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The objective of this study was to investigate the findings of <jats:sup>68<\/jats:sup>Ga-NOTA-Evans Blue (NEB) PET\/CT in LAM and compare it with that of <jats:sup>99m<\/jats:sup>Tc-ASC lymphoscintigraphy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ten patients diagnosed with LAM according to the American Thoracic Society\/Japanese Respiratory Society guidelines for LAM were recruited in this study. PET\/CT acquisition was performed at 20 to 40\u00a0min after subcutaneous injection of <jats:sup>68<\/jats:sup>Ga-NEB into the first interdigital spaces of both feet (0.3\u00a0ml, 37\u00a0MBq\/foot). All subjects also underwent <jats:sup>99m<\/jats:sup>Tc-antimony sulfide colloid (ASC) lymphoscintigraphy within a week for comparison.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:sup>68<\/jats:sup>Ga-NEB PET\/CT displayed various lymphatic system abnormalities in 10 (100%) of 10 patients. These included pulmonary lymphatic abnormalities in 10 (100%) of 10 patients, enlarged lymph nodes in 5 (50%), lymphangioleiomyomas in 2 (20%), dilation of the lumbar trunk and\/or iliac lymph vessels in 5 (50%), thoracic duct dilation in 2 (20%), chylous effusion in 1 (10%). For pulmonary lymphatic abnormalities, the positive rates of <jats:sup>68<\/jats:sup>Ga-NEB PET\/CT and <jats:sup>99m<\/jats:sup>Tc-ASC lymphoscintigraphy were 100% (10\/10) and 10% (1\/10), respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). As for the 7 patients with extrapulmonary lymphatic manifestations, <jats:sup>68<\/jats:sup>Ga-NEB PET\/CT also presented more information than <jats:sup>99m<\/jats:sup>Tc-ASC lymphoscintigraphy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:sup>68<\/jats:sup>Ga-NEB PET\/CT visualized pulmonary lymphatic abnormality and displayed extrapulmonary lymphatic system disorders of LAM, and might play a role in the diagnosis and evaluation of the disease. <jats:sup>68<\/jats:sup>Ga-NEB PET\/CT is advantageous over conventional <jats:sup>99m<\/jats:sup>Tc-ASC lymphoscintigraphy in LAM by providing more detailed information of lymphatic dysfunction.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13023-021-01895-1","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T09:03:03Z","timestamp":1623834183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["68Ga-NOTA-Evans Blue PET\/CT findings in lymphangioleiomyomatosis compared with 99mTC-ASC lymphoscintigraphy: a prospective study"],"prefix":"10.1186","volume":"16","author":[{"given":"Guozhu","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-8113","authenticated-orcid":false,"given":"Wuying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"issue":"18","key":"1895_CR1","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1056\/NEJM199011013231807","volume":"323","author":"JR Taylor","year":"1990","unstructured":"Taylor JR, Ryu J, Colby TV, Raffin TA. 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