{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:04:40Z","timestamp":1782486280151,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Three Year Action Plan Project of Shanghai Accelerating Development of Traditional Chinese Medicine","award":["ZY(2018-2020)-CCCX-2003-08"],"award-info":[{"award-number":["ZY(2018-2020)-CCCX-2003-08"]}]},{"name":"The Three Year Action Plan Project of Shanghai Accelerating Development of Traditional Chinese Medicine","award":["ZY(2018-2020)-FWTX-7005"],"award-info":[{"award-number":["ZY(2018-2020)-FWTX-7005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n We aim to study the clinical effect of moxibustion at Laogong interval with\n Panax notoginseng<\/jats:italic>\n on the short-term maturation and long-term patency of arteriovenous fistula.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Seventy-four pre-dialysis uremic patients who received distal forearm radial-cephalic fistula creations were enrolled in this study and randomly assigned to the control group and experimental group. After arteriovenous fistula creations, the control group underwent handgrip exercise, and the experimental group received moxibustion at Laogong acupoint interval with\n Panax notoginseng<\/jats:italic>\n . Both groups received a 12-week treatment and were followed up for 24\u00a0weeks in all at the following time points: before creations and 2, 4, 8, 12, 24\u00a0weeks after creations. The diameter of anastomosis, the diameter and outflow of draining-veins 5\u00a0cm above anastomosis, the diameter and outflow of brachial arteries evaluated the maturation and patency of arteriovenous fistula. Enzyme linked immunosorbent assay determined serum levels of endothelin and nitric oxide.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The maturity rate in the experimental group was significantly higher than that in the control group at 4\u00a0weeks after arteriovenous fistula creations (P\u2009=\u20090.048). The diameter of anastomosis, the diameter of draining veins, and the blood flow of draining veins increased in both groups during the whole 24\u00a0weeks. The diameter and blood flow of brachial arteries ascended in both groups during the previous 12\u00a0weeks. Compared with the control group, moxibustion at Laogong interval with\n Panax notoginseng<\/jats:italic>\n significantly improved the value of the diameter of draining-veins (P\u2009=\u20090.016), the blood flow of draining-veins (P\u2009=\u20090.015), the diameter of brachial arteries (P\u2009<\u20090.001), and the blood flow of brachial arteries (P\u2009=\u20090. 012) at 2\u00a0weeks, and enhanced the blood flow of draining-veins (P\u2009=\u20090.029) and brachial arteries (P\u2009<\u20090.001) at 12\u00a0weeks. Serum levels of endothelin were significantly lower (P\u2009=\u20090.047), and serum levels of nitric oxide were markedly higher (P\u2009<\u20090.001) in the experimental group than that in the control group at 2\u00a0weeks after creations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Moxibustion at Laogong interval with\n Panax notoginseng<\/jats:italic>\n was non-invasive and promoted the maturation of arteriovenous fistula at 4\u00a0weeks after creations. However, its long-term beneficial effect on patency at 24\u00a0weeks after creations was not significant.\n <\/jats:p>\n \n Trial registration<\/jats:italic>\n Chinese Clinical Trial Registry, No. ChiCTR1900024042. Registered,\n http:\/\/www.chictr.org.cn\/index.aspx<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13020-022-00604-9","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T07:04:43Z","timestamp":1650438283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A clinical randomized controlled trial: moxibustion at Laogong interval with Panax notoginseng promoted the maturation of arteriovenous fistulae"],"prefix":"10.1186","volume":"17","clinical-trial-number":[{"clinical-trial-number":"chictr1900024042","registry":"10.18810\/chictr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-8733","authenticated-orcid":false,"given":"Yurou","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luobing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianying","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5390-4626","authenticated-orcid":false,"given":"Chaoyang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"604_CR1","first-page":"367","volume":"18","author":"QZ Jin","year":"2019","unstructured":"Jin QZ, Wang YZ, Ye CY, et al. 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