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Lumbar puncture was performed without sedation under ultrasound guidance using a 22G echogenic needle in the interlaminar aspect of the L4\u2013L5 or L5\u2013S1 interspace and a full dose of nusinersen (12\u00a0mg\/5\u00a0mL) was injected after visualizing free cerebrospinal fluid flow. Patients completed their four loading doses and one maintenance dose of nusinersen. All 15 procedures were successful and well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Real-time ultrasound-guided lumbar puncture is an effective and radiation-free technique to administer intrathecal nusinersen in SMA patients with severe scoliosis when done by practitioners with expertise in this procedure.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13023-021-01903-4","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T21:02:27Z","timestamp":1623618147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ultrasound-guided nusinersen administration for spinal muscular atrophy patients with severe scoliosis: an observational study"],"prefix":"10.1186","volume":"16","author":[{"given":"Jiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9570-1587","authenticated-orcid":false,"given":"Xulei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"1903_CR1","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1212\/WNL.0000000000007742","volume":"93","author":"CA Wijingaarde","year":"2019","unstructured":"Wijingaarde CA, Brink RC, de Kort FAS, Stam M, Otto LAM, Asselman FL, et al. 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