{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:45Z","timestamp":1792788285898,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Beijing Municipal Natural Science Foundation","award":["7242106"],"award-info":[{"award-number":["7242106"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0532204"],"award-info":[{"award-number":["2024ZD0532204"]}]},{"name":"National Key R&D Program of China","award":["2021YFC2501700"],"award-info":[{"award-number":["2021YFC2501700"]}]},{"name":"Independent Research Fund of the State Key Laboratory of Complex, Severe, and Rare Disease","award":["2025-I-PY-007"],"award-info":[{"award-number":["2025-I-PY-007"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-D-006"],"award-info":[{"award-number":["2022-PUMCH-D-006"]}]},{"name":"the National Natural Science Foundation of China","award":["No.82270938"],"award-info":[{"award-number":["No.82270938"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["No.81970757"],"award-info":[{"award-number":["No.81970757"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["No. 82571025"],"award-info":[{"award-number":["No. 82571025"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2023-PT320-10"],"award-info":[{"award-number":["2023-PT320-10"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2025-I2M-XHXX-003"],"award-info":[{"award-number":["2025-I2M-XHXX-003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) secretion. However, TIO lesions located in the neurocranium (NC) and intracranial (IC) structures remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the clinical features of TIO lesions in NC and IC structures and to compare them with those located in the sinuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients diagnosed with TIO who underwent tumor resection at Peking Union Medical College Hospital between January 2016 and December 2023. Patients with lesions in NC and IC structures were defined as the study group, while those with sinus lesions served as the control group. Clinical characteristics, biochemical parameters, and surgical outcomes were systematically analyzed and compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TIO lesions in NC and IC structures were distributed across the skull base, temporal region, sellar region, frontal lobe, and occipital region. Compared with sinus lesions, patients with NC and IC lesions showed comparable clinical and biochemical profiles but exhibited significantly worse outcomes, including higher rates of non-remission and tumor recurrence. These findings suggest increased difficulty in complete tumor resection and disease control in this subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TIO lesions in NC and IC structures are associated with poorer surgical outcomes and higher recurrence rates despite similar baseline characteristics. These results highlight the need for improved localization strategies and tailored management approaches for this challenging subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13023-026-04477-1","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:26:43Z","timestamp":1783427203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics of tumor-induced osteomalacia lesions in the neurocranium and intracranial structures"],"prefix":"10.1186","volume":"21","author":[{"given":"Yushuo","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Jiajue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-9524","authenticated-orcid":false,"given":"Yiyi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7768-5536","authenticated-orcid":false,"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"issue":"9","key":"4477_CR1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1507\/endocrj.EJ15-0275","volume":"62","author":"I Endo","year":"2015","unstructured":"Endo I, Fukumoto S, Ozono K, et al. Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases in Japan: prevalence, biochemical data and treatment. Endocr J. 2015;62(9):811\u20136. https:\/\/doi.org\/10.1507\/endocrj.EJ15-0275.","journal-title":"Endocr J"},{"key":"4477_CR2","doi-asserted-by":"publisher","first-page":"17044","DOI":"10.1038\/nrdp.2017.44","volume":"13","author":"S Minisola","year":"2017","unstructured":"Minisola S, Peacock M, Fukumoto S, et al. Tumour-induced osteomalacia. Nat Rev Dis Primers Jul. 2017;13:3:17044. https:\/\/doi.org\/10.1038\/nrdp.2017.44.","journal-title":"Nat Rev Dis Primers Jul"},{"key":"4477_CR3","doi-asserted-by":"publisher","first-page":"153865","DOI":"10.1016\/j.metabol.2019.01.006","volume":"103s","author":"J Bacchetta","year":"2020","unstructured":"Bacchetta J, Bardet C, Pri\u00e9 D. Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting. Metabolism Feb. 2020;103s:153865. https:\/\/doi.org\/10.1016\/j.metabol.2019.01.006.","journal-title":"Metabolism Feb"},{"issue":"3","key":"4477_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/jbmr.3903","volume":"35","author":"X Li","year":"2020","unstructured":"Li X, Jiang Y, Huo L, et al. Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study. J Bone Min Res Mar. 2020;35(3):469\u201377. https:\/\/doi.org\/10.1002\/jbmr.3903.","journal-title":"J Bone Min Res Mar"},{"issue":"7929","key":"4477_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/s0140-6736(75)92736-1","volume":"16","author":"RJ Walton","year":"1975","unstructured":"Walton RJ, Bijvoet OL. Nomogram for derivation of renal threshold phosphate concentration. Lancet Aug. 1975;16(7929):309\u201310. https:\/\/doi.org\/10.1016\/s0140-6736(75)92736-1.","journal-title":"Lancet Aug"},{"issue":"7","key":"4477_CR6","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00198-016-3543-5","volume":"27","author":"D El-Maouche","year":"2016","unstructured":"El-Maouche D, Dumitrescu CE, Andreopoulou P, et al. Stability and degradation of fibroblast growth factor 23 (FGF23): the effect of time and temperature and assay type. Osteoporos Int Jul. 2016;27(7):2345\u201353. https:\/\/doi.org\/10.1007\/s00198-016-3543-5.","journal-title":"Osteoporos Int Jul"},{"key":"4477_CR7","doi-asserted-by":"publisher","unstructured":"Wu Y, Li X, Xu Z, et al. Data from: clinical characteristics of tumor-induced osteomalacia lesions in the neurocranium and intracranial structures. Figshare. 2024. https:\/\/doi.org\/10.6084\/m9.figshare.27201393.v1.","DOI":"10.6084\/m9.figshare.27201393.v1"},{"issue":"7","key":"4477_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1507\/endocrj.EJ16-0587","volume":"28","author":"J Feng","year":"2017","unstructured":"Feng J, Jiang Y, Wang O, et al. The diagnostic dilemma of tumor induced osteomalacia: a retrospective analysis of 144 cases. Endocr J Jul. 2017;28(7):675\u201383. https:\/\/doi.org\/10.1507\/endocrj.EJ16-0587.","journal-title":"Endocr J Jul"},{"issue":"3","key":"4477_CR9","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/jbmr.4476","volume":"37","author":"X Ni","year":"2022","unstructured":"Ni X, Feng Y, Guan W, et al. Bone Impairment in a Large Cohort of Chinese Patients With Tumor-Induced Osteomalacia Assessed by HR-pQCT and TBS. J Bone Min Res Mar. 2022;37(3):454\u201364. https:\/\/doi.org\/10.1002\/jbmr.4476.","journal-title":"J Bone Min Res Mar"},{"issue":"1","key":"4477_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0194599820975432","volume":"165","author":"Z Zhu","year":"2021","unstructured":"Zhu Z, Xia W, Qi F, et al. Clinical Characteristics and Surgical Outcomes of Sinonasal Lesions Associated With Tumor-Induced Osteomalacia. Otolaryngol Head Neck Surg Jul. 2021;165(1):223\u201331. https:\/\/doi.org\/10.1177\/0194599820975432.","journal-title":"Otolaryngol Head Neck Surg Jul"},{"issue":"3","key":"4477_CR11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00774-016-0756-9","volume":"35","author":"WJ Yu","year":"2017","unstructured":"Yu WJ, He JW, Fu WZ, Wang C, Zhang ZL. Reports of 17 Chinese patients with tumor-induced osteomalacia. J Bone Min Metab May. 2017;35(3):298\u2013307. https:\/\/doi.org\/10.1007\/s00774-016-0756-9.","journal-title":"J Bone Min Metab May"},{"issue":"3","key":"4477_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1530\/ec-18-0552","volume":"8","author":"R Pal","year":"2019","unstructured":"Pal R, Bhadada SK, Singhare A, et al. Tumor-induced osteomalacia: experience from three tertiary care centers in India. Endocr Connect Mar. 2019;8(3):266\u201376. https:\/\/doi.org\/10.1530\/ec-18-0552.","journal-title":"Endocr Connect Mar"},{"issue":"5","key":"4477_CR13","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.anorl.2018.07.001","volume":"135","author":"A Villepelet","year":"2018","unstructured":"Villepelet A, Casiraghi O, Temam S, Moya-Plana A. Ethmoid tumor and oncogenic osteomalacia: Case report and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis Oct. 2018;135(5):365\u20139. https:\/\/doi.org\/10.1016\/j.anorl.2018.07.001.","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis Oct"},{"issue":"2","key":"4477_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.anl.2017.05.006","volume":"45","author":"SV Kane","year":"2018","unstructured":"Kane SV, Kakkar A, Oza N, Sridhar E, Pai PS. Phosphaturic mesenchymal tumor of the nasal cavity and paranasal sinuses: A clinical curiosity presenting a diagnostic challenge. Auris Nasus Larynx Apr. 2018;45(2):377\u201383. https:\/\/doi.org\/10.1016\/j.anl.2017.05.006.","journal-title":"Auris Nasus Larynx Apr"},{"issue":"2","key":"4477_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s12105-015-0668-3","volume":"10","author":"H Qari","year":"2016","unstructured":"Qari H, Hamao-Sakamoto A, Fuselier C, Cheng YS, Kessler H, Wright J. Phosphaturic Mesenchymal Tumor: 2 New Oral Cases and Review of 53 Cases in the Head and Neck. Head Neck Pathol Jun. 2016;10(2):192\u2013200. https:\/\/doi.org\/10.1007\/s12105-015-0668-3.","journal-title":"Head Neck Pathol Jun"},{"issue":"6","key":"4477_CR16","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s00405-019-05341-8","volume":"276","author":"R Kurien","year":"2019","unstructured":"Kurien R, Rupa V, Thomas M. Varied presentation of sinonasal phosphaturic mesenchymal tumour: report of a case series with follow-up. Eur Arch Otorhinolaryngol Jun. 2019;276(6):1677\u201384. https:\/\/doi.org\/10.1007\/s00405-019-05341-8.","journal-title":"Eur Arch Otorhinolaryngol Jun"},{"issue":"11","key":"4477_CR17","doi-asserted-by":"publisher","first-page":"e1365","DOI":"10.1210\/clinem\/dgad252","volume":"18","author":"X Ni","year":"2023","unstructured":"Ni X, Zhang Z, Guan W, et al. Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia. J Clin Endocrinol Metab Oct. 2023;18(11):e1365\u201373. https:\/\/doi.org\/10.1210\/clinem\/dgad252.","journal-title":"J Clin Endocrinol Metab Oct"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13023-026-04477-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-026-04477-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-026-04477-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:52:41Z","timestamp":1791172361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13023-026-04477-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4477"],"URL":"https:\/\/doi.org\/10.1186\/s13023-026-04477-1","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Local Ethics Committee of the Department of Scientific Research at PUMCH(I-23PJ2019).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants before enrollment in the study.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"I certify that neither I nor my co-authors have a conflict of interest as described above that is relevant to the subject matter or materials included in this Work.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"341"}}