{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:18:22Z","timestamp":1785374302108,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082283"],"award-info":[{"award-number":["R01NS082283"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charlotte and Gwenyth Gray Foundation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103548"],"award-info":[{"award-number":["P20GM103548"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103620"],"award-info":[{"award-number":["P20GM103620"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13023-019-0994-8","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T14:02:51Z","timestamp":1548079371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tracking sex-dependent differences in a mouse model of CLN6-Batten disease"],"prefix":"10.1186","volume":"14","author":[{"given":"McKayla J.","family":"Poppens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob T.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler B.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha S.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Laufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Kloth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-4942","authenticated-orcid":false,"given":"Jill M.","family":"Weimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"issue":"2","key":"994_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/00019052-200304000-00001","volume":"16","author":"JD Cooper","year":"2003","unstructured":"Cooper JD. Progress towards understanding the neurobiology of batten disease or neuronal ceroid lipofuscinosis. Curr Opin Neurol. 2003;16(2):121\u20138.","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"994_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10048-005-0218-3","volume":"6","author":"SE Mole","year":"2005","unstructured":"Mole SE, Williams RE, Goebel HH. Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses. Neurogenetics. 2005;6(3):107\u201326.","journal-title":"Neurogenetics"},{"issue":"1","key":"994_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1750-3639.2004.tb00499.x","volume":"14","author":"HH Goebel","year":"2004","unstructured":"Goebel HH, Wisniewski KE. Current state of clinical and morphological features in human NCL. Brain Pathol. 2004;14(1):61\u20139.","journal-title":"Brain Pathol"},{"issue":"11","key":"994_CR4","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/j.bbadis.2013.05.014","volume":"1832","author":"DN Palmer","year":"2013","unstructured":"Palmer DN, Barry LA, Tyynela J, Cooper JD. NCL disease mechanisms. Biochim Biophys Acta. 2013;1832(11):1882\u201393.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"994_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnen\/62.1.1","volume":"62","author":"M Haltia","year":"2003","unstructured":"Haltia M. The neuronal ceroid-lipofuscinoses. J Neuropathol Exp Neurol. 2003;62(1):1\u201313.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"994_CR6","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.bbamcr.2008.11.004","volume":"1793","author":"A Jalanko","year":"2009","unstructured":"Jalanko A, Braulke T. Neuronal ceroid lipofuscinoses. Biochim Biophys Acta. 2009;1793(4):697\u2013709.","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"994_CR7","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.bbadis.2013.03.017","volume":"1832","author":"V Warrier","year":"2013","unstructured":"Warrier V, Vieira M, Mole SE. Genetic basis and phenotypic correlations of the neuronal ceroid lipofusinoses. Biochim Biophys Acta (BBA) - Mol Basis Dis. 2013;1832(11):1827\u201330.","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"issue":"2","key":"994_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1086\/338190","volume":"70","author":"H Gao","year":"2002","unstructured":"Gao H, Boustany RM, Espinola JA, Cotman SL, Srinidhi L, Antonellis KA, et al. Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. Am J Hum Genet. 2002;70(2):324\u201335.","journal-title":"Am J Hum Genet"},{"issue":"1","key":"994_CR9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/humu.10227","volume":"22","author":"JD Sharp","year":"2003","unstructured":"Sharp JD, Wheeler RB, Parker KA, Gardiner RM, Williams RE, Mole SE. Spectrum of CLN6 mutations in variant late infantile neuronal ceroid lipofuscinosis. Hum Mutat. 2003;22(1):35\u201342.","journal-title":"Hum Mutat"},{"issue":"5","key":"994_CR10","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/humu.10207","volume":"21","author":"CA Teixeira","year":"2003","unstructured":"Teixeira CA, Espinola J, Huo L, Kohlschutter J, Persaud Sawin DA, Minassian B, et al. Novel mutations in the CLN6 gene causing a variant late infantile neuronal ceroid lipofuscinosis. Hum Mutat. 2003;21(5):502\u20138.","journal-title":"Hum Mutat"},{"issue":"4","key":"994_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/(SICI)1096-8628(19980526)77:4<289::AID-AJMG8>3.0.CO;2-I","volume":"77","author":"RT Bronson","year":"1998","unstructured":"Bronson RT, Donahue LR, Johnson KR, Tanner A, Lane PW, Faust JR. Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9. Am J Med Genet. 1998;77(4):289\u201397.","journal-title":"Am J Med Genet"},{"issue":"1","key":"994_CR12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1365-2990.1995.tb01028.x","volume":"21","author":"RD Jolly","year":"1995","unstructured":"Jolly RD, Palmer DN. The neuronal ceroid-lipofuscinoses (batten disease): comparative aspects. Neuropathol Appl Neurobiol. 1995;21(1):50\u201360.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"6","key":"994_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/00480169.1976.34298","volume":"24","author":"RD Jolly","year":"1976","unstructured":"Jolly RD, West DM. Blindness in South Hampshire sheep: a neuronal ceroidlipofuscinosis. N Z Vet J. 1976;24(6):123.","journal-title":"N Z Vet J"},{"issue":"1\u20132","key":"994_CR14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/jnr.23955","volume":"95","author":"LC Golden","year":"2017","unstructured":"Golden LC, Voskuhl R. The importance of studying sex differences in disease: the example of multiple sclerosis. J Neurosci Res. 2017;95(1\u20132):633\u201343.","journal-title":"J Neurosci Res"},{"issue":"3","key":"994_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","volume":"35","author":"AK Beery","year":"2011","unstructured":"Beery AK, Zucker I. Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev. 2011;35(3):565\u201372.","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"994_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.yfrne.2014.01.002","volume":"35","author":"R Li","year":"2014","unstructured":"Li R, Singh M. Sex differences in cognitive impairment and Alzheimer\u2019s disease. Front Neuroendocrinol. 2014;35(3):385\u2013403.","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"994_CR17","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.yfrne.2014.02.002","volume":"35","author":"GE Gillies","year":"2014","unstructured":"Gillies GE, Pienaar IS, Vohra S, Qamhawi Z. Sex differences in Parkinson\u2019s disease. Front Neuroendocrinol. 2014;35(3):370\u201384.","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"994_CR18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.yfrne.2014.03.003","volume":"35","author":"W Davies","year":"2014","unstructured":"Davies W. Sex differences in attention deficit hyperactivity disorder: candidate genetic and endocrine mechanisms. Front Neuroendocrinol. 2014;35(3):331\u201346.","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"994_CR19","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.yfrne.2014.03.006","volume":"35","author":"SM Schaafsma","year":"2014","unstructured":"Schaafsma SM, Pfaff DW. Etiologies underlying sex differences in autism Spectrum disorders. Front Neuroendocrinol. 2014;35(3):255\u201371.","journal-title":"Front Neuroendocrinol"},{"key":"994_CR20","doi-asserted-by":"publisher","first-page":"676531","DOI":"10.1155\/2015\/676531","volume":"2015","author":"H Attarian","year":"2015","unstructured":"Attarian H, Brandes J, Dafer R, Gerard E, Giesser B. Sex differences in the study of neurological illnesses. Behav Neurol. 2015;2015:676531.","journal-title":"Behav Neurol"},{"issue":"3","key":"994_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s10545-011-9421-6","volume":"35","author":"J Cialone","year":"2012","unstructured":"Cialone J, Adams H, Augustine EF, Marshall FJ, Kwon JM, Newhouse N, et al. Females experience a more severe disease course in batten disease. J Inherit Metab Dis. 2012;35(3):549\u201355.","journal-title":"J Inherit Metab Dis"},{"issue":"6","key":"994_CR22","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/0092-8674(95)90274-0","volume":"82","author":"Isolation of a novel gene underlying Batten disease, CLN3","year":"1995","unstructured":"Isolation of a novel gene underlying Batten disease, CLN3. The international batten disease consortium. Cell. 1995;82(6):949\u201357.","journal-title":"Cell"},{"issue":"22","key":"994_CR23","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1093\/hmg\/11.22.2709","volume":"11","author":"SL Cotman","year":"2002","unstructured":"Cotman SL, Vrbanac V, Lebel LA, Lee RL, Johnson KA, Donahue LR, et al. Cln3(Deltaex7\/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth. Hum Mol Genet. 2002;11(22):2709\u201321.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"994_CR24","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1242\/dmm.018804","volume":"8","author":"AD Kovacs","year":"2015","unstructured":"Kovacs AD, Pearce DA. Finding the most appropriate mouse model of juvenile CLN3 (batten) disease for therapeutic studies: the importance of genetic background and gender. Dis Model Mech. 2015;8(4):351\u201361.","journal-title":"Dis Model Mech"},{"issue":"1\u20132","key":"994_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.brainres.2004.04.040","volume":"1014","author":"R Guarneri","year":"2004","unstructured":"Guarneri R, Russo D, Cascio C, D'Agostino S, Galizzi G, Bigini P, et al. Retinal oxidation, apoptosis and age- and sex-differences in the mnd mutant mouse, a model of neuronal ceroid lipofuscinosis. Brain Res. 2004;1014(1\u20132):209\u201320.","journal-title":"Brain Res"},{"issue":"4","key":"994_CR26","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.bbrc.2008.12.159","volume":"379","author":"N Cannelli","year":"2009","unstructured":"Cannelli N, Garavaglia B, Simonati A, Aiello C, Barzaghi C, Pezzini F, et al. Variant late infantile ceroid lipofuscinoses associated with novel mutations in CLN6. Biochem Biophys Res Commun. 2009;379(4):892\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"994_CR27","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1212\/WNL.0000000000001784","volume":"85","author":"L Canafoglia","year":"2015","unstructured":"Canafoglia L, Gilioli I, Invernizzi F, Sofia V, Fugnanesi V, Morbin M, et al. Electroclinical spectrum of the neuronal ceroid lipofuscinoses associated with CLN6 mutations. Neurology. 2015;85(4):316\u201324.","journal-title":"Neurology"},{"issue":"2","key":"994_CR28","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1086\/514846","volume":"61","author":"PB Munroe","year":"1997","unstructured":"Munroe PB, Mitchison HM, O'Rawe AM, Anderson JW, Boustany RM, Lerner TJ, et al. Spectrum of mutations in the batten disease gene, CLN3. Am J Hum Genet. 1997;61(2):310\u20136.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"994_CR29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.steroids.2007.02.003","volume":"72","author":"DW Brann","year":"2007","unstructured":"Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM. Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids. 2007;72(5):381\u2013405.","journal-title":"Steroids"},{"issue":"3","key":"994_CR30","first-page":"279","volume":"20","author":"BS McEwen","year":"1999","unstructured":"McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev. 1999;20(3):279\u2013307.","journal-title":"Endocr Rev"},{"issue":"1\u20132","key":"994_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0006-8993(93)90964-O","volume":"628","author":"J Garcia-Estrada","year":"1993","unstructured":"Garcia-Estrada J, Del Rio JA, Luquin S, Soriano E, Garcia-Segura LM. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res. 1993;628(1\u20132):271\u20138.","journal-title":"Brain Res"},{"issue":"10","key":"994_CR32","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1111\/j.1460-9568.2007.05563.x","volume":"25","author":"G Barreto","year":"2007","unstructured":"Barreto G, Veiga S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur J Neurosci. 2007;25(10):3039\u201346.","journal-title":"Eur J Neurosci"},{"issue":"2","key":"994_CR33","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.yhbeh.2012.02.021","volume":"63","author":"MA Arevalo","year":"2013","unstructured":"Arevalo MA, Santos-Galindo M, Acaz-Fonseca E, Azcoitia I, Garcia-Segura LM. Gonadal hormones and the control of reactive gliosis. Horm Behav. 2013;63(2):216\u201321.","journal-title":"Horm Behav"},{"issue":"11","key":"994_CR34","doi-asserted-by":"publisher","first-page":"5010","DOI":"10.1210\/en.2009-0352","volume":"150","author":"G Barreto","year":"2009","unstructured":"Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernia O, Carrero P, Azcoitia I, et al. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology. 2009;150(11):5010\u20135.","journal-title":"Endocrinology"},{"key":"994_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbi.2017.03.010","volume":"64","author":"LH Nelson","year":"2017","unstructured":"Nelson LH, Warden S, Lenz KM. Sex differences in microglial phagocytosis in the neonatal hippocampus. Brain Behav Immun. 2017;64:11\u201322.","journal-title":"Brain Behav Immun"},{"issue":"3","key":"994_CR36","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/glia.23263","volume":"66","author":"N Yanguas-Casas","year":"2018","unstructured":"Yanguas-Casas N, Crespo-Castrillo A, de Ceballos ML, Chowen JA, Azcoitia I, Arevalo MA, et al. Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid. Glia. 2018;66(3):522\u201337.","journal-title":"Glia"},{"issue":"10","key":"994_CR37","doi-asserted-by":"publisher","first-page":"8071","DOI":"10.1007\/s12035-016-0297-1","volume":"54","author":"M Sochocka","year":"2017","unstructured":"Sochocka M, Diniz BS, Leszek J. Inflammatory response in the CNS: friend or foe? Mol Neurobiol. 2017;54(10):8071\u201389.","journal-title":"Mol Neurobiol"},{"issue":"6","key":"994_CR38","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1471-4159.2011.07630.x","volume":"120","author":"JM Schwarz","year":"2012","unstructured":"Schwarz JM, Sholar PW, Bilbo SD. Sex differences in microglial colonization of the developing rat brain. J Neurochem. 2012;120(6):948\u201363.","journal-title":"J Neurochem"},{"key":"994_CR39","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.comppsych.2015.07.002","volume":"62","author":"S Kim","year":"2015","unstructured":"Kim S, Kim MJ, Kim S, Kang HS, Lim SW, Myung W, et al. Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: a CREDOS study. Compr Psychiatry. 2015;62:114\u201322.","journal-title":"Compr Psychiatry"},{"issue":"2","key":"994_CR40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.gene.2013.02.022","volume":"519","author":"S Kang","year":"2013","unstructured":"Kang S, Kim JB, Heo TH, Kim SJ. Cell cycle arrest in batten disease lymphoblast cells. Gene. 2013;519(2):245\u201350.","journal-title":"Gene"},{"issue":"5","key":"994_CR41","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1097\/01.bor.0000240354.37927.dd","volume":"18","author":"CM Grimaldi","year":"2006","unstructured":"Grimaldi CM. Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells. Curr Opin Rheumatol. 2006;18(5):456\u201361.","journal-title":"Curr Opin Rheumatol"},{"issue":"1\u20132","key":"994_CR42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jneuroim.2010.08.024","volume":"230","author":"SS Seehafer","year":"2011","unstructured":"Seehafer SS, Ramirez-Montealegre D, Wong AM, Chan CH, Castaneda J, Horak M, et al. Immunosuppression alters disease severity in juvenile batten disease mice. J Neuroimmunol. 2011;230(1\u20132):169\u201372.","journal-title":"J Neuroimmunol"},{"key":"994_CR43","doi-asserted-by":"crossref","unstructured":"Augustine EF, Beck CA, Adams HR, Defendorf S, Vierhile A, Timm D, et al. Short-term Administration of Mycophenolate is Well-Tolerated in CLN3 disease (juvenile neuronal ceroid Lipofuscinosis). JIMD Rep. 2018.","DOI":"10.1007\/8904_2018_113"},{"issue":"11","key":"994_CR44","doi-asserted-by":"publisher","first-page":"e78694","DOI":"10.1371\/journal.pone.0078694","volume":"8","author":"JP Morgan","year":"2013","unstructured":"Morgan JP, Magee H, Wong A, Nelson T, Koch B, Cooper JD, et al. A murine model of variant late infantile ceroid lipofuscinosis recapitulates behavioral and pathological phenotypes of human disease. PLoS One. 2013;8(11):e78694.","journal-title":"PLoS One"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-019-0994-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13023-019-0994-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-019-0994-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T07:14:10Z","timestamp":1720941250000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-019-0994-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["994"],"URL":"https:\/\/doi.org\/10.1186\/s13023-019-0994-8","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]},"assertion":[{"value":"21 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal protocols were approved by the Institutional Animal Care and Use Committees of each participating institute (NIH\/OLAW Assurance Number: A4568\u201301) with all procedures conducted in strict accordance with National Institutes of Health guidelines and Institutional Animal Care and Use Committee Guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"19"}}