{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:39Z","timestamp":1790262159254,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Heidelberg der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Hiccups lasting more than one month (\u201cchronic singultus\u201d) is a rare disease that impairs quality of life. Its low prevalence hampers evidence generation. The new Heidelberg Registry of Chronic Singultus (HeReChroS) aims to gather epidemiological data, assess disease burden, identify care gaps, improve treatment, and contribute to a more precise clinical characterization of the disease. This analysis of real-world data seeks to characterize the current HeReChroS patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The routinely collected data of patients with chronic singultus (ICD 10: G25.3) from October 2022 to March 2025 were retrospectively entered into HeReChroS. Descriptive statistics were calculated on data of the initial visit, including demographics, medical history, and patient-reported outcomes (PROs) such as disease burden and well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 131 patients were included (104 male, 27 female). Common symptoms alongside hiccups included fatigue (90%), sleep disorders (80%), and concentration difficulties (70%). Comorbidity frequency was high (median 3, IQR 2, range 0\u20139, mode 2 comorbid organ systems), with gastrointestinal (75%), vascular (52%), and pulmonary (28%) conditions most common. Well-being was markedly reduced (mean 35.3, SD 22, range 0\u201390, on a 0\u2013100 scale). Screening questionnaires suggested that 42% of patients were depressed, and 15% of patients reported suicidal thoughts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      HeReChroS offers a large dataset of patients with chronic singultus, enabling in-depth analysis of this rare disease. Quality of life is markedly impaired, and management remains challenging. Expanding the registry across countries and languages would enhance the statistical power and generalizability. German Clinical Trials Registry (Number: DRKS00033956, 25 March 2024, URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.drks.de\/DRKS00033956\" ext-link-type=\"uri\">https:\/\/www.drks.de\/DRKS00033956<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13023-026-04571-4","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:05:47Z","timestamp":1788800747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real world data from the Heidelberg Registry of Chronic Singultus (HeReChroS)"],"prefix":"10.1186","volume":"21","author":[{"given":"Claudia","family":"Busch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3173-3214","authenticated-orcid":false,"given":"Marco Richard","family":"Zugaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Zental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ke\u00dfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"9","key":"4571_CR1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/apt.13374","volume":"42","author":"M Steger","year":"2015","unstructured":"Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther. 2015;42(9):1037\u201350.","journal-title":"Aliment Pharmacol Ther"},{"key":"4571_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ijscr.2020.12.023","volume":"78","author":"K Tariq","year":"2021","unstructured":"Tariq K, Das JM, Monaghan S, Miserocchi A, McEvoy A. A case report of Vagus nerve stimulation for intractable hiccups. Int J Surg Case Rep. 2021;78:219\u201322.","journal-title":"Int J Surg Case Rep"},{"issue":"1","key":"4571_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13023-025-03619-1","volume":"20","author":"MR Zugaj","year":"2025","unstructured":"Zugaj MR, Busch C, Zuger A, Kessler J. Experience of illness with chronic singultus: a qualitative interview study. 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G\u00f6ttingen: Hogrefe AG; 2021. pp. 159\u201371."}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13023-026-04571-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-026-04571-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13023-026-04571-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:08:52Z","timestamp":1790258932000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13023-026-04571-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4571"],"URL":"https:\/\/doi.org\/10.1186\/s13023-026-04571-4","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"5 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"HeReChroS was reviewed by the Ethics Committee of the Medical Faculty of Heidelberg (S-014\/2024) and registered with the German Clinical Trials Registry (DRKS00033956 -\n                      \n                      ). The registry was enrolled in accordance with national law and the Declaration of Helsinki of 1975 (in the current, revised version). Informed consent to participate and for publication was obtained from all patients we could contact.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"332"}}