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Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2\u00a0years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adequate levels of selenium were observed in 24\/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6\u00a0\u03bcg\/L (43.2\u201357.0) vs 54.6 (45.2\u201362.6) \u03bcg\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B\/Apo-A-I1, LDL-c\/HDL-c ratio, malondialdehyde [3.8\u00a0\u00b5g\/L vs 2.8\u00a0\u00b5g\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029] and lower Apo-A-I1\/HDL-c and glutathione peroxidase activity [7300 U\/L vs 8686 U\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC\u2009=\u20090.849) and ALT (AUC\u2009=\u20090.854) were the variables that showed the greatest discriminatory power between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13023-021-01732-5","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T15:35:32Z","timestamp":1613144132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2229-5359","authenticated-orcid":false,"given":"Itana Gomes Alves","family":"Andrade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola Isabel","family":"Suano-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Luiz Affonso","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Sanchez Aranda","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseli Oselka Saccardo","family":"Sarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"issue":"12","key":"1732_CR1","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1039\/c9mt00201d","volume":"11","author":"BR Cardoso","year":"2019","unstructured":"Cardoso BR, Ganio K, Roberts BR. 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