{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:37Z","timestamp":1790806417483,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"this work is supported by clinical science innovation program of shanghai shenkang hospital development center","award":["SHDC12017129"],"award-info":[{"award-number":["SHDC12017129"]}]},{"name":"grants from project of east china hospital affiliated to fudan university","award":["20191c028"],"award-info":[{"award-number":["20191c028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Beh\u00e7et\u2019s\u00a0disease (BD) can involve any site of the alimentary canal. There has been research concerning intestinal BD. Nevertheless, the entire digestive tract not yet been studied extensively. Therefore, the purpose of study was to describe the prevalence, location, clinical features and possible risk factors of BD with gastrointestinal tract ulcer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a cross-sectional observational study that included 1232 consecutive BD patients who routinely underwent endoscopy upon their wishes. The clinical symptoms, endoscopic findings, and histologic features of BD with gastrointestinal ulcer and negative <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) were identified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>We found that 22.16% (273\/1232) BD patients had ulcers of the alimentary tract. At presentation, 61.54% (168\/273) patients were asymptomatic. Isolated gastroduodenal involvement is an extremely usual event. The second was the pairwise combination between bowel segments, and 24 cases involved three segments at the same time. One patient suffered from total gastrointestinal tract involvement. Inflammation was the most common histopathologic feature 77.60% (142\/183). The 273 BD patients with gastrointestinal ulcer were at greater risk of having archenteric symptoms (OR 0.070, <jats:italic>P<\/jats:italic> &lt; 0.001), fever (OR 0.115, <jats:italic>P<\/jats:italic> = 0.047), high CRP (OR 0.994, <jats:italic>P<\/jats:italic> = 0.027) and BDCAF level (OR 0.590, <jats:italic>P<\/jats:italic> = 0.010). Uveitis correlates negatively with gastrointestinal involvement in BD patients (OR 3.738, <jats:italic>P<\/jats:italic> = 0.011).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BD could affect the upper gastrointestinal tract independently. Endoscopy should be conducted in all patients in whom a diagnosis of BD is entertained, especially in patients with higher CRP, disease activity and fever. While, BD patients with uveitis correlates negatively with gastrointestinal involvement.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13023-021-02056-0","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T17:02:48Z","timestamp":1634835768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["New insight into the features of Beh\u00e7et\u2019s disease with gastrointestinal ulcer: a cross-sectional observational study"],"prefix":"10.1186","volume":"16","author":[{"given":"Jing-Fen","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Cheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Fang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-2725","authenticated-orcid":false,"given":"Jian-Long","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"2056_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1460491","author":"G Lopalco","year":"2017","unstructured":"Lopalco G, Rigante D, Venerito V, et al. 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