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Although it is a promising curative option for CNS, many doubts still persist about its long-term efficacy and safety. Furthermore, there is a risk of overlooking several unresolved problems still present in current clinical practice. This letter is a call for action on crucial open issues that remain nowadays an unmet need in the management of CNS patients.<\/jats:p>","DOI":"10.1186\/s13023-024-03108-x","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T04:35:38Z","timestamp":1709786138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Crigler-Najjar syndrome: looking to the future does not make us forget the present"],"prefix":"10.1186","volume":"19","author":[{"given":"Fabiola","family":"Di Dato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"D\u2019Uonno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-234X","authenticated-orcid":false,"given":"Raffaele","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"2","key":"3108_CR1","first-page":"259","volume":"83","author":"JF Crigler Jr","year":"1952","unstructured":"Crigler JF Jr, Najjar VA. 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