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Ferroptosis\u00a0has been shown to\u00a0play a key role in the injury process. In the present study, we wanted to explore whether electroacupuncture\u00a0could inhibit ferroptosis by promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The ischemic stroke\u00a0model was established by middle cerebral artery occlusion\/reperfusion (MCAO\/R) in adult rats.\u00a0These rats have been randomly divided into\u00a0the EA\u2009+\u2009MCAO\/R group, the MCAO\/R group,\u00a0the EA\u2009+\u2009MCAO\/R\u2009+\u2009Brusatol group (the\u00a0inhibitor of Nrf2), and the EA\u2009+\u2009MCAO\/R\u2009+\u2009DMSO group,\u00a0and the Sham group. The EA\u2009+\u2009MCAO\/R group, EA\u2009+\u2009MCAO\/R\u2009+\u2009Brusatol group, and the EA\u2009+\u2009MCAO\/R\u2009+\u2009DMSO group\u00a0received\u00a0EA intervention 24\u00a0h after modeling\u00a0for\u00a07 consecutive days. The behavioral function\u00a0was evaluated by Neurologic severity\u00a0score (NSS), Garcia score, Foot-fault Test, and Rotarod Test. The infarct volume was detected\u00a0by TTC staining, and the neuronal damage was observed by Nissl staining. The levels of Fe\n                      <jats:sup>2+<\/jats:sup>\n                      , reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured by ELISA. The immunofluorescence and Western blotting were used to detect the expression of Total Nrf2, p-Nrf2, Nuclear Nrf2, and Cytoplasmic Nrf2, and the essential ferroptosis proteins, including glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11) and ferritin heavy chain 1 (FTH1). The mitochondria were observed by transmission electron microscopy (TEM).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Electroacupuncture improved neurological deficits in rats model of MCAO\/R, decreased the brain infarct volume, alleviated neuronal damage, inhibited the Fe\n                      <jats:sup>2+<\/jats:sup>\n                      , ROS, and MDA accumulation, increased SOD levels, increased the expression of GPX4, SLC7A11 and FTH1, and rescued injured mitochondria. Especially, we found that the electroacupuncture up-regulated the expression of Nrf2, and promoted phosphorylation of\u00a0Nrf2 and nuclear translocation, However, Nrf2 inhibitor\u00a0Brusatol reversed the neuroprotective effect of electroacupuncture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Electroacupuncture\u00a0can\u00a0alleviate cerebral I\/R injury-induced ferroptosis by promoting Nrf2 nuclear translocation. It is expected that these data will provide novel insights into the mechanisms of electroacupuncture\u00a0protecting against cerebral I\/R injury and potential targets underlying ferroptosis in the stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13020-024-01047-0","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T01:15:10Z","timestamp":1735953310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2\/SLC7A11\/GPX4 pathway in ischemic stroke"],"prefix":"10.1186","volume":"20","author":[{"given":"Xi-chen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-2138","authenticated-orcid":false,"given":"Ya-ju","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-yue","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-chen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"issue":"10069","key":"1047_CR1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0140-6736(16)30962-X","volume":"389","author":"GJ Hankey","year":"2017","unstructured":"Hankey GJ. 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