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However, the mechanism of action is still unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Asthmatic SD rats were first sensitized and established through ovalbumin (OVA) motivation. Subsequently, Hematoxylin and eosin (H&amp;E) staining, Masson\u2019s trichrome (Masson) staining, Periodic acid-Schiff (PAS) staining and inflammatory\u00a0cytokines assay of interleukin (IL)-4, IL-6, IL-17 were implemented to evaluate the protective effects of\n                      <jats:italic>Chelidonium majus<\/jats:italic>\n                      on asthma. Then, the effects of\n                      <jats:italic>Chelidonium majus<\/jats:italic>\n                      and their molecular mechanisms of action on asthma were detected based on the integration of transcriptomics and metabolomics analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After administration with\n                      <jats:italic>Chelidonium majus<\/jats:italic>\n                      , the histological injuries of inflammation, collagen deposition and mucus secretion in lungs were attenuated and the serum inflammatory\u00a0cytokines perturbations were also converted. Furthermore, integrated analysis revealed that after\n                      <jats:italic>Chelidonium majus<\/jats:italic>\n                      treatment, 7 different expression genes (DEGs) (Alox15, P4ha1, Pla2g16, Pde3a, Nme1, Entpd8 and Adcy9) and 9 metabolic biomarkers (ADP, Xanthosine, Hypoxanthine, Inosine, prostaglandin E2 (PGE2), prostaglandin F2a (PGF2a), phosphatidylserine, Creatine and LysoPC (10:0)) were discovered to be connected with the enrichment metabolic pathways, including Purine metabolism, Arachidonic acid metabolism, Arginine and proline metabolism and Glycerophospholipid metabolism. The obtained metabolic biomarkers and DEGs were mainly related to energy metabolism and inflammation, and may be potential therapeutic targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Chelidonium majus<\/jats:italic>\n                      relieved OVA-induced asthma in rats by regulating the Alox15, P4ha1, Pla2g16, Pde3a, Nme1, Entpd8 and Adcy9 genes expression to restore the disorders in energy metabolism and inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13020-024-00932-y","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T10:02:19Z","timestamp":1714125739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying Chelidonium majus L. in the treatment of allergic asthma"],"prefix":"10.1186","volume":"19","author":[{"given":"Renguang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"issue":"4","key":"932_CR1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1183\/09031936.00087506","volume":"29","author":"ST Holgate","year":"2007","unstructured":"Holgate ST, Davies DE, Powell RM, Howarth PH, Haitchi HM, Holloway JW. 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