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However, these studies have been primarily conducted in small samples at European centres. We report a retrospective chart review from 1035 consecutive patients (88% female) assessed for EDS\/G-HSD at the GoodHope EDS Clinic at Toronto General Hospital between June 2019 and June 2021. Prior to assessment, all patients completed self-reported mental health screening questions, the Inventory of Depressive and Anxiety Symptoms \u2013 Dysphoria scale, and the Borderline Symptom List-23. The majority of patients reported current or past anxiety or depressive symptoms (53\u201387%), and a substantial minority reported significant mental health concerns, including Posttraumatic Stress Disorder (4.7\u201334.8%), disordered eating (19%), self-harm (3-29.2%), and suicidal behaviour (7.8\u201318.6%). Patients did not differ by diagnostic category on self-report measures of dysphoria or borderline symptoms. Individuals with G-HSD reported higher rates of anxiety and depression in clinical interview than those diagnosed with non-hypermobile EDS, and endorsed a higher rate of having \u201cstruggled with anxiety or depression\u201d on the mental health screening questionnaire than individuals not diagnosed with EDS\/G-HSD. No other differences emerged across diagnostic groups. These findings highlight the need for psychological support for individuals with EDS or G-HSD.<\/jats:p>","DOI":"10.1186\/s13023-025-03550-5","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T21:25:51Z","timestamp":1739568351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rates of mental health concerns among individuals assessed at the GoodHope Ehlers-Danlos Syndrome Clinic"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-4191","authenticated-orcid":false,"given":"P. 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