{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:43:50Z","timestamp":1770911030014,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Lymphatic Malformation Institute (LMI), Bethesda, MD"},{"name":"Lymphatic Malformation Institute (LMI), Bethesda, MD"},{"name":"Kungl. Fysiografiska S\u00e4llskapet i Lund, Lund, Sweden"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13023-016-0449-4","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T04:24:49Z","timestamp":1463545489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary and pleural lymphatic endothelial cells from pediatric, but not adult, patients with Gorham-Stout disease and generalized lymphatic anomaly, show a high proliferation rate"],"prefix":"10.1186","volume":"11","author":[{"given":"Michiko","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dictor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Brodszki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"L\u00f3pez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Beato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas S.","family":"Erjef\u00e4lt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik A.","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"issue":"1","key":"449_CR1","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1542\/peds.2014-3673","volume":"136","author":"M Wassef","year":"2015","unstructured":"Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, et al. Vascular anomalies classification: recommendations from the international society for the study of vascular anomalies. Pediatrics. 2015;136(1):e203\u201314. doi: 10.1542\/peds.2014-3673 .","journal-title":"Pediatrics"},{"issue":"4","key":"449_CR2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.sempedsurg.2014.07.006","volume":"23","author":"CC Trenor 3rd","year":"2014","unstructured":"Trenor 3rd CC, Chaudry G. Complex lymphatic anomalies. Semin Pediatr Surg. 2014;23(4):186\u201390. doi: 10.1053\/j.sempedsurg.2014.07.006 .","journal-title":"Semin Pediatr Surg"},{"issue":"5","key":"449_CR3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/pbc.25914","volume":"63","author":"M Ozeki","year":"2016","unstructured":"Ozeki M, Fujino A, Matsuoka K, Nosaka S, Kuroda T, Fukao T. Clinical features and prognosis of generalized lymphatic anomaly, kaposiform lymphangiomatosis, and Gorham-Stout disease. Pediatr Blood Cancer. 2016;63(5):832\u20138. doi: 10.1002\/pbc.25914 .","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"449_CR4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpeds.2013.10.013","volume":"164","author":"SE Croteau","year":"2014","unstructured":"Croteau SE, Kozakewich HP, Perez-Atayde AR, Fishman SJ, Alomari AI, Chaudry G, et al. Kaposiform lymphangiomatosis: a distinct aggressive lymphatic anomaly. J Pediatr. 2014;164(2):383\u20138. doi: 10.1016\/j.jpeds.2013.10.013 .","journal-title":"J Pediatr"},{"issue":"7","key":"449_CR5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00256-012-1565-4","volume":"42","author":"S Lala","year":"2013","unstructured":"Lala S, Mulliken JB, Alomari AI, Fishman SJ, Kozakewich HP, Chaudry G. Gorham-Stout disease and generalized lymphatic anomaly--clinical, radiologic, and histologic differentiation. Skeletal Radiol. 2013;42(7):917\u201324. doi: 10.1007\/s00256-012-1565-4 .","journal-title":"Skeletal Radiol"},{"issue":"4","key":"449_CR6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/lrb.2011.0023","volume":"9","author":"MN Satria","year":"2011","unstructured":"Satria MN, Pacheco-Rodriguez G, Moss J. Pulmonary lymphangiomatosis. Lymphat Res Biol. 2011;9(4):191\u20133. doi: 10.1089\/lrb.2011.0023 .","journal-title":"Lymphat Res Biol"},{"issue":"11","key":"449_CR7","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1651-2227.2011.02361.x","volume":"100","author":"N Brodszki","year":"2011","unstructured":"Brodszki N, Lansberg JK, Dictor M, Gyllstedt E, Ewers SB, Larsson MK, et al. A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax. Acta Paediatr. 2011;100(11):1448\u201353. doi: 10.1111\/j.1651-2227.2011.02361.x .","journal-title":"Acta Paediatr"},{"issue":"9094","key":"449_CR8","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/S0140-6736(05)63639-2","volume":"350","author":"H Hagberg","year":"1997","unstructured":"Hagberg H, Lamberg K, Astrom G. Alpha-2b interferon and oral clodronate for Gorham\u2019s disease. Lancet. 1997;350(9094):1822\u20133. doi: 10.1016\/S0140-6736(05)63639-2 .","journal-title":"Lancet"},{"issue":"4","key":"449_CR9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ppul.22869","volume":"49","author":"V Nir","year":"2014","unstructured":"Nir V, Guralnik L, Livnat G, Bar-Yoseph R, Hakim F, Ilivitzki A, et al. Propranolol as a treatment option in Gorham-Stout syndrome: a case report. Pediatr Pulmonol. 2014;49(4):417\u20139. doi: 10.1002\/ppul.22869 .","journal-title":"Pediatr Pulmonol"},{"issue":"8","key":"449_CR10","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/annonc\/mdq331","volume":"21","author":"TG Grunewald","year":"2010","unstructured":"Grunewald TG, Damke L, Maschan M, Petrova U, Surianinova O, Esipenko A, et al. First report of effective and feasible treatment of multifocal lymphangiomatosis (Gorham-Stout) with bevacizumab in a child. Ann Oncol. 2010;21(8):1733\u20134. doi: 10.1093\/annonc\/mdq331 .","journal-title":"Ann Oncol"},{"key":"449_CR11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1465-9921-14-65","volume":"14","author":"M Mori","year":"2013","unstructured":"Mori M, Andersson CK, Graham GJ, Lofdahl CG, Erjefalt JS. Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD. Respir Res. 2013;14:65. doi: 10.1186\/1465-9921-14-65 .","journal-title":"Respir Res"},{"issue":"6","key":"449_CR12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/thoraxjnl-2012-202879","volume":"68","author":"M Mori","year":"2013","unstructured":"Mori M, Andersson CK, Svedberg KA, Glader P, Bergqvist A, Shikhagaie M, et al. Appearance of remodelled and dendritic cell-rich alveolar-lymphoid interfaces provides a structural basis for increased alveolar antigen uptake in chronic obstructive pulmonary disease. Thorax. 2013;68(6):521\u201331. doi: 10.1136\/thoraxjnl-2012-202879 .","journal-title":"Thorax"},{"issue":"8","key":"449_CR13","doi-asserted-by":"crossref","first-page":"e481","DOI":"10.1097\/MPH.0000000000000436","volume":"37","author":"J Rossler","year":"2015","unstructured":"Rossler J, Saueressig U, Kayser G, von Winterfeld M, Klement GL. Personalized therapy for generalized lymphatic anomaly\/Gorham-Stout disease with a combination of sunitinib and taxol. J Pediatr Hematol Oncol. 2015;37(8):e481\u20135. doi: 10.1097\/MPH.0000000000000436 .","journal-title":"J Pediatr Hematol Oncol"},{"issue":"14","key":"449_CR14","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1056\/NEJMc1013217","volume":"364","author":"M Ozeki","year":"2011","unstructured":"Ozeki M, Fukao T, Kondo N. Propranolol for intractable diffuse lymphangiomatosis. N Engl J Med. 2011;364(14):1380\u20132. doi: 10.1056\/NEJMc1013217 .","journal-title":"N Engl J Med"},{"issue":"3","key":"449_CR15","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.ijrobp.2011.01.006","volume":"81","author":"R Heyd","year":"2011","unstructured":"Heyd R, Micke O, Surholt C, Berger B, Martini C, Fuller J, et al. Radiation therapy for Gorham-Stout syndrome: results of a national patterns-of-care study and literature review. Int J Radiat Oncol Biol Phys. 2011;81(3):e179\u201385. doi: 10.1016\/j.ijrobp.2011.01.006 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"449_CR16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11748-012-0130-3","volume":"61","author":"M Noda","year":"2013","unstructured":"Noda M, Endo C, Hoshikawa Y, Ishibashi N, Suzuki T, Okada Y, et al. Successful management of intractable chylothorax in Gorham-Stout disease by awake thoracoscopic surgery. Gen Thorac Cardiovasc Surg. 2013;61(6):356\u20138. doi: 10.1007\/s11748-012-0130-3 .","journal-title":"Gen Thorac Cardiovasc Surg"},{"issue":"4","key":"449_CR17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0003-4975(10)60078-1","volume":"40","author":"MA Bhatti","year":"1985","unstructured":"Bhatti MA, Ferrante JW, Gielchinsky I, Norman JC. Pleuropulmonary and skeletal lymphangiomatosis with chylothorax and chylopericardium. Ann Thorac Surg. 1985;40(4):398\u2013401.","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"449_CR18","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","volume":"140","author":"T Tammela","year":"2010","unstructured":"Tammela T, Alitalo K. Lymphangiogenesis: molecular mechanisms and future promise. Cell. 2010;140(4):460\u201376. doi: 10.1016\/j.cell.2010.01.045 .","journal-title":"Cell"},{"issue":"12","key":"449_CR19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ncponc0660","volume":"3","author":"J Hagendoorn","year":"2006","unstructured":"Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, et al. Platelet-derived growth factor receptor-beta in Gorham\u2019s disease. Nat Clin Pract Oncol. 2006;3(12):693\u20137. doi: 10.1038\/ncponc0660 .","journal-title":"Nat Clin Pract Oncol"},{"issue":"5","key":"449_CR20","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCRESAHA.114.303119","volume":"114","author":"LC Yao","year":"2014","unstructured":"Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, et al. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res. 2014;114(5):806\u201322. doi: 10.1161\/CIRCRESAHA.114.303119 .","journal-title":"Circ Res"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-016-0449-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T09:52:50Z","timestamp":1498297970000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-016-0449-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["449"],"URL":"https:\/\/doi.org\/10.1186\/s13023-016-0449-4","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]},"article-number":"67"}}