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Eight cases of ENKTL-Breast were selected, with three primary and five secondary lesions, accounting for 3.5% (8\/228) of all breast lymphomas. All patients were female with a median age of 46\u00a0years. Lesions presented as solid breast masses (8\/8, 100%) and were usually located in the upper outer quadrant of the breast (7\/8, 87.5%). B-symptoms were observed in seven (7\/8, 87.5%) cases. Two primary ENKTL-Breast cases showed concomitant diseases (IgA nephropathy and chronic active hepatitis B). Histological and immunohistochemical features of ENKTL-Breast were similar to those of ENKTL at other sites. T-cell receptor rearrangement revealed clonality in all examined primary cases (2\/2, 100%), but only in one secondary case (1\/5, 20%). The disease progressed rapidly in two primary cases and both patients died within 3 and 9\u00a0months. For secondary cases, the disease manifested as a disseminated disease, with a median survival time of 6\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our data suggested that ENKTL-Breast clinically mimics breast cancer to some extent, though B-symptoms might serve as a distinguishing factor. ENKTL-Breast is highly aggressive and patients with this disease exhibit a short survival time. Primary ENKTL-Breast tends to originate from activated cytotoxic T-cells, and immune-related diseases may be involved in its pathogenesis and development.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13023-021-02110-x","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T12:03:12Z","timestamp":1637236992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extranodal natural killer\/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series"],"prefix":"10.1186","volume":"16","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanglan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-7999","authenticated-orcid":false,"given":"Sha","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"2110_CR1","unstructured":"Chan JKC, Quintanilla-Martinez L, Ferry JA. 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