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Affected individuals present with skeletal deformities, bone growth impairment, joint stiffness and frequently mental retardation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The objective of the study was to summarise over 30\u00a0years of observations of the growth dynamics in patients with different types of MPS, performed at the Children\u2019s Memorial Health Institute (CMHI, Warsaw, Poland). A retrospective analysis of anthropometric data collected from 1989 to 2020 was performed for 195 patients with MPS I, MPS II, MPS III, MPS IVA and MPS VI. Mean values for birth body length were statistically significantly greater than in the general population. The mean z-scores for other MPS groups showed that until the 24th month of life, the growth pattern for all patients was similar, and the average z-scores for body height were greater than in reference charts. Afterwards, growth patterns began to differentiate for MPS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The long-term follow up showed that the growth pattern in patients with all types of mucopolysaccharidoses significantly deviates from the general population. Patients with MPS IVA had the most severe growth impairments compared to other patients in the study group. Neuropathic MPS I and II demonstrated severe growth impairments compared to other patients in this study. Patients with MPS III showed the mildest growth impairments compared to other MPS patients and reached the 3rd percentile last.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13023-022-02486-4","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T13:04:55Z","timestamp":1662383095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of growth dynamics in different types of MPS: an attempt to explain the causes"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-5989","authenticated-orcid":false,"given":"Agnieszka","family":"R\u00f3\u017cd\u017cy\u0144ska-\u015awi\u0105tkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zieli\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tylki-Szyma\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"2486_CR1","first-page":"3421","volume-title":"The metabolic and molecular bases of inherited disease","author":"EMJ Neufeld","year":"2001","unstructured":"Neufeld EMJ. 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There was no potential, perceived or real conflict of interest. There were no study sponsors. No honorarium, grant or other form of payment was given to produce the manuscript. All authors fulfil the criteria for authorship, have seen and approved the submission of the manuscript and are willing to take responsibility for the entire manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"339"}}