{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:55:41Z","timestamp":1776916541254,"version":"3.51.2"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The management of Spinal Muscular Atrophy (SMA) requires a multidisciplinary treatment approach, wherein rehabilitation constitutes an integral element. In this study, we examined the effects of rehabilitation among Chinese SMA patients and assessed the real-world efficacy of rehabilitation interventions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a cross-sectional online survey on SMA patients from June 9, 2023, to June 30, 2023, through the Meier Advocacy &amp; Support Center using data from the Center\u2019s database and electronic questionnaires. The rehabilitation situation of the participants over the past 14 months were investigated. Logistic binary regression was used to analyze the relationship between Pediatric Quality of Life Inventory(PedsQL\u2122) scores and rehabilitation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>A total of 186 questionnaires were finally analyzed. Only 29 patients did not rehabilitated in the past 14 months. A significant correlation between age and type of rehabilitation, as well as between age and duration of rehabilitation. Patients receiving no rehabilitation or solely home-based rehabilitation exhibited a higher median age of 8.4 compared to those undergoing standard rehabilitation or a combination of standard and home-based rehabilitation, with a median age of 4.9 (z-score = -4.49, <jats:italic>p<\/jats:italic>-value\u2009&lt;\u20090.001). In addition, long-term rehabilitation (OR\u2009=\u20090.314, 95%CI\u2009=\u20090.106\u20130.927, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) were negatively correlated with lower PedsQL\u2122 Neuromuscular Module scores, and PedsQL scores in the long-term rehabilitation group were higher than those in the short-term and no-rehabilitation groups (54.2\u2009\u00b1\u200915.1 vs. 45.9\u2009\u00b1\u200914.4 and 42.3\u2009\u00b1\u200914.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), with the most significant difference observed in the physical function section\u00a0(59.0\u2009\u00b1\u200915.8 vs. 46.8\u2009\u00b1\u200915.2 and 45.6\u2009\u00b1\u200915.9, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Mobility and exercise (OR\u2009=\u20090.26, 95%CI\u2009=\u20090.08\u20130.81, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), as well as assistive technology (OR\u2009=\u20090.28, 95%CI\u2009=\u20090.10\u20130.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), were independently associated with a lower score in a negative direction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The study found that long-term rehabilitation was linked to higher PedsQL scores in SMA patients, highlighting the need for standardized rehabilitation programs to enhance function and quality of life.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13023-024-03291-x","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T19:01:41Z","timestamp":1722020501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rehabilitation for spinal muscular atrophy patients in China: a national cross-sectional study"],"prefix":"10.1186","volume":"19","author":[{"given":"Duan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"issue":"1","key":"3291_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-022-00380-8","volume":"8","author":"E Mercuri","year":"2022","unstructured":"Mercuri E, Sumner CJ, Muntoni F, et al. 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