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Cancer research, adapting to a fast-changing world, is leveraging AI as a promising framework to better understand tumor development. Moreover, current AI methods can help predict more suitable and personalized treatment strategies for specific types of tumors. We explored AI methods applied to Neurofibromatosis Type 1, focusing on glial tumors. Additionally, we have reviewed all publicly available datasets to date. Discussion of future challenges is highly desirable since Neurofibromatosis Type 1 is one of the most common hereditary tumor syndromes and is associated with an increased rate of glial tumors as well as a reduced life expectancy due to malignancy.<\/jats:p>","DOI":"10.1186\/s13023-025-04093-5","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:52:40Z","timestamp":1761832360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Artificial intelligence-based tools for precision diagnosis and treatment of neurofibromatosis type 1 associated peripheral and central glial tumors"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6404-0827","authenticated-orcid":false,"given":"Fabio","family":"Hellmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inka","family":"Ristow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Well","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swanhild","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Anokhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Kuhlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Harder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"issue":"4","key":"4093_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00401-019-02002-2","volume":"139","author":"JS Nix","year":"2019","unstructured":"Nix JS, Blakeley J, Rodriguez FJ. 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