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Various conservative and surgical treatment approaches exist, but their impact on weight gain has not yet been adequately addressed. A functional treatment concept, used in our center for\u2009&gt;\u200920\u00a0years, includes a pre-epiglottic baton plate (Tuebingen palatal plate) and intensive feeding training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of the Tuebingen treatment protocol on growth and weight trajectories during infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed longitudinal data from infants with isolated RS admitted to Tuebingen University Children\u2019s Hospital, Germany between 1998 and 2019. Through our electronic patient database, we evaluated anthropometric parameters until reaching 1-year follow-up. Results are shown as median (IQR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 307 infants analyzed, median Z-score for weight decreased from \u2212\u00a00.28 at birth to \u2212\u00a01.12 upon admission to our center at a median age of 22\u00a0days. Z-score then remained largely unchanged until discharge (Z-score difference, \u2212\u00a00.08), while the proportion of infants receiving tube feedings decreased from 55.1 to 13.7%. Z-score subsequently increased from \u2212\u00a01.17 at discharge to \u2212\u00a00.44 at the 1-year follow-up (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on a comparatively large cohort, this functional treatment was associated with better weight gain and improved feeding. As RS infants often show postnatal growth failure, weight monitoring may be a valuable parameter for monitoring treatment effectiveness.<\/jats:p><jats:p><jats:italic>Clinical Trial Registration<\/jats:italic>Not necessary due to the retrospective design.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13023-021-01959-2","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:33:08Z","timestamp":1628832788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Retrospective study on growth in infants with isolated Robin sequence treated with the Tuebingen Palate Plate"],"prefix":"10.1186","volume":"16","author":[{"given":"Cornelia","family":"Wiechers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Iffl\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieke","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Ciuffolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Arand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Weise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel","family":"Grandke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegmar","family":"Reinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Koos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-0066","authenticated-orcid":false,"given":"Christian F.","family":"Poets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"issue":"5","key":"1959_CR1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1542\/peds.2010-2615","volume":"127","author":"KN Evans","year":"2011","unstructured":"Evans KN, Sie KC, Hopper RA, Glass RP, Hing AV, Cunningham ML. 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Ethics approval for this retrospective study was given by the Ethics committee of the Medical Faculty of the University of Tuebingen (Project number: 435\/2019 BO2, Ethik Kommission, Eberhard Karls University, Gartenstra\u00dfe 47, 72074 Tuebingen, Germany).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no financial relationship relevant to this article to disclose. The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"338"}}