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We focused on disease-related restrictions in various issues of daily life, experienced discrimination, parental family planning, and management of metabolic emergencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a questionnaire-based survey with 108 parents of 119 children with IEM who attended a metabolic outpatient clinic. The children were categorized into 4 cohorts, based on increasing disease severity (cohort 1: IEMs with lowest severity, cohort 4: IEMs with highest severity), and compared by using Tobit regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The severity of the child\u2019s IEM was associated with an increase in the intensity of perceived restrictions from the parents\u2019 perspective for themselves and their children in all aspects of life: in general, in contact with friends, in the pursuit of hobbies, in childcare\/school\/occupation, and due to emotional stress. The highest intensity of restrictions in all cohorts was found for the parents themselves in contact with friends (compared to cohort 1: cohort 2: c. 3.556,<jats:italic>p<\/jats:italic>\u2009=\u20090.002; cohort 3: c. 4.159,<jats:italic>p<\/jats:italic>\u2009=\u20090.003; cohort 4: c. 7.224,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Parents of 8% of children reported that their children were discriminated against because of IEM, with the highest proportion of affected children (43%) in cohort 4. Parental family planning decisions were influenced in 34% of parents, with fear of recurrence being a predominant aspect. Of the parents of children diagnosed with IEMs associated with metabolic emergencies, 68% stated that they felt well or very well prepared for the occurrence of a metabolic emergency, and 100% of parents were able to name the necessary action steps from memory. Nevertheless, 58% stated that they experienced an occurring emergency as rather or very stressful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>From the parents\u2019 perspective, the intensity of restrictions increased with the severity of the child\u2019s IEM. The study shows the high impact of IEM on parents of children with IEM and the daily challenges they face. These findings emphasize the importance of comprehensive support for parents of children with IEM.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13023-024-03315-6","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T16:02:48Z","timestamp":1724688168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of a child\u2019s inborn error of metabolism: the parents\u2019 perspectives on restrictions, discrimination, family planning, and emergency management"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2721-1775","authenticated-orcid":false,"given":"Tanjana","family":"Harings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-0888","authenticated-orcid":false,"given":"Martina P.","family":"Neininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-7384","authenticated-orcid":false,"given":"Simone","family":"Eisenhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-1355","authenticated-orcid":false,"given":"Alena G.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-9455","authenticated-orcid":false,"given":"Wieland","family":"Kiess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-0156","authenticated-orcid":false,"given":"Astrid","family":"Bertsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-6655","authenticated-orcid":false,"given":"Thilo","family":"Bertsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-6512","authenticated-orcid":false,"given":"Skadi","family":"Beblo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"3315_CR1","unstructured":"Gesellschaft f\u00fcr Neonatologie und p\u00e4diatrische Intensivmedizin e.V. 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Approval was granted by the Ethics Committee at the Medical Faculty, Leipzig University, Germany (Date 17 December 2019, No 512\/19-ek). Written informed consent was obtained from all individual parents included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"AB reports grants from UCB Pharma GmbH and honoraria for speaking engagements from Biogen GmbH, Desitin Arzneimittel GmbH, Eisai GmbH, GW Pharma GmbH, Neuraxpharm GmbH, Shire\/Takeda GmbH, UCB Pharma GmbH, and ViroPharma GmbH. SB reports grants from Nutricia metabolics and honoraria for speaking engagements from Sanofi GmbH, Immedica Pharma Germany GmbH and Biomarin Deutschland GmbH. The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"313"}}