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All these features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 47 Finnish women with CHH, we identified 14 women with ICD codes related to pregnancies, childbirth and puerperium in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were altogether 42 pregnancies in 14 women (median height 124\u00a0cm, range 105\u2013139\u00a0cm; 4\u20321\u2032\u2032, range 3\u20325\u2032\u2032\u20134\u20327\u2032\u2019). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5, and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25\/26 cases at full-term. In the majority, the birth length (median 48\u00a0cm, range 45.5\u201350\u00a0cm; 1\u20327\u2032\u2032, range 1\u20326\u2032\u2032\u20131\u20328\u2032\u2032) and weight (3010\u00a0g, range 2100\u20133320\u00a0g; 6.6\u00a0lb, range 4.6\u20137.3\u00a0lb) of the offspring in full-term singleton pregnancies was normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite CHH mothers\u2019 significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and planned cesarean section should be contemplated\u00a0in term pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13023-020-01614-2","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T17:56:29Z","timestamp":1605808589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-1337","authenticated-orcid":false,"given":"Elina","family":"Holopainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Vakkilainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"1614_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejogrb.2004.09.013","volume":"120","author":"E Sheiner","year":"2005","unstructured":"Sheiner E, Levy A, Katz M, Mazor M. 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Individual patients cannot be identified from the data shown.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"326"}}