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Distribution of genetics was as follows: 13\/57 (22.8%) deletion, 19\/57 (33.3%) uniparental disomy, 2\/57 (3,5%) imprinting defect, 3\/57 (5.3%) non-deletion, 20\/57 (35.1%) diagnosed by analyses of the methylation pattern of chromosome 15q11-13. Mean time interval between COVID-19 infection and post-COVID-19 evaluation was 96.2 days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Course of COVID-19 infection was asymptomatic 8\/82 (9.8%), mild 63\/82 (76.8%), medium 11\/84 (13.4%). The five most frequently experienced symptoms in PWS patients were fever (56.1%); headache (45.1%); cold (42.7%); cough (31.7%) and body aches (21.95%). PWS patients who had COVID-19 infection had significantly lower mean oxygen saturation (SpO2) measured by pulse oximetry (post 94.8% vs. pre 95.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), lower detected lowermost SpO2 (post 86.2 vs. pre 87.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and higher occurrence of hypopnoea (post 13.9 vs. pre 10.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Time in optimal SpO2 (95\u2013100%) decreased significantly (post 54.3% vs. pre 73.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), whereas an increase was observed in time in suboptimal SpO2 (90\u201395%) (post 45.5% vs. 25.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and in time in poor SpO2 (&lt;\u200990%) (post 0.7% vs. pre 0.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.030). Body-Mass-Index (BMI)-SDS for PWS showed no differences between the groups at any time. BMI-SDS-differences showed no influence on differences in SpO2 evaluations. In the genetic subgroup with deletion there was a statistically significant effect on an increased number of OSA (<jats:italic>p<\/jats:italic>\u2009=\u20090.027). The genetic subgroup with uniparental disomy (UPD) was associated with a reduced risk of higher HF (<jats:italic>p<\/jats:italic>\u2009=\u20090.035) and less hypopnea (<jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>PWS patients predominantly experienced only mild to medium symptoms during COVID-19 infection without necessity of hospitalisation. However, on average three months after infection, differences in PSG evaluations were still apparent, manifesting in lower SpO2 and more frequent hypopnea. A long-lasting impairment of the pulmonary system due to the COVID-19 infection might be responsible.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13023-024-03447-9","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T10:07:51Z","timestamp":1734084471000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective longitudinal study on the long-term impact of COVID-19 infection on polysomnographic evaluation in patients with Prader-Willi syndrome"],"prefix":"10.1186","volume":"19","author":[{"given":"Sina","family":"Braun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanze","family":"Laemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-1465","authenticated-orcid":false,"given":"Bettina","family":"Gohlke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"3447_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2174\/1573396315666190716120925","volume":"15","author":"MG Butler","year":"2019","unstructured":"Butler MG, Miller JL, Forster JL. 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