamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumait","family":"Al-Lawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymios N.","family":"Deliargyris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Mandegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"4607_CR1","doi-asserted-by":"publisher","first-page":"ezae265","DOI":"10.1093\/ejcts\/ezae265","volume":"66","author":"M Schoerghuber","year":"2024","unstructured":"Schoerghuber M, Kuenzer T, Biancari F, Dalen M, Hansson EC, Jeppsson A, Schlachtenberger G, Siegemund M, Voetsch A, Pregartner G, Lindenau I, Zimpfer D, Berghold A, Mahla E, Zirlik A. 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Cardiovasc Revasc Med. 2026;82:50\u20136.","journal-title":"Cardiovasc Revasc Med"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-026-04607-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-026-04607-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-026-04607-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:00:43Z","timestamp":1792717243000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-026-04607-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4607"],"URL":"https:\/\/doi.org\/10.1186\/s13019-026-04607-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9092053\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"11 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The trial was approved by the Biomedical Research Ethics Committee of Shahid Beheshti University of Medical Sciences, at Masih Daneshvari Hospital in Tehran (IR.SBMU.NRITLD.REC.1402.246) and all patients gave written informed consent.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Daniel Wendt is a full-time employee of CytoSorbents Europe GmbH, Berlin, GermanyEfthymios Deliargyris is a full-time employee of CytoSorbents Inc., Princeton, NJ, USA.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"837"}}