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Subsequently, the lung pathological sections, lung function, the levels of oxidative stress and apoptosis, the metabolic levels in lung tissue and serum, and the levels of immune cells and inflammatory factors in each group of mice were detected. Then, the differentially expressed genes were screened based on the GEO database, and molecular docking combined with PCR technology was employed to investigate the potential pathogenesis of acute lung injury. Next, in vivo mouse models and in vitro lung organoid models were utilized, combined with Western blot and immunofluorescence techniques, to validate the proteins associated with the IL-17A\/NF-\u03baB signaling pathway. The binding of AAD to IL-17A protein was detected by cellular thermal shift assay (CETSA). Finally, the Beas-2B cell model combined with IL-17 agonist (SR0987) and IL-17 antagonist (Brodalumab), as well as the zebrafish model coupled with the methods of IL-17A gene silencing and overexpression, were employed to validate the mechanism of action underlying the intervention of AAD in LPS-induced ALI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AAD significantly ameliorated lung injury and lung function in a mouse model of LPS-induced ALI, modulated metabolic and immune disorders in ALI mice, and suppressed the release of inflammatory factors. The results from GEO database analysis, molecular docking, PCR, WB, immunofluorescence and CETSA, demonstrated that AAD ameliorates LPS-induced ALI via the IL-17A\/NF-\u03baB signaling pathway. In Beas-2B cells, AAD significantly suppressed the LPS-induced elevation of ROS and apoptosis levels, reduced the protein expression of IL-17A and p-NF-\u03baB p65, and decreased the levels of inflammatory factors, exerting a comparable therapeutic effect to that of the IL-17 antagonist. However, the therapeutic efficacy of AAD was abrogated following the addition of an IL-17 agonist. In the experiment of zebrafish, AAD significantly enhanced the sports activity of zebrafish and inhibited the levels of IL-17A and inflammatory factor RNA. However, the therapeutic efficacy of AAD was abrogated following IL-17A gene overexpression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AAD improves LPS-induced ALI through the IL-17A\/NF-\u03baB signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13020-026-01487-w","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:08:05Z","timestamp":1787540885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alisol A 23,24-diacetate improves LPS-induced acute lung injury through the IL-17A\/NF-\u03baB signaling pathway"],"prefix":"10.1186","volume":"21","author":[{"given":"Yuhan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-231X","authenticated-orcid":false,"given":"Xiaoke","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"5","key":"1487_CR1","doi-asserted-by":"publisher","first-page":"e12078","DOI":"10.1002\/jev2.12078","volume":"10","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Li Y, Liu P, Gong D, Zhou H, Li W, et al. 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