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However, its potential mechanism and chemical composition remains undertermined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, the chemical profile of GGEC ethyl acetate extract (EAE) was evaluated by HPLC-Q-TOF\u2013MS\/MS. The effects of EAE on intestinal barrier function and inflammation were investigated in IEC-6 cells and RAW264.7 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that 33 compounds were tentatively identified, including 12 soy isoflavones, 7 bile acids for the first time in EAE. EAE significantly reinforced intestinal barrier function via increasing the tight junction protein levels of ZO-1 and Occludin, reducing the mRNA expression levels of interleukin (IL)-1\u03b2 and IL-6 in tumor necrosis factor alpha (TNF-\u03b1)-challenged IEC-6 cells. The scratch wound assay showed that EAE accelerated wound healing of IEC-6 cells. EAE evidently reduced the level of NO in a dose-dependent manner with an IC<jats:sub>50<\/jats:sub>value of 18.12\u00a0\u03bcg\/mL, and the mRNA expression of TNF-\u03b1, IL-1\u03b2, IL-6, iNOS and COX-2 in LPS-treated RAW264.7 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed the intestinal barrier protective effects and chemical profile of GGEC, and the results indicated that GGEC strengthened the intestinal barrier by up-regulating protein expression of tight junctions and limiting inflammatory responses.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13020-021-00432-3","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T17:17:14Z","timestamp":1613582234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Galli gigeriae endothelium corneum: its intestinal barrier protective activity in vitro and chemical composition"],"prefix":"10.1186","volume":"16","author":[{"given":"Shanshan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5769-9989","authenticated-orcid":false,"given":"Jihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"issue":"4","key":"432_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/md17040205","volume":"17","author":"SJ Jeong","year":"2019","unstructured":"Jeong SJ, Choi JW, Lee MK, Choi YH, Nam TJ. 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